Patents by Inventor David A. Berges

David A. Berges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Water soluble camptothecin analogs
    Patent number: 6046209
    Abstract: The present invention provides water soluble camptothecin analogs of Formula I: ##STR1## which are particularly useful as antineoplastic agents; pharmaceutical compositions thereof; and a method of treating cancer in an animal in need thereof, including human beings, comprising inhibition of the growth of tumor cells in said animal by administration of an effective amount of a compound of Formula I.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: April 4, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: David A. Berges, John J. Taggart
  • Water soluble camptothecin analogs
    Patent number: 5670500
    Abstract: The present invention provides water soluble camptothecin analogs of Formula I: ##STR1## which are particularly useful as antineoplastic agents; pharmaceutical compositions thereof; and a method of treating cancer in an animal in need thereof, including human beings, comprising inhibition of the growth of tumor cells in said animal by administration of an effective amount of a compound of Formula I.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 23, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: David A. Berges, John J. Taggart
  • Water soluble camptothecin analogs
    Patent number: 5663177
    Abstract: The present invention provides a water soluble camptothecin analog of Formula I: ##STR1## which is particularly useful as an antineoplastic agent; pharmaceutical compositions thereof; and a method of treating cancer in an animal in need thereof, including human beings, comprising inhibition of the growth of tumor cells in said animal by administration of an effective amount of a compound of Formula I.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 2, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: David A. Berges, John J. Taggart
  • 7-[2-Alkoxyimino-2-(amino-thiazole)acetami do]-3-[1-(sulfaminoalkly)tetrazolthiomethyl]cephalosporins
    Patent number: 4308267
    Abstract: Novel cephalosporins with improved antibacterial and pharmacokinetic properties are disclosed. These compounds have a 2-alkoxyimino-2-(2-amino-4-thiazolyl)-acetamido group at position 7 and a sulfaminoalkyltetrazolythio group at position 3.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: December 29, 1981
    Assignee: SmithKline Corporation
    Inventors: David A. Berges, George L. Dunn
  • 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
    Patent number: 4286089
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 27, 1974
    Date of Patent: August 25, 1981
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acylamino-3-(substituted tetrazolyl thiomethyl) cephalosporins
    Patent number: 4220644
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: September 2, 1980
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Phosphonoalkyl and esterified phosphonoalkyl substituted tetrazole thiols
    Patent number: 4211703
    Abstract: The compounds of this invention are phosphonoalkyl and esterified phosphonoalkyl substituted tetrazole thiols useful for preparing antibacterially active 7-acylamino-3-(phosphonoalkyl and esterified phosphonoalkyl substituted tetrazolylthiomethyl)cephalosporins.
    Type: Grant
    Filed: August 14, 1978
    Date of Patent: July 8, 1980
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acylamino-3-[1-[2-(carboxymethylamino)ethyl]tetrazol-5-ylthio methyl]-3-cephem-4-carboxylic acids
    Patent number: 4210587
    Abstract: Novel cephalosporins having various acyl substituents at the 7-position and a carboxymethylaminoethyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: July 1, 1980
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Amino-3-(phosphonoalkyl and esterified phosphonoalkyl substituted tetrazolylthiomethyl)cephalosporins
    Patent number: 4189573
    Abstract: The compounds of this invention are 7-amino-3-(phosphonoalkyl and esterified phosphonoalkyl substituted tetrazolylthiomethyl)cephalosporins useful as intermediates for preparing antibacterially active 7-acylamino cephalosporins.
    Type: Grant
    Filed: August 14, 1978
    Date of Patent: February 19, 1980
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Sulfaminoalkyl substituted tetrazole thiol intermediates for preparing cephalosporins
    Patent number: 4178288
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: December 11, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 3-(Carboxymethyl)thio-1H-1,2,4-triazol-5-thione
    Patent number: 4174324
    Abstract: Novel cephalosporins having various acyl substituents at the 7-position and a carboxymethylthio substituted triazolylthiomethyl group at the 3-position of the cephem nucleus are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: November 13, 1979
    Assignee: Smithkline Corporation
    Inventor: David A. Berges
  • 1-(2-Sulfamidoethyl)-1,4-dihydro-5H-tetrazole-5-thione
    Patent number: 4174323
    Abstract: Novel cephalosporins having various acyl substituents at the 7-position and a sulfamidoethyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: November 13, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acylamino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins antibacterial compositions containing them and methods of treating bacterial infections with them
    Patent number: 4171362
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acylamino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them
    Patent number: 4171368
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Amino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporin intermediates for preparing 7-acylamino cephalosporins
    Patent number: 4171433
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins
    Patent number: 4159373
    Abstract: The compounds of this invention are cephalosporins having a 3- or 4-aminomethylphenylacetamido substituent at the 7-position and a sulfonic acid substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus. The compounds have antibacterial activity.
    Type: Grant
    Filed: April 4, 1978
    Date of Patent: June 26, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acylamino-3-(1-car boxymethylthioethyltetrazolyl-5-thiomethyl)-3-cephem-4-carboxylic acids
    Patent number: 4147701
    Abstract: New semisynthetic cephalosporins characterized by having structures with a 1-carboxymethylthioethyltetrazolyl-5-thiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-ceph em-4-carboxylic acid disodium salt.
    Type: Grant
    Filed: November 2, 1977
    Date of Patent: April 3, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 5-Sulfomethyl-1,3,4-thiadiazole-2-thiol
    Patent number: 4144241
    Abstract: A new intermediate used in the preparation of new semisynthetic cephalosporins is 5-sulfomethyl-1,3,4-thiadiazole-2-thiol which is prepared by a reaction sequence starting with p-methoxybenzyldithiocarbazate and chloroacetyl chloride.
    Type: Grant
    Filed: October 27, 1977
    Date of Patent: March 13, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Intermediates for the preparation of 7-acyl-3-(substituted triazolylthiomethyl)cephalosporins
    Patent number: 4142046
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted triazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: February 27, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Intermediates for preparing 7-acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolylthiomethyl)cephalosporins
    Patent number: 4140694
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 11, 1977
    Date of Patent: February 20, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges