Abstract: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Abstract: The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Abstract: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Abstract: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Abstract: The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Abstract: The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Abstract: Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits due to ischemia or hypoxia such as those that frequently occur as a consequence of cardiac surgery under cardiopulmonary bypass, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, or amyotrophic lateral sclerosis (ALS).

Abstract: An environmental control system for the severely disabled provides a "pass through" mode that allows a system output to mimic or emulate a user controlled switch input. The pass through mode permits a single user controlled switch to be shared among multiple systems for the disabled. In the normal mode, the user controlled switch controls various control functions provided by the environmental control system. In the "pass through" mode, the environmental control system operates "transparently" and passes the switch closures through to an electronically-controlled switch that appears electrically like a manually actuated switch to control other equipment for the disabled. The pass through mode is exited upon user actuation of the user controlled switch for more than a programmed time period and/or automatically upon occurrence of certain events (e.g., telephone ringing detection).

Abstract: An environmental control system for the handicapped provides a user interface which is totally integrated and programmable. An audible nested control option selection structure organizes logically related tasks and subtasks together so the user can access the tasks and subtasks in a natural fashion--providing an easy to learn user interface that is user friendly, minimizes frustration in accomplishing desired tasks, and also minimizes the time required to perform even complex control operations. Enhanced user interface features, including time encoding of control switch functions and synthesized speech prompting, further increases ease of operation and functionality. Interaction between different control channels allows the user to perform different tasks simultaneously. Enhanced telephone line manipulation is provided, including off-line assembly of telephone numbers for dialing which can be stored and easily accessed by the user through the unified audible sub-menu structure.

Abstract: An environmental control system for the handicapped provides a user interface which is totally integrated and programmable. An audible nested control option selection structure organizes logically related tasks and subtasks together so the user can access the tasks and subtasks in a natural fashion--providing an easy to learn user interface that is user friendly, minimizes frustration in accomplishing desired tasks, and also minimizes the time required to perform even complex control operations. Enhanced user interface features, including time encoding of control switch functions and synthesized speech prompting, further increases ease of operation and functionality. Interaction between different control channels allows the user to perform different tasks simultaneously. Enhanced telephone line manipulation is provided, including off-line assembly of telephone numbers for dialing which can be stored and easily accessed by the user through the unified audible sub-menu structure.