Patents by Inventor Daved H. Fremont

Daved H. Fremont has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SINGLE CHAIN CONSTRUCTS
    Publication number: 20220047710
    Abstract: Fusion proteins are provided, the fusion proteins comprising a single-chain trimer coupled to an Fc domain of an antibody. Also provided are methods of use thereof.
    Type: Application
    Filed: September 12, 2019
    Publication date: February 17, 2022
    Applicant: Washington University
    Inventors: Chang Liu, Daved H. Fremont, Brian Edelson, Christopher A. Nelson, Xiaoli Wang
  • Crystals and structure of domain III of West Nile Virus envelope protein in association with a Fab fragment of a neutralizing antibody
    Patent number: 7498419
    Abstract: The present invention provides crystalline forms of domain III of the West Nile Virus (“WNV”) envelope protein in complex with a Fab fragment of a neutralizing antibody, methods of obtaining such crystals and high-resolution structures and atomic structure coordinates. The crystals of the invention and the atomic structural information are useful for solving crystal and solution structures of related and unrelated proteins, and for screening for, identifying or designing compounds or antibodies that bind to, modulate a biological activity of, or neutralize infection mediated by flaviviral envelope proteins.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: March 3, 2009
    Assignee: Washington University
    Inventors: Daved H. Fremont, Grant Nybakken, Michael Diamond
  • Crystal forms and mutants of RANK ligand
    Publication number: 20030050223
    Abstract: The present invention provides crystals of RANKL ectodomain complexes, detailed three dimensional structural information illustrating the interaction between RANKL and RANK and methods of utilizing the X-ray crystallographic data from such crystals and other structural data disclosed to design, identify and screen for compounds that modulate activity. The present invention also relates to machine readable media embedded with the three-dimensional atomic structure coordinates of RANKL crystalline complexes and subsets thereof, together with other structural data disclosed herein.
    Type: Application
    Filed: August 9, 2002
    Publication date: March 13, 2003
    Inventors: Jonathan Lam, F. Patrick Ross, Steven L. Teitelbaum, Christopher A. Nelson, Daved H. Fremont