Abstract: Compositions of polynucleotide(s) are disclosed. A polynucleotide may encode for a polypeptide, protein, or functional fragment thereof associated with primary ciliary dyskinesia (PCD). Pharmaceutical compositions, kits, and methods for treating a disease or condition associated with cilia maintenance and function, and impaired function of the axoneme are also disclosed. The polynucleotide may be combined with a lipid composition.

Abstract: A method for producing an easy open, easy tear package formed of flexible single layer or multi-layered material using a laser. The user configures a microprocessor with the sheet size, score pattern, and material parameters. The microprocessor controls the laser to score the film material to a depth less than a full depth of the material. The microprocessor modulates the laser to create tear initiation areas at predetermined locations precisely on the score line, so as to create a starting point for initiating a tear to open the package along the score line after the package is sealed.