Patents by Inventor DARRYL CLEARY

DARRYL CLEARY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-distillative process for manufacturing high purity amphetamines
    Patent number: 12534428
    Abstract: The invention provides a non-distillative process for manufacturing amphetamine and substituted amphetamines, comprising obtaining a highly pure phosphoramidate compound, converting the highly pure phosphoramidate compound to an amphetamine sulfate compound, concentrating the amphetamine sulfate compound in isopropanol, and then salting out the amphetamine compound directly to obtain an amphetamine salt, the amphetamine salt selected from amphetamine saccharate, amphetamine sulfate, amphetamine aspartate, alkyl-amphetamine saccharate, alkyl-amphetamine sulfate, alkyl-amphetamine aspartate, aryl-amphetamine saccharate, aryl-amphetamine sulfate, aryl-amphetamine aspartate, and mixtures thereof.
    Type: Grant
    Filed: February 22, 2023
    Date of Patent: January 27, 2026
    Assignee: Pharmapotheca A, Inc.
    Inventors: Harold Meckler, Darryl Cleary, Karl Popp, Heidi Schlager, Mozhgan Navidi, Joshua Malone
  • Process for Making Lisdexamfetamine Dimesylate
    Publication number: 20250206698
    Abstract: The invention relates to a novel process for making lisdexamfetamine dimesylate and related derivatives by the novel amino acid activation and amphetamine acylation in the presence of water or alcohols. A second invention relates to the novel process for making lisdexamfetamine dimesylate from racemic amphetamine compounds where the single isomer product is isolated without a chemical or enzymatic resolution.
    Type: Application
    Filed: December 23, 2024
    Publication date: June 26, 2025
    Inventors: HAROLD MECKLER, DARRYL CLEARY, MARCUS BRACKEEN, SREENIVASULU KODURU, NILAMBER MATE, KARL POPP
  • Non-distillative Process for Manufacturing High Purity Amphetamines
    Publication number: 20240286993
    Abstract: The invention provides a non-distillative process for manufacturing amphetamine and substituted amphetamines, comprising obtaining a highly pure phosphoramidate compound, converting the highly pure phosphoramidate compound to an amphetamine sulfate compound, concentrating the amphetamine sulfate compound in isopropanol, and then salting out the amphetamine compound directly to obtain an amphetamine salt, the amphetamine salt selected from amphetamine saccharate, amphetamine sulfate, amphetamine aspartate, alkyl-amphetamine saccharate, alkyl-amphetamine sulfate, alkyl-amphetamine aspartate, aryl-amphetamine saccharate, aryl-amphetamine sulfate, aryl-amphetamine aspartate, and mixtures thereof.
    Type: Application
    Filed: February 22, 2023
    Publication date: August 29, 2024
    Inventors: Harold MECKLER, Darryl CLEARY, Karl POPP, Heidi SCHLAGER, Mozhgan NAVIDI, Joshua MALONE
  • Process for making levoamphetamine
    Patent number: 12006275
    Abstract: This is invention is related to processes for synthesis of levoamphetamine derivatives and novel intermediates thereby, and processes for using the same.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: June 11, 2024
    Assignee: Pharmapotheca A, Inc.
    Inventors: Harold Meckler, Praveen Suryadevara, Marcus Brackeen, Darryl Cleary
  • Process for Making Levoamphetamine
    Publication number: 20220162153
    Abstract: This is invention is related to processes for synthesis of levoamphetamine derivatives and novel intermediates thereby, and processes for using the same.
    Type: Application
    Filed: March 2, 2020
    Publication date: May 26, 2022
    Inventors: HAROLD MECKLER, PRAVEEN SURYADEVARA, MARCUS BRACKEEN, DARRYL CLEARY