Patents by Inventor Dat Q. Tran

Dat Q. Tran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250230192
    Abstract: Uses of novel peptide analogs of a ?-defensin that have been developed which provide a biphasic effect in treating infection and/or sepsis are described. These analogs are active at concentrations below those needed to provide a bactericidal or bacteriostatic effect, and function by initially recruiting effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response characteristic of sepsis and septic shock. These novel ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensin.
    Type: Application
    Filed: October 14, 2024
    Publication date: July 17, 2025
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal
  • Publication number: 20250215054
    Abstract: Novel peptide analogs of a ?-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. These novel ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensins.
    Type: Application
    Filed: October 12, 2024
    Publication date: July 3, 2025
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal, Virginia Basso
  • Publication number: 20250041381
    Abstract: Compositions and methods that provide safe and effective prophylactic treatment of a wide range of microbial pathogens are described. Such compositions and methods incorporate ? defensins and analogs of ? defensins, which have broad antimicrobial effects, have been found to maintain effective concentrations in the blood stream for extended periods of time, and are safe to administer at high doses.
    Type: Application
    Filed: November 1, 2022
    Publication date: February 6, 2025
    Inventors: Michael E. Selsted, Justin B. Schaal, Patti Tran, Dat Q. Tran
  • Patent number: 12186368
    Abstract: A method is provided for a condition related to the activity of a protease through the administration of a ?-defensin, analog, or derivative is described. Suitable proteases include metalloproteases and cysteine proteases such as Cathepsin-C. The ?-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: January 7, 2025
    Assignee: The Regents of the University of California
    Inventors: Michael E. Selsted, Dat Q. Tran
  • Publication number: 20240391970
    Abstract: Peptide analogs of a ?-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. These ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensins.
    Type: Application
    Filed: May 21, 2024
    Publication date: November 28, 2024
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal, Virginia Basso
  • Patent number: 12146005
    Abstract: Novel peptide analogs of a ?-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. These novel ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensins.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: November 19, 2024
    Assignee: University of Southern California
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal, Virginia Basso
  • Publication number: 20240293507
    Abstract: Compositions and methods for enhancing immune checkpoint inhibitor therapy of cancer by cotherapy with cyclic peptides are provided. Such cyclic peptides can be naturally occurring or of synthetic origin.
    Type: Application
    Filed: May 20, 2024
    Publication date: September 5, 2024
    Inventors: Michael E. SELSTED, Dat Q. TRAN, Jagadish KRISHNAPPA
  • Patent number: 12012440
    Abstract: Peptide analogs of a ?-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. These ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensins.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: June 18, 2024
    Assignee: The University of Southern California
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal, Virginia Basso
  • Publication number: 20240108702
    Abstract: Methods for treating and/or SARS-CoV-2 infection are described that inhibit viral replication, multiple protease activities, and provide anti-inflammatory activity. Such activities can be provided by a single species, such as a naturally occurring cyclic peptide.
    Type: Application
    Filed: January 12, 2022
    Publication date: April 4, 2024
    Inventors: Michael E. Selsted, Dat Q. Tran, Patti Tran, Justin B. Schaal, Virginia Basso, Prasad Tongaonkar
  • Publication number: 20230072433
    Abstract: Novel peptide analogs of a ?-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. These novel ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensins.
    Type: Application
    Filed: July 20, 2022
    Publication date: March 9, 2023
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal, Virginia Basso
  • Publication number: 20230038720
    Abstract: Peptide analogs of ?-defensins have been developed that are effective in treating multi-drug resistant microbial infections when used at concentrations below those needed to provide a microbicidal effect. These peptides were found to modulate host defense mechanisms to increase clearance of microbial pathogens, enhance phagocytic activity, and enhance neutrophil recruitment while reducing inflammation.
    Type: Application
    Filed: September 20, 2022
    Publication date: February 9, 2023
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal
  • Patent number: 11510425
    Abstract: Formulations that, when suitably mixed, form edible liquid solutions suitable for blowing bubbles. These formulations contain water, a surfactant, a thickener, a pH adjusting agent/preservative, and optionally a sweetener. The formulations may be provided in either solid form or liquid form, either of which may form an edible bubble solution when mixed with a sufficient quantity of a beverage or similar liquid.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: November 29, 2022
    Inventor: Dat Q. Tran
  • Patent number: 11427617
    Abstract: Novel peptide analogs of a ?-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. These novel ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensins.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: August 30, 2022
    Assignee: THE UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal, Virginia Basso
  • Publication number: 20210403523
    Abstract: Peptide analogs of a ?-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. These ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensins.
    Type: Application
    Filed: June 25, 2021
    Publication date: December 30, 2021
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal, Virginia Basso
  • Publication number: 20210261623
    Abstract: Uses of novel peptide analogs of a ?-defensin that have been developed which provide a biphasic effect in treating infection and/or sepsis are described. These analogs are active at concentrations below those needed to provide a bactericidal or bacteriostatic effect, and function by initially recruiting effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response characteristic of sepsis and septic shock. These novel ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensin.
    Type: Application
    Filed: May 7, 2021
    Publication date: August 26, 2021
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal
  • Patent number: 11021518
    Abstract: Novel peptide analogs of a ?-defensin have been developed that provide a biphasic effect in treating infection and/or sepsis. These analogs are active at concentrations below those needed to provide a bactericidal or bacteriostatic effect, and function by initially recruiting effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response characteristic of sepsis and septic shock. These novel ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensin.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: June 1, 2021
    Assignee: The University of Southern California
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal
  • Publication number: 20200407400
    Abstract: Novel peptide analogs of a ?-defensin have been developed that provide a biphasic effect in treating infection and/or sepsis. These analogs are active at concentrations below those needed to provide a bactericidal or bacteriostatic effect, and function by initially recruiting effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response characteristic of sepsis and septic shock. These novel ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensin.
    Type: Application
    Filed: June 26, 2020
    Publication date: December 31, 2020
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal
  • Publication number: 20200407399
    Abstract: Novel peptide analogs of a ?-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. These novel ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensins.
    Type: Application
    Filed: June 26, 2020
    Publication date: December 31, 2020
    Inventors: Michael E. Selsted, Dat Q. Tran, Justin B. Schaal, Virginia Basso
  • Publication number: 20200333024
    Abstract: A method is provided for a condition related to the activity of a protease through the administration of a ?-defensin, analog, or derivative is described. Suitable proteases include metalloproteases and cysteine proteases such as Cathepsin-C. The ?-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally.
    Type: Application
    Filed: March 20, 2020
    Publication date: October 22, 2020
    Inventors: Michael E. Selsted, Dat Q. Tran
  • Patent number: 10603356
    Abstract: A method is provided for treating bowel disease related to the activity of TNF-?, through the administration of a ?-defensin, analog, or derivative. Such a ?-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally. The ?-defensin, analog, or derivative can be selected to additionally inhibit ADAM-10 activity.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: March 31, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michael E. Selsted, Dat Q. Tran