Patents by Inventor Darryl J. C. Pappin

Darryl J. C. Pappin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Labeling reagents for analyte determination and methods and compounds used in making the same
    Patent number: 8975404
    Abstract: Provided herein are labeling reagents for analyte determination in a sample, and methods of manufacturing the labeling reagents. By way of non-limiting example, analytes may include one or more of peptides, proteins, nucleic acid molecules, carbohydrates, lipids, steroids and/or small molecules. Also provided are labeled analytes themselves after one or more labeling reagents binds to an analyte. Analytes may be labeled for determination of the analyte by mass analysis, such as by mass spectrometry. Further provided are compounds that may be used in making the labeling reagents and labeled analytes, such as reporter group compounds. Also provided are kits that include at least one labeling reagent, and may further include or more other reagents, containers, enzymes, buffers, a labeled analyte (e.g., as a standard) and/or instructions. Further examples are also possible.
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: March 10, 2015
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Sasi K. Pillai, Subhakar Dey, Subhasish Purkayastha, Darryl J. C. Pappin
  • Kits pertaining to analyte determination
    Patent number: 8679773
    Abstract: This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: March 25, 2014
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Darryl J. C. Pappin, Michael Bartlett-Jones
  • Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
    Patent number: 8569304
    Abstract: In some embodiments, this invention pertains to active esters of N-substituted piperazine acetic acid, including isotopically enriched versions thereof. In some embodiments, this invention pertains to methods for the preparation of active esters of N-substituted piperazine acetic acid, including isotopically enriched versions thereof.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: October 29, 2013
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Subhakar Dey, Darryl J. C. Pappin, Subhasish Purkayastha, Sasi Pillai, James M. Coull
  • Mass tags for quantitative analyses
    Patent number: 8501498
    Abstract: This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: August 6, 2013
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Xiongwei Yan, Pau-Miau Yuan, Sylvia W. Yuen, Kuo-Liang Hsi, Joe Y. Lam, Krishna G. Upadhya, Subhakar Dey, Darryl J. C. Pappin, Sasi Pillai, Helena Huang, Subhasish Purkayastha
  • Isobarically labeled analytes and fragment ions derived therefrom
    Patent number: 8273706
    Abstract: This invention pertains to isobarically labeled analytes and fragment ions thereof.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: September 25, 2012
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Darryl J. C. Pappin, Subhasish Purkayastha, James M. Coull
  • ANALYSIS OF MASS SPECTRAL DATA IN THE QUIET ZONES
    Publication number: 20110236982
    Abstract: Embodiments of this invention relate to the analysis of mass spectral data in the quiet zones.
    Type: Application
    Filed: December 14, 2010
    Publication date: September 29, 2011
    Applicant: DH Technologies Development PTE, LTD.
    Inventor: Darryl J.C. Pappin
  • Compositions and Kits Pertaining to Analyte Determination
    Publication number: 20110217720
    Abstract: This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
    Type: Application
    Filed: March 14, 2011
    Publication date: September 8, 2011
    Inventors: Darryl J.C. Pappin, Michael Bartlet-Jones
  • Method and apparatus for de-convoluting a convoluted spectrum
    Patent number: 7952066
    Abstract: Embodiments of the present invention relate to methods, systems, and apparatus suitable for performing a survey scan of one or more analytes or labeled fragments of analytes to obtain a convoluted spectrum and to de-convolute the convoluted spectrum using, for example, a mass spectrometer and associated processing system.
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: May 31, 2011
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Darryl J.C. Pappin, Nikita Khainovski, Darryl S. Spencer
  • Sets and compositions pertaining to analyte determination
    Patent number: 7947513
    Abstract: This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
    Type: Grant
    Filed: February 12, 2007
    Date of Patent: May 24, 2011
    Assignee: DH Technologies Ptd. Ltd.
    Inventors: Darryl J. C. Pappin, Michael Bartlett-Jones
  • Isotopically enriched N-substituted piperazines and methods for the preparation thereof
    Patent number: 7932388
    Abstract: In some embodiments, this invention pertains to isotopically enriched N-substituted piperazines. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazines.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: April 26, 2011
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Darryl J. C. Pappin, Sasi Pillai, James M. Coull
  • Methods compositions and kits pertaining to analyte determination
    Patent number: 7910059
    Abstract: This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
    Type: Grant
    Filed: January 7, 2008
    Date of Patent: March 22, 2011
    Assignee: DH Technologies Pte. Ltd.
    Inventors: Darryl J. C. Pappin, Michael Bartlet-Jones
  • Kits Pertaining to Analyte Determination
    Publication number: 20110045516
    Abstract: This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
    Type: Application
    Filed: January 16, 2007
    Publication date: February 24, 2011
    Applicant: Applera Corporation
    Inventors: Darryl J.C. Pappin, Michael Bartlet-Jones
  • MASS TAGS FOR QUANTITATIVE ANALYSES
    Publication number: 20100311175
    Abstract: This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
    Type: Application
    Filed: November 13, 2009
    Publication date: December 9, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Xiongwei YAN, Pau Miau Yuan, Sylvia W. Yuen, Kuo-Liang Hsi, Joe Y. Lam, Krishna G. Upadhya, Subhakar Dey, Darryl J.C. Pappin, Sasi Pillai, Helena Huang, Subhasish Purkayastha
  • Isobaric labels for mass spectrometric analysis of peptides and method thereof
    Patent number: 7799576
    Abstract: This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: September 21, 2010
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Darryl J. C. Pappin, Michael Bartlet-Jones
  • ISOBARICALLY LABELED ANALYTES AND FRAGMENT IONS DERIVED THEREFROM
    Publication number: 20100129842
    Abstract: This invention pertains to isobarically labeled analytes and fragment ions thereof.
    Type: Application
    Filed: September 16, 2009
    Publication date: May 27, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Darryl J.C. PAPPIN, Subhasish Purkayastha, James M. Coull
  • Methods and Mixtures Pertaining to Analyte Determination Using Electrophilic Labeling Reagents
    Publication number: 20100112708
    Abstract: This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
    Type: Application
    Filed: October 20, 2009
    Publication date: May 6, 2010
    Applicants: LIFE TECHNOLOGIES CORPORATION, Applied Biosystems, LLC
    Inventors: Darryl J.C. Pappin, Michael Bartlet-Jones
  • Active Esters of N-Substituted Piperazine Acetic Acids, Including Isotopically Enriched Versions Thereof
    Publication number: 20090227791
    Abstract: In some embodiments, this invention pertains to active esters of N-substituted piperazine acetic acid, including isotopically enriched versions thereof. In some embodiments, this invention pertains to methods for the preparation of active esters of N-substituted piperazine acetic acid, including isotopically enriched versions thereof.
    Type: Application
    Filed: March 5, 2009
    Publication date: September 10, 2009
    Inventors: Subhakar Dey, Darryl J.C. Pappin, Subhasish Purkayastha, Sasi Pillai, James M. Coull
  • Isotopically Enriched N-Substituted Piperazine Acetic Acids And Methods For The Preparation Thereof
    Publication number: 20090176984
    Abstract: In some embodiments, this invention pertains to isotopically enriched N-substituted piperazine acetic acids. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazine acetic acids.
    Type: Application
    Filed: February 29, 2008
    Publication date: July 9, 2009
    Inventors: Subhakar Dey, Darryl J.C. Pappin, Subhasish Purkayastha, Sasi Pillai, James M. Coull
  • Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
    Patent number: 7355045
    Abstract: In some embodiments, this invention pertains to isotopically enriched N-substituted piperazine acetic acids. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazine acetic acids.
    Type: Grant
    Filed: January 5, 2004
    Date of Patent: April 8, 2008
    Assignee: Applera Corporation
    Inventors: Subhakar Dey, Darryl J. C. Pappin, Subhasish Purkayastha, Sasi Pillai, James M. Coull
  • Method and apparatus for de-convoluting a convoluted spectrum
    Patent number: 7309858
    Abstract: Embodiments of the present invention relate to methods, systems, and apparatus suitable for performing a survey scan of one or more analytes or labeled fragments of analytes to obtain a convoluted spectrum and to de-convolute the convoluted spectrum using, for example, a mass spectrometer and associated processing system.
    Type: Grant
    Filed: July 17, 2006
    Date of Patent: December 18, 2007
    Assignee: Applera Corporation
    Inventors: Darryl J. C. Pappin, Nikita Khainovski, Darryl D. Spencer