Patents by Inventor Daryl J. Kelly

Daryl J. Kelly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRUNCATED RECOMBINANT MAJOR OUTER MEMBRANE PROTEIN ANTIGEN (R56) OF ORIENTIA TSUTSUGAMUSHI STRAINS KARP, KATO and GILLIAM AND ITS USE IN ANTIBODY BASED DETECTION ASSAYS AND VACCINES
    Publication number: 20110045011
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulation sand production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Application
    Filed: October 29, 2010
    Publication date: February 24, 2011
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Truncated recombinant major outer membrane protein antigen (R56) of orientia tsutsugamushi strains karp, kato and gilliam and its use in antibody based detection assays and vaccines
    Patent number: 7846675
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulation sand production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: December 7, 2010
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Truncated recombinant major outer membrane protein antigen (R56) of strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines
    Patent number: 7638130
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulation sand production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: December 29, 2009
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Truncated recombinant major outer membrane protein antigen (R56) of orientia tsutsugamushi strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines
    Publication number: 20090311722
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulation sand production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Application
    Filed: December 27, 2007
    Publication date: December 17, 2009
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Truncated recombinant major outer membrane protein antigen (R56) of orientia tsutsugamushi strains karp, kato and gilliam and its use in antibody based detection assays and vaccines
    Publication number: 20080279881
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulation sand production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Application
    Filed: December 27, 2007
    Publication date: November 13, 2008
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Truncated recombinant major outer membrane protein antigen (r56) of strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines
    Patent number: 7335477
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: February 26, 2008
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Expression and refolding of truncated recombinant major outer membrane protein antigen (R56) of orientia tsutsugamushi and its use in antibody based detection assays and vaccines
    Patent number: 6699674
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi. The invention is useful for detecting prior exposure to scrub typhus and as a component in vaccine formulations.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: March 2, 2004
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Wei-Me Ching, Daryl J. Kelly, Gregory A. Dasch
  • Expression and refolding of truncated recombinant major outer membrane protein antigen (R56) of orientia tsutsugamushi and its use in antibody based detection assays and vaccines
    Publication number: 20030185837
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi. The invention is useful for detecting prior exposure to scrub typhus and as a component in vaccine formulations.
    Type: Application
    Filed: June 14, 2002
    Publication date: October 2, 2003
    Applicant: The United States of America as Represented by the Secretary of the Navy
    Inventors: Wei-Me Ching, Daryl J. Kelly, Gregory A. Dasch
  • Truncated recombinant major outer membrane protein antigen (R56) of orientia tsutsugamushi strains Karp, Kato and gilliam and its use in antibody based detection assays and vaccines
    Publication number: 20030165523
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Application
    Filed: April 12, 2002
    Publication date: September 4, 2003
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Expression and refolding of truncated recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi and its use in antibody based detection assays and vaccines
    Patent number: 6482415
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi. The invention is useful for detecting prior exposure to scrub typhus and as a component in vaccine formulations.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: November 19, 2002
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch