Abstract: A computer implemented method and apparatus for determining an optimal time and channel for delivery of television advertising content based on viewer profile information collects viewer profile information for a viewer and stores it in a computer memory. Definitions of modal segments of viewers in terms of one or more viewer profile information thresholds are also stored and the viewer is assigned to one or more modal segments based on a comparison of the viewer profile information thresholds with the collected viewer profile information. The optimal time and channel for delivery of television advertising content is determined based on the viewer's assignment to the modal segments, the collected viewer profile information, and promoted program information; and the determined optimal time and channel for delivery of the television advertising content is provided for display.

Abstract: A computer implemented method and apparatus for determining an optimal time and channel for delivery of television advertising content based on viewer profile information is disclosed. The method and apparatus provide for collecting viewer profile information for a viewer and storing it in a computer memory. Segments of viewers may be defined by viewer profile information thresholds in the computer memory. Viewers may be assigned to an audience segment based on a comparison of the viewer profile information thresholds with the collected viewer profile information. Information describing programs to be promoted, spots in which promotions for such programs may air, and geographic data also may be collected and stored. The computer may determine an optimal time and channel for delivery of the television advertising content to a selected audience segment based on the program to be promoted information, spot information and geographic data.

Abstract: Disclosed is a method for the treatment of a neurodegenerative disorder by isolating a plurality of monocytic cells and introducing a vector containing a gene that expresses a protease capable of degrading amyloid peptide into the isolated monocytic cells. The modified cells are then administered to the patient. Preferably the introduced gene is selected from the group consisting of neprilysin, insulin degrading enzyme and endothelin converting enzyme. The protease capable of degrading amyloid peptide is secreted from the monocytic cells into the extracellular space thereof. According to one variant, the gene that expresses a protease capable of degrading amyloid peptide is the NEP gene with a deletion in the membrane binding domain and/or an appended signal peptide to drive secretion of the modified gene product. This invention contemplates the use of heterologous and autologos (the monocytic cells are obtained from the patient) transplants.

Abstract: A computer implemented method and apparatus for determining an optimal time and channel for delivery of television advertising content based on viewer profile information is disclosed. The method and apparatus provide for collecting viewer profile information for a viewer and storing it in a computer memory. Segments of viewers may be defined by viewer profile information thresholds in the computer memory. Viewers may be assigned to an audience segment based on a comparison of the viewer profile information thresholds with the collected viewer profile information. Information describing programs to be promoted, spots in which promotions for such programs may air, and geographic data also may be collected and stored. The computer may determine an optimal time and channel for delivery of the television advertising content to a selected audience segment based on the program to be promoted information, spot information and geographic data.