Patents by Inventor Darwin R. Reed

Darwin R. Reed has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleotide sequences encoding enzymes in biosynthesis of dihydroartemisinic acid
    Patent number: 8207402
    Abstract: Isolated nucleic acid molecules cloned from Artemisia annua encode artemisinic aldehyde double bond reductase and artemisinic/dihydroartemisinic aldehyde dehydrogenase. Artemisinic aldehyde double bond reductase enzymatically reduces artemisinic aldehyde to dihydroartemisinic aldehyde. Artemisinic/dihydroartemisinic aldehyde dehydrogenase enzymatically oxidizes dihydroartemisinic aldehyde to dihydroartemisinic acid and artemisinic aldehyde to artemisinic acid. The nucleic acid molecules, and the enzymes encoded thereby, may be used in processes to produce dihydroartemsinic aldehyde, dihydroartemisinic acid or artemisinic acid in a host cell. Dihydroartemisinic acid is a late precursor to the a antimalarial compound artemisinin.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: June 26, 2012
    Assignee: National Research Council of Canada
    Inventors: Keat (Thomas) H. Teoh, Darwin R. Reed, Devin R. Polichuk, Patrick S. Covello