Patents by Inventor Darryl C. Zeldin

Darryl C. Zeldin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATING NEPHROPATHY
    Publication number: 20180185309
    Abstract: Provided are compositions and methods for improving podocyte and kidney function and glucose homeostasis in diabetic and pre-diabetic states.
    Type: Application
    Filed: June 2, 2016
    Publication date: July 5, 2018
    Applicants: The Regents of the University of California, United States of America, as Represented by Secretary of Health and Human Services
    Inventors: Bruce D. HAMMOCK, Fawaz G. HAJ, Ahmed BETTAIEB, Darryl C. Zeldin
  • INHIBITORS OF EPOXIDE HYDROLASES FOR THE TREATMENT OF HYPERTENSION
    Publication number: 20110245331
    Abstract: The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 is each independently C1-C20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.
    Type: Application
    Filed: May 20, 2011
    Publication date: October 6, 2011
    Applicants: The Regents of the University of California, GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUM
    Inventors: Deanna L. Kroetz, Darryl C. Zeldin, Bruce D. Hammock, Christophe Morisseau
  • Compositions and methods for diagnostics and therapeutics for hydrocephalus
    Patent number: 8008463
    Abstract: The present disclosure relates to RFX4_v3 protein and nucleic acids encoding the RFX4_v3 protein. The present disclosure provides non-human transgenic animals with altered RFX4_v3 genes, and provides assays for the detection of RFX4_v3 and RFX4_v3 polymorphisms associated with disease states. The present disclosure additionally provides methods of determining a subjects' risk of developing congenital hydrocephalus, and treating or inhibiting its development.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: August 30, 2011
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Perry J. Blackshear, Deborah J. Stumpo, Darryl C. Zeldin, Joan P. Graves
  • Inhibitors of epoxide hydrolases for the treatment of hypertension
    Publication number: 20040092487
    Abstract: The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension.
    Type: Application
    Filed: October 27, 2003
    Publication date: May 13, 2004
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE GOVERNMENT OF THE U.S., as represented by the Sec. of the Dept. of Health and Human Services
    Inventors: Deanna L. Kroetz, Darryl C. Zeldin, Bruce D. Hammock, Christophe Morisseau
  • Inhibitors of epoxide hydrolases for the treatment of hypertension
    Patent number: 6693130
    Abstract: The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by wherein R is alkyl or aryl, the compound is trans-across the epoxide ring, OX is a carbonyl (═O) or hydroxy group (OH) and R′ is a H, alkyl or aryl group. The invention further provides methods of identifying patients at increased risk for hypertension, comprising assaying for epoxide hydrolase activity in a urine sample from the patient. In particular, the assays comprise determining the amount of dihydroxyeicosatrienoic acids (DHETs), determining the amount of epoxyeicosatrienoic acids (EETs) in said sample, or determining the amount of both DHETs and EETs in said sample.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: February 17, 2004
    Assignee: Regents of the University of California
    Inventors: Deanna L. Kroetz, Darryl C. Zeldin, Bruce D. Hammock, Christophe Morisseau
  • Inhibitors of epoxide hydrolases for the treatment of hypertension
    Publication number: 20030119900
    Abstract: The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension.
    Type: Application
    Filed: December 23, 2002
    Publication date: June 26, 2003
    Applicant: The Regents of the University of California
    Inventors: Deanna L. Kroetz, Darryl C. Zeldin, Bruce D. Hammock, Christophe Morisseau
  • Inhibitors of epoxide hydrolases for the treatment of hypertension
    Patent number: 6531506
    Abstract: The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula I wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 is each independently C1-C20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: March 11, 2003
    Assignee: Regents of the University of California
    Inventors: Deanna L. Kroetz, Darryl C. Zeldin, Bruce D. Hammock, Christophe Morisseau