Abstract: Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a system for use in occluding an opening in the tissue of a body includes a handle, a catheter coupled with the handle and a medical device disposed within a lumen of the catheter. The medical device includes an anchor system having a plurality of anchor segments coupled with an anchor hub. The medical device further includes an occluder system having a plurality of occluder segments coupled with an occluder hub. A first actuator is configured to displace the occluder hub independent of, and relative to, the anchor hub to deploy the occluder system from a refracted state to an expanded state while the anchor system remains in a retracted state.

Abstract: Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a system for use in occluding an opening in the tissue of a body includes a handle, a catheter coupled with the handle and a medical device disposed within a lumen of the catheter. The medical device includes an anchor system having a plurality of anchor segments coupled with an anchor hub. The medical device further includes an occluder system having a plurality of occluder segments coupled with an occluder hub. A first actuator is configured to displace the occluder hub independent of, and relative to, the anchor hub to deploy the occluder system from a refracted state to an expanded state while the anchor system remains in a retracted state.

Abstract: Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a system for use in occluding an opening in the tissue of a body includes a handle, a catheter coupled with the handle and a medical device disposed within a lumen of the catheter. The medical device includes an anchor system having a plurality of anchor segments coupled with an anchor hub. The medical device further includes an occluder system having a plurality of occluder segments coupled with an occluder hub. A first actuator is configured to displace the occluder hub independent of, and relative to, the anchor hub to deploy the occluder system from a refracted state to an expanded state while the anchor system remains in a retracted state.

Abstract: Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a system for use in occluding an opening in the tissue of a body includes a handle, a catheter coupled with the handle and a medical device disposed within a lumen of the catheter. The medical device includes an anchor system having a plurality of anchor segments coupled with an anchor hub. The medical device further includes an occluder system having a plurality of occluder segments coupled with an occluder hub. A first actuator is configured to displace the occluder hub independent of, and relative to, the anchor hub to deploy the occluder system from a refracted state to an expanded state while the anchor system remains in a retracted state.

Abstract: A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a body portion operatively associated with a first anchor and a second anchor. The body portion can include a plurality of segments defining a multi-cellular structure. The closure device can be configured to apply lateral force to tissue of the internal tissue opening to bring tissue together. The closure device can have a substantially flat aspect, and have a depth thickness that is substantially greater than the thickness or width of a majority of the members forming the closure device to reduce out of plane bending. The closure device can also include a member adapted to induce tissue growth.

Abstract: A filter device is adapted to function as a guidewire, an exchange guidewire, and provide embolic protection during a procedure. The filter device includes a filter assembly that is either integral with or coupled to a guide member. The filter assembly includes a plurality of struts that expand outwardly to deploy a filter that collects or captures material flowing along the blood vessel within which the filter device is deployed. The plurality of struts are constrained by a restraining member or mechanism that prevents the plurality of struts from expanding or extending outwardly to deploy the filter. Cooperating with the restraining member or mechanism is an actuating assembly that is adapted to release the restraining member or mechanism and enable the filter to be deployed from the guide member. A capture catheter is cooperates with the filter device and substantially surrounds the filter during removal of the filter device.

Abstract: A medical device for use in delivering RF energy to a tissue opening is disclosed. In one embodiment, the medical device comprises a compliant electrode. The compliant electrode can include a shape memory material, such as NITINOL, to facilitate the electrode having at least one relaxed orientation. The electrode can be deployed from a delivery shaft inside the left atrium, for example, of a heart through the delivery shaft. The electrode can be configured to substantially conform to the tissue proximate the tissue opening. After energy is applied to the tissue between the left and right electrodes, the left electrode can be removed from the left atrium by being received back into the delivery shaft and the delivery shaft thereafter removed from the opening.

Abstract: A medical device and system for modifying a left atrial appendage (“LAA”), as well as related methods, are provided. In accordance with one embodiment, a medical device includes a plurality of discrete frame segments coupled with at least one ring member to form a frame structure. Each discrete frame segment includes an expanding leg, a collapsing leg and a hub extension. A tissue growth member is coupled with the plurality of discrete frame segments to define a substantially convex surface and a substantially concave surface.

Abstract: Medical devices, systems and methods for modifying a left atrial appendage (“LAA”). In one embodiment, a medical device system includes a jailing member or structure positioned over the ostium of an LAA and at least one tissue growth member positioned within the LAA and retained within the LAA by the jailing member. In another embodiment, a medical device includes an atrial stent coupled with a patch that is configured to cover the ostium of an LAA. The patch may have a tissue growth member associated therewith. In another embodiment, the patch may include an open-cell frame which may be used as a jailing member or structure.

Abstract: A delivery device adapted to insert and deploy a stent within a body lumen. The delivery device includes a guide member adapted to retain a dilation assembly and a stent within a lumen thereof until the stent is to be deployed into the body lumen. The delivery device is configured to enable simultaneous insertion of the guide member, dilation assembly, stent, and optional guidewire within a body lumen. Following deploying the stent, the delivery device can be removed, while providing the capability of optionally maintaining the guide member or the guidewire to function or act as an exchange wire for additional surgical devices.

Abstract: A delivery device adapted to insert and deploy a stent within a body lumen. The delivery device includes a guide member adapted to retain a dilation assembly and a stent within a lumen thereof until the stent is to be deployed into the body lumen. The delivery device is configured to enable simultaneous insertion of the guide member, dilation assembly, stent, and optional guidewire within a body lumen. Following deploying the stent, the delivery device can be removed, while providing the capability of optionally maintaining the guide member or the guidewire to function or act as an exchange wire for additional surgical devices.

Abstract: Disclosed is a constraining mechanism that enhances the strength of a medical device, while also preventing over expansion of the device, during a procedure. The medical device includes a plurality of biased struts to which a constraining mechanism is coupled. The constraining mechanism includes a spine, which couples to one of the plurality of struts, and one or more branches extending from the spine. The branches have a curvature enabling the branches to substantially surround the plurality of struts while at the same time avoiding contact with the wall of the blood vessel of the patient when the medical device is deployed.

Abstract: Devices, systems and methods for retrieving clot material from a vasculature lumen are provided. In one embodiment, a medical device includes a handle, a catheter, a tether member and a clot retrieval element. The catheter extends from the handle and the clot retrieval element is configured to be positioned within a distal portion of the catheter with the tether member extending between the handle and the clot retrieval element. The clot retrieval element is configured to be deployed from within the catheter so that the catheter moves proximally relative to and separate from the clot retrieval element while maintaining attachment to the clot retrieval element via the tether member. Further, the clot retrieval element is configured to be pulled by the tether member to abut against a distal side of a clot with proximal movement of the tether member to pull the clot from the vasculature lumen.

Abstract: The present invention is directed to various embodiments of medical devices and methods for occluding a fallopian tube for contraception and permanent sterilization. In one embodiment, the medical device includes an outer member, an inner member and a tissue growth member. The outer member includes an outer surface and an inner surface, wherein the inner surface defines a bore in the outer member. The inner member is configured to be positioned within the bore of the outer member. The tissue growth member is attached to the outer surface of the outer member and is configured to induce tissue growth thereto. With this arrangement, the medical device can be implanted within the fallopian tube and serve as a permanent occluding device therein. If desired, the medical device can be partially removed from the fallopian tube to restore the ability for conception.

Abstract: An apparatus, method and system directed to treatment of aneurysms are disclosed. In one embodiment a medical device delivery system may include a handle, a controller coupled to the handle and a catheter coupled to the handle. The delivery system may also include multiple embolic elements. Each of the embolic elements are positioned in a distal portion of the catheter in a compressed configuration and lined in a row within the distal portion of the catheter. The embolic elements are configured to be separately and discretely released from the catheter to be freely and randomly positioned within an aneurysm cavity and are each configured to self expand to an configuration larger in size than the compressed configuration.

Abstract: A delivery device adapted to insert and deploy a stent within a body lumen. The delivery device includes a guide member adapted to retain a dilation assembly and a stent within a lumen thereof until the stent is to be deployed into the body lumen. The delivery device is configured to enable simultaneous insertion of the guide member, dilation assembly, stent, and optional guidewire within a body lumen. Following deploying the stent, the delivery device can be removed, while providing the capability of optionally maintaining the guide member or the guidewire to function or act as an exchange wire for additional surgical devices.

Abstract: Medical devices, systems and methods for treating valve prolapse in, for example, the mitral valve. The medical device is employed by delivering the device percutaneously and lodging the device adjacently above the valve. With this arrangement, the device provides a back-stop to prevent valve prolapse and, thus, prevent valve regurgitation.

Abstract: Embodiments of the present invention are directed to ablation catheter systems configured, for example, to ablate tissue adjacent an ostium of the pulmonary vein in a left atria of a heart. In one embodiment, an ablation catheter system includes a handle including an actuator and a catheter coupled to the handle defining a lumen extending through a length of the catheter, the catheter including a tip portion at a distal end thereof. The ablation catheter system may also include an electrode coupled to the handle with lines extending through the lumen of the catheter, the electrode being configured to be constrained within the tip portion of the catheter and configured to be deployed from the tip portion and self expand to an expanded configuration. With this arrangement, the electrode is configured to self expand to a conical configuration with a tip portion configured to be disposed within the pulmonary vein.

Abstract: Several embodiments are set forth of devices, systems and methods for modifying an atrial appendage such as a left atrial appendage (LAA). In one embodiment, a device includes a body that is collapsible and self-expanding. The body includes a textured surface with protruding portions and recessed portions. The body may be formed of a reticulated foam material and may exhibit a substantially spherical geometry or a truncated spherical geometry. The body may be substantially hollow. In one embodiment, portions of the textured surface may be metalized or have a coating placed thereon to enhance frictional engagement of the body with the atrial appendage wall. In another embodiment, a mesh bag is disposed within an LAA and one or more self-expanding bodies are disposed within the mesh bag. The mesh bag is then secured to retain the self-expanding bodies within the bag and the LAA.

Abstract: A stitching device and method of operating the stitching device to form an embolic protection device is disclosed. The stitching device includes a clamping assembly and an advancing assembly. The clamping assembly holds a restraining member about a filter assembly while the advancing assembly threads or stitches a securing member through the restraining member. The clamping assembly includes a first clamping portion and a second clamping portion, each having an upper row of teeth and a lower row of teeth divided by a channel. The advancing assembly includes a threading assembly with an engagement member for engaging and advancing the securing member.