Abstract: An electro-pneumatic assembly for use in a respiratory measurement system that includes a housing having a plurality of channels defined therein and a plurality of walls forming a cavity. The housing includes an upper face, a lower face, and a plurality of apertures defined in the lower face of the housing to. A cover is affixed to the upper face of the housing to enclose the cavity thereby forming a chamber, and to enclose the channels thereby forming a plurality of conduits. A control component is operatively coupled to at least one aperture in the plurality of apertures, and a measurement component is operatively coupled to at least one aperture in the plurality of apertures. This assembly provides a simple, robust component for managing the pneumatics of the respiratory measurement system.