Patents by Inventor Darryl M. See

Darryl M. See has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inducing a systemic immune response to an antigen
    Publication number: 20040258746
    Abstract: A method is provided for inducing a systemic immune response to an antigen. The method comprises providing a liposomal preparation comprising lyophilized liposomes containing at least one antigen. The liposomes have at least two sizes, before lyophilization, selected from small liposomes having a size, before lyophilization, of from about 20 nm to about 1 micron, medium liposomes having a size, before lyophilization, of from about 1 micron to about 3 microns, and large liposomes having a size, before lyophilization, of from about 3 microns to about 20 microns. An effective amount of the liposomal preparation is administered to a mammal, whereby sufficient antigen containing liposomes are absorbed in the Peyer's patches of the gut of the mammal and are taken up by macrophages in the Peyer's patches to stimulate a systemic immune response.
    Type: Application
    Filed: April 8, 2004
    Publication date: December 23, 2004
    Applicant: Oral Vaccine Technologies, Inc.
    Inventors: Jackie R. See, Darryl M. See
  • Method for inducing a systemic immune response to an HIV antigen
    Publication number: 20020142030
    Abstract: A method is provided for inducing a systemic immune response to an antigen selected from inactivated HIV I and HIV II antigens in a mammal. The method comprises orally administering lyophilized multilaminar liposomes containing the antigen. The liposomes have a size of from 20 nm to 20 microns. The antigen-containing liposomes are absorbed in the Peyer's patches of the gut. Sufficient antigen-containing liposomes are taken up by macrophages in the Peyer's patches to induce a systemic immune response to the antigen.
    Type: Application
    Filed: January 25, 2002
    Publication date: October 3, 2002
    Applicant: Oral Vaccine Technologies, Inc.
    Inventors: Jackie R. See, Darryl M. See
  • Method for inducing a systemic immune response to an antigen
    Publication number: 20020136762
    Abstract: A method is provided for inducing a systemic immune response to an antigen. The method comprises providing a liposomal preparation comprising lyophilized liposomes containing at least one antigen. The liposomes have at least two sizes, before lyophilization, selected from small liposomes having a size, before lyophilization, of from about 20 nm to about 1 micron, medium liposomes having a size, before lyophilization, of from about 1 micron to about 3 microns, and large liposomes having a size, before lyophilization, of from about 3 microns to about 20 microns. An effective amount of the liposomal preparation is administered to a mammal, whereby sufficient antigen containing liposomes are absorbed in the Peyer's patches of the gut of the mammal and are taken up by macrophages in the Peyer's patches to stimulate a systemic immune response.
    Type: Application
    Filed: January 25, 2002
    Publication date: September 26, 2002
    Inventors: Jackie R. See, Darryl M. See
  • Method for inducing a systemic immune response to an antigen
    Publication number: 20010024651
    Abstract: A method is provided for inducing a systemic immune response to an antigen selected from inactivated HIV I and HIV II antigens in a mammal. The method comprises orally administering lyophilized multilaminar liposomes containing the antigen. The liposomes have a size of from 20 nm to 20 microns. The antigen-containing liposomes are absorbed in the Peyer's patches of the gut. Sufficient antigen-containing liposomes are taken up by macrophages in the Peyer's patches to induce a systemic immune response to the antigen.
    Type: Application
    Filed: March 26, 2001
    Publication date: September 27, 2001
    Inventors: Jackie R. See, Darryl M. See
  • Method for inducing a systemic immune response to an HIV antigen
    Patent number: 6207185
    Abstract: A method is provided for inducing a systemic immune response to an antigen selected from inactivated HIV I and HIV II antigens in a mammal. The method comprises orally administering lyophilized multilaminar liposomes containing the antigen. The liposomes have a size of from 20 nm to 20 microns. The antigen-containing liposomes are absorbed in the Peyer's patches of the gut. Sufficient antigen-containing liposomes are taken up by macrophages in the Peyer's patches to induce a systemic immune response to the antigen.
    Type: Grant
    Filed: October 10, 1997
    Date of Patent: March 27, 2001
    Assignee: Bio-Sphere Technology
    Inventors: Jackie R. See, Darryl M. See
  • Method for inducing a systemic immune response to a hepatitis antigen
    Patent number: 6117449
    Abstract: A method is provided for inducing a systemic immune response to an antigen selected from hepatitis B and hepatitis C antigens in a mammal. The method comprises orally administering lyophilized multilamellar liposomes containing the antigen. The liposomes have a size of from 20 nm to 20 microns. The antigen-containing liposomes are absorbed in the Peyer's patches of the gut. Sufficient antigen-containing liposomes are taken up by macrophages in the Peyer's patches to induce a systemic immune response to the antigen.
    Type: Grant
    Filed: January 14, 1998
    Date of Patent: September 12, 2000
    Assignee: Bio-Sphere Technology, Inc.
    Inventors: Jackie R. See, Darryl M. See
  • Method for inducing a systemic immune response to an antigen
    Patent number: 6015576
    Abstract: A method is provided for inducing a systemic immune response to an antigen in a mammal. The method comprises orally administering lyophilized multilamellar liposomes containing the antigen. The liposomes have a size of from 20 nm to 20 microns. The antigen-containing liposomes are absorbed in the Peyer's patches of the gut. Sufficient antigen-containing liposomes are taken up by macrophages in the Peyer's patches to induce a systemic immune response to the antigen.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: January 18, 2000
    Assignee: Bio-Sphere Technology, Inc.
    Inventors: Jackie R. See, Darryl M. See