Abstract: Methods, systems, devices and compounds for managing imaging data, such as time series imaging data. The method may include selecting a set of representative voxels from a plurality of voxels in the imaging data, and associating each representative voxel with a voxel database for storing information. For each given voxel in the time series imaging data, at least one corresponding representative voxel may be determined from the set of representative voxels, and information from the given voxel may be aggregated in the voxel database of the determined corresponding representative voxel.