Abstract: The present invention teaches novel pharmaceutical compositions, dosing and treatment regimens for ENT infections, such as rhinosinusitis. The compositions can also be used by those without active rhinosinusitis to reduce and remove harmful germ dwelling and colonizing inside the nasal cavity and its surrounding passages, and prevent rhinosinusitis and other infections from happening. In one of the embodiment of the invention, the composition comprises of hydrogen peroxide, zinc chloride and sodium benzoate.