Patents by Inventor Daruka Mahadevan

Daruka Mahadevan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF NUCLEOPHOSMIN (NPM) AND METHODS FOR INDUCING APOPTOSIS
    Publication number: 20080221146
    Abstract: Nucleophosmin inhibitors are disclosed which inhibit the multimerization of nucleophosmin and the biological activity of nucleophosmin, such as the ability of nucleophosmin to inhibit apoptosis and inhibit cellular differentiation. These small molecule inhibitors are useful for treating diseases and disorders, such as cancer associated with dysregulated nucleophosmin expression. Methods for identifying small molecule inhibitors of nucleophosmin involving multimerization sites for nucleophosmin are also disclosed.
    Type: Application
    Filed: February 28, 2008
    Publication date: September 11, 2008
    Applicant: ARIZONA BOARD OF REG. ON BEHALF ON THE UNIV. OF AZ
    Inventors: Daruka Mahadevan, Wenquing Qi, Bogdan Olenyuk
  • Protein Kinase Inhibitors
    Publication number: 20080051414
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Application
    Filed: March 1, 2007
    Publication date: February 28, 2008
    Applicants: Arizona Board of Regents on Behalf of The University of Arizona, SuperGen,Inc
    Inventors: Laurence Hurley, Daruka Mahadevan, Haiyong Han, David Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Ruben Munoz, Steven Warner, Kimiko Della Croce, Daniel Von Hoff, Cory Grand, James Welsh
  • Substituted tricyclic compounds as protein kinase inhibitors
    Patent number: 7335662
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: February 26, 2008
    Assignees: Arizona Board of Regents on Behalf of the University of Arizona, Montigen Pharmaceuticals, Inc.
    Inventors: Laurence H. Hurley, Daruka Mahadevan, David J. Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Steven L. Warner
  • Substituted tricyclic compounds as protein kinase inhibitors
    Patent number: 7326712
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: February 5, 2008
    Assignees: Arizona Board of Regents on behalf of The University of Arizona, Supergen, Inc.
    Inventors: Laurence H. Hurley, Daruka Mahadevan, David J. Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Steven L. Warner
  • Substituted tricyclic compound as protein kinase inhibitors
    Patent number: 7326713
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: February 5, 2008
    Assignees: Arizona board of Regents on Behalf of the University of Arizona, Montigen Pharmaceuticals, Inc.
    Inventors: Laurence H. Hurley, Daruka Mahadevan, David J. Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Steven L. Warner
  • Substituted tricyclic compounds as protein kinase inhibitors
    Patent number: 7312226
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: December 25, 2007
    Assignees: Arizona Board of Regents on Behalf of The University of Arizona, Montigen Pharmaceuticals, Inc.
    Inventors: Laurence H. Hurley, Daruka Mahadevan, David J. Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Steven L. Warner
  • Composition and method for cancer treatment
    Publication number: 20060088521
    Abstract: Anti-CEACAM6 antibodies and antibody fragments, nucleic acids encoding them, methods of their manufacture, and methods to treat cancer using these compounds are provided.
    Type: Application
    Filed: March 10, 2005
    Publication date: April 27, 2006
    Applicant: University of Arizona
    Inventor: Daruka Mahadevan
  • Protein kinase inhibitors
    Publication number: 20050277658
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Application
    Filed: March 29, 2005
    Publication date: December 15, 2005
    Applicants: Arizona Board of Regents on behalf of The University of Arizona, Montigen Pharmaceuticals, Inc.
    Inventors: Laurence Hurley, Daruka Mahadevan, Haiyong Han, David Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Ruben Munoz, Steven Warner, Kimiko Della Croce, Daniel Von Hoff, Cory Grand
  • Protein kinase inhibitors
    Publication number: 20050239794
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Application
    Filed: March 29, 2005
    Publication date: October 27, 2005
    Applicants: Arizona Board of regents on behalf of the University of Arizona, Montigen Pharmaceuticals, Inc.
    Inventors: Laurence Hurley, Daruka Mahadevan, Haiyong Han, David Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Ruben Munoz, Steven Warner, Kimiko Della Croce, Daniel Von Hoff, Cory Grand
  • Protein kinase inhibitors
    Publication number: 20050239793
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Application
    Filed: March 29, 2005
    Publication date: October 27, 2005
    Applicants: Arizona Board of Regents on behalf of The University of Arizona, Montigen Pharmaceuticals, Inc.
    Inventors: Laurence Hurley, Daruka Mahadevan, Haiyong Han, David Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Ruben Munoz, Steven Warner, Kimiko Della Croce, Daniel Von Hoff, Cory Grand
  • Protein kinase inhibitors
    Publication number: 20050227992
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Application
    Filed: October 14, 2004
    Publication date: October 13, 2005
    Applicants: Arizona Board of Regents on behalf of The University of Arizona, Montigen Pharmaceuticals, Inc.
    Inventors: Laurence Hurley, Daruka Mahadevan, Haiyong Han, David Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Ruben Munoz, Steven Warner, Kimiko Della Croce, Daniel Von Hoff, Cory Grand