Patents by Inventor Dave REMILLARD

Dave REMILLARD has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIFUNCTIONAL DEGRADERS COMPRISING ELECTROPHILIC PROTACS THAT ENGAGE DCAF1 AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
    Publication number: 20260083722
    Abstract: Disclosed are bifunctional degraders comprising electrophilic PRO-TACs that engage DCAF1 and pharmaceutical compositions comprising the same. The bifunctional degraders are of Formula A-B-C wherein, A is a ligand to a protein of interest, B is a linker that is a bond or a chemical linker that is chemically linked to A and C, and C is a ligand to the E3 ligase substrate receptor DCAF1, wherein the protein of interest is any protein having a ligand that can form a covalent bond with the linker B; and C comprises an azetidinyl acrylamide that forms a covalent bond with C1113 of DCAF1 through a Michael addition reaction.
    Type: Application
    Filed: May 19, 2023
    Publication date: March 26, 2026
    Inventors: Benjamin F. CRAVATT, Yongfeng TAO, Xiaoyu ZHANG, Dave REMILLARD, Ekaterina VINOGRADOVA, Minoru YOKOYAMA, Bruno MELILLO, Stuart SCHREIBER
  • AN ACTIVITY-GUIDED MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS
    Publication number: 20240131032
    Abstract: Disclosed herein are methods, pharmaceutical compositions, and vaccines for modulating an immune response. Also disclosed herein are methods, pharmaceutical compositions, and vaccines for inducing an immune response.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 25, 2024
    Inventors: Benjamin CRAVATT, Ekaterina VINOGRADOVA, Vincent CROWLEY, Xiaoyu ZHANG, Michael Andreas SCHAFROTH, Minoru YOKOYAMA, Dave REMILLARD, Bruno MELILLO, Stuart SCHREIBER