Patents by Inventor Daryl E. Hartter

Daryl E. Hartter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reagents and methods for the quantification of amitriptyline or nortriptyline in biological fluids
    Patent number: 5614419
    Abstract: Immunoassay methods and reagents for the specific quantification of amitriptyline or nortriptyline in a test sample are disclosed employing antibodies prepared with amitriptyline or nortriptyline derivatives of the Formula III: ##STR1## wherein for amitriptyline, R is CH.sub.3, and for nortriptyline, R is H. The present invention also describes the synthesis of unique fluorescein tracers of the structure of Formula IV and Formula V: ##STR2## wherein for a specific amitriptyline immunoassay, W.sub.1 is a heteroatom linked to the aromatic ring at the 2 or 3 position, and for a specific nortriptyline immunoassay, W.sub.2 is two heteroatoms linked together and attached to the aromatic ring at the 2 or 3 position, and wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: March 25, 1997
    Assignee: Abbott Laboratories
    Inventors: Maciej Adamczyk, Jeffrey R. Fishpaugh, Donald Johnson, Daryl E. Hartter
  • Determination of tricyclic antidepressant drugs in the presence of interfering substances
    Patent number: 5413911
    Abstract: Method and reagents for determining a compound of interest present in a test sample also containing one or more interfering compounds having substantially similar chemical structures, and otherwise analytically indistinguishable from each other, employing a pretreatment reagent capable of selectively modifying the chemical structure of one of the compounds without significantly modifying or altering the chemical structure of the other one of the compounds.
    Type: Grant
    Filed: December 14, 1990
    Date of Patent: May 9, 1995
    Assignee: Abbott Laboratories
    Inventors: Maciej Adamczyk, Jeffrey R. Fishpaugh, Charles A. Harrington, Daryl E. Hartter, Robert E. Hruska
  • Reagents and methods for the quantification of amitriptyline or nortriptyline in biological fluids
    Patent number: 5407835
    Abstract: Immunoassay methods and reagents for the specific quantification of amitriptyline or nortriptyline in a test sample are disclosed employing antibodies prepared with amitriptyline or nortriptyline derivatives of the Formula III: ##STR1## wherein for amitriptyline, R is CH.sub.3, and for nortriptyline, R is H. The present invention also describes the synthesis of unique fluorescein tracers of the structure of Formula IV and Formula V: ##STR2## wherein for a specific amitriptyline immunoassay, W.sub.1 is a heteroatom linked to the aromatic ring at the 2 or 3 position, and for a specific nortriptyline immunoassay, W.sub.2 is two heteroatoms linked together and attached to the aromatic ring at the 2 or 3 position, and wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative.
    Type: Grant
    Filed: July 24, 1992
    Date of Patent: April 18, 1995
    Assignee: Abbott Laboratories
    Inventors: Maciej Adamczyk, Jeffrey R. Fishpaugh, Donald Johnson, Daryl E. Hartter