Abstract: A system for mixing powdered materials includes a cannula and an actuator adapted to vibrate the cannula. An optional fluid delivery system is operable to add fluid to the powdered mixture through the cannula. The cannula can be extended into a powder bed and vibrated by the actuator to mix the powder bed. Fluid can be added to the powder bed through the cannula. The systems and methods are suitable for preparing relatively small quantities of candidate mixtures for high-throughput screening. Sample mixtures prepared by the mixing system can be pressed into tablets that are substantially devoid of foreign objects used to mix the samples. The sample mixtures can be subjected to one or more tests, such as an accelerated aging or forced degradation test, to assess one or more characteristics of the sample mixtures.

Abstract: The invention relates to an electronic circuit comprising a first comparator having a first input offset voltage, wherein the first comparator is operatively coupled to a first sampling capacitor, a second comparator having a second input offset voltage, wherein the second comparator is operatively coupled to a second sampling capacitor, and a control circuit operatively coupled to the first comparator and the second comparator for generating alternate cycles having a first phase and a second phase, wherein a first sampled offset voltage is stored in the first sampling capacitor during the first phase of the alternate cycles, wherein the first sampled offset voltage is subtracted from the first input offset voltage during the second phase of the alternate cycles, wherein a second sampled offset voltage is stored in the second sampling capacitor during the second phase of the alternate cycles, and wherein the second sampled offset voltage is subtracted from the second input offset voltage during the first phas

Abstract: A cannula for use in transferring small volumes of fluid materials, such as in a parallel reaction process. The cannula comprises a long thin needle having various end (port) configurations, and an adapter for connecting the needle to a fluid line. The adapter may include the combination of a reservoir and transition, or simply a transition.

Abstract: An apparatus for parallel processing of multiple reaction mixtures comprises a plurality of reactor vessels for holding reaction mixtures at pressures of at least about 15 psig. Cannula passages communicate with respective vessels, and a cannula is adapted to be inserted into each cannula passage. A sealing mechanism, comprising a valve and a seal, in each cannula passage maintains a respective vessel sealed when the cannula is inserted into and withdrawn from the cannula passage. A robot system is operable to insert the cannula to a location where a distal end and port of the cannula are past the open valve and seal, and to withdraw the cannula. Methods for transferring fluid reaction material to and from a series of pressurized vessels, establishing fluid communication between a cannula and a vessel of a combinatorial chemistry reactor and establishing fluid communication between a cannula and a series of pressurized vessels of a combinatorial chemistry reactor are also disclosed.

Abstract: A cannula for use in transferring small volumes of fluid materials, such as in a parallel reaction process. The cannula comprises a long thin needle having various end (port) configurations, and an adapter for connecting the needle to a fluid line. The adapter may include the combination of a reservoir and transition, or simply a transition.