Patents by Inventor Dave S. B. Hoon

Dave S. B. Hoon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7588894
    Abstract: Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis. Further, aberrant hypermethylation of ID4 gene promoter region increases risk of metastasis in colorectal and breast cancer.
    Type: Grant
    Filed: February 1, 2006
    Date of Patent: September 15, 2009
    Assignee: John Wayne Cancern Institute
    Inventors: Dave S. B. Hoon, Naoyuki Umetani
  • Patent number: 6472375
    Abstract: DNA cancer vaccines and methods for their use are described. The vaccines are comprised of viral liposomes comprising nucleic acid, preferably DNA, encoding a tumor-associated antigen. The viral liposomes may be formed by the fusion of HVJ reagents with nonviral reagents. The vaccine may be administered subcutaneously, intradermally, intramuscularly or into an organ. The vaccine may be administered to induce a host normal cell to express the tumor associated antigen.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: October 29, 2002
    Assignee: John Wayne Cancer Institute
    Inventors: Dave S. B. Hoon, Yasufumi Kaneda
  • Patent number: 6465177
    Abstract: A method is provided for assessing allelic losses on specific chromosomal regions in melanoma patents. The method relies on the evidence that free DNA may be released in the plasma/serum of cancer patients allowing the detection of DNA with LOH in the plasma/serum of cancer patients by analysis for microsatellite markers. The amount of and specific allelic loss allows a prognosis to be made regarding tumor diagnosis and progression, tumor metastasis, tumor recurrence, and mortality.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: October 15, 2002
    Assignee: John Wayne Cancer Institute
    Inventor: Dave S. B. Hoon
  • Patent number: 6432925
    Abstract: RNA cancer vaccines and methods for their use are described. The vaccines are comprised of viral liposomes comprising nucleic acid, preferably RNA, encoding a tumor-associated antigen. The viral liposomes may be formed by the fusion of HVJ reagents with nonviral reagents. The vaccine may be administered subcutaneously, intradermally, intramuscularly or into an organ. The vaccine may be administered to induce a host normal cell to express the tumor associated antigen.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: August 13, 2002
    Assignee: John Wayne Cancer Institute
    Inventors: Dave S. B. Hoon, Yasufumi Kaneda
  • Patent number: 6057105
    Abstract: Methods for detecting metastasis of melanoma and breast cancer cells, detecting subclinical metastasis, and monitoring treatment are disclosed. Kits for use in such methods also are disclosed. The methods provide for the detection of nucleic acids corresponding to multiple melanoma or breast cancer specific markers using template dependent amplification processes. Methods using multiple markers provide increased sensitivity over existing methods.
    Type: Grant
    Filed: December 9, 1997
    Date of Patent: May 2, 2000
    Assignee: NGI/Cancer Tech Company, LLC
    Inventors: Dave S. B. Hoon, Andrew J. Conrad, Peter Schmid