Patents by Inventor Darwin YE

Darwin YE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced immunotherapy of cancer using targeted transcriptional modulators
    Patent number: 11285149
    Abstract: The present invention relates to a combination of a signal transducer and activator of transcription 3 (STAT3) activity inhibitor; and an immune checkpoint inhibitor for use in treating or preventing the hyperproliferative disorder in a subject. Preferably, the STA3 activity inhibitor is pyrimethamine or atovaquone, and the immune checkpoint inhibitor is an anti-PD1 antibody. Preferably, the hyperproliferative disorder is a glioma or a glioblastoma.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: March 29, 2022
    Assignee: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: David Frank, Darwin Ye
  • ENHANCED IMMUNOTHERAPY OF CANCER USING TARGETED TRANSCRIPTIONAL MODULATORS
    Publication number: 20200230135
    Abstract: The present invention relates to a combination of a signal transducer and activator of transcription 3 (STAT3) activity inhibitor; and an immune checkpoint inhibitor for use in treating or preventing the hyperproliferative disorder in a subject. Preferably, the STA3 activity inhibitor is pyrimethamine or atovaquone, and the immune checkpoint inhibitor is an anti-PD1 antibody. Preferably, the hyperproliferative disorder is a glioma or a glioblastoma.
    Type: Application
    Filed: July 27, 2018
    Publication date: July 23, 2020
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: David FRANK, Darwin YE