Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.

Abstract: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.

Abstract: A system and method for energy efficient Ethernet (EEE) enhanced information technology power management tools. EEE-based computing center resources are designed to monitor energy savings events hardware components (e.g., physical layer device) included within the computing center resource. Energy saving statistics based on such monitoring can be provided to a power management tool. This monitoring information enables the power management tool to make broad service-level energy savings decisions on actual network activity. In addition, feedback based on the broad service-level energy savings decisions can be provided to the EEE-based computing center resources for consideration by their individual EEE control policies.

Abstract: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.

Abstract: A punch assembly for a punch press has a punch housing with a punch that is slideably mounted for reciprocation along punch axis within the punch housing and at least one resilient member in the housing for yieldably biasing the punch upwardly in the housing along the punch axis. A punch length adjustment subassembly is provided in the punch housing. The subassembly has a base member that is slideable axially but non-rotatably mounted within the housing and a punch head member having an upper end that is positioned to be struck by a punch ram of a punch press for driving the punch downwardly to an operating position. The punch head is mounted for rotation on the punch axis relative to the base member but is held against axial movement relative to the base member.

Abstract: A punch press tool for stamping successive multicharacter impressions into a workpiece such as a piece of steel, sheet metal, or other workpiece, includes a guide body in which a stamp driver is slidably mounted for being driven downwardly toward the workpiece by a punch press ram which is a standard part of a high speed commercial punch press. A multicharacter marking stamp is supported at the lower end of the stamp driver for reciprocal movement therewith. The marking stamp includes multicharacter wheels that are rotated automatically during operation for advancing characters in sequence responsive to the movement of a character advancing arm. At least one character stamp operating lever is operatively associated with the punch press tool for articulation responsive to motion imparted to the tool by the ram.

Abstract: The invention provides methods and compositions for reducing the number of cancer stem cells in a mixed population of differentiated cells (for example, cancer cells) and cancer stem cells. The cancer stem cells, if present, can be more resistant to traditional drug-based therapies and can provide a source for new, differentiated cancer cells associated with the development of drug-resistance and more aggressive phenotypes. When combined with traditional cancer therapies, for example, drug-based therapies, the methods and compositions of the invention provide a more effective way for treating cancer and can provide a model system for developing new cancer therapies and new treatment modalities.

Abstract: The specification discloses quenchers of excited state energy, probes and other conjugates comprising the same, and methods for their use. The quenchers of excited state energy have a structure comprising at least one reactive functional group for linking the quencher to a carrier molecule and at least three radicals covalently linked via exocyclic diazo bonds, the at least three radicals including at least one comprising a julolidine of the nominal formula: and the remainder of the at least three radicals being selected from the group of substituted and unsubstituted aryls, substituted and unsubstituted heteroaryls, and combinations thereof.

Abstract: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.

Abstract: A method and a system for generating image content. The method and system allow segments of a panoramic scene, to be generated with reduced distortion. The method and system reduce the amount of distortion by mapping pixel data onto a pseudo camera focal plane which is provided substantially perpendicularly to the focal location of the camera that captured the image. A camera arrangement can implement the method and system.

Abstract: Genetically engineered microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use.

Abstract: The present invention provides compositions and methods for use in treatment of premature rupture of membrane. The compositions of the invention include a therapeutic amount of an avian thick egg white composition. Preferably, the compositions include the purified thick egg white protein, ovomucin. The methods of the invention involve injecting an effective amount of the compositions into the prematurely ruptured amniotic sac of a patient in order to seal the rupture.

Abstract: A computer-implemented system and method for mortgage lending management and compliance receives, from a user, lending transaction data for a loan, property and a borrower; automatically determines if the loan complies with legal requirements and/or requires counseling based on the presence of one or more triggers (i.e., indicia of subprime or predatory lending) in the data, and notifying parties of the determination; and receives, from a counselor, counseling data for the loan and borrower. After any necessary counseling has been obtained and the counselor supplies all needed data, a certificate may be generated evidencing a counseling determination. The certificate may be transmitted to an office of a recorder for a jurisdiction in which the property is located. Suspicious activity may be flagged for appropriate investigation and remedial action by an administrator. Further progress may be halted until the administrator provides responsive input.

Abstract: The present invention provides compositions and methods for use in treatment of premature rupture of membrane. The compositions of the invention include a therapeutic amount of an avian thick egg white composition. Preferably, the compositions include the purified thick egg white protein, ovomucin. The methods of the invention involve injecting an effective amount of the compositions into the prematurely ruptured amniotic sac of a patient in order to seal the rupture.

Abstract: A myo-inositol derivative: R1, R2, R3 and R4 are identical, being selected from PO3H2, PO3Na2, PO3K2, PO3Li2, PO3Ca, PO3Mg, PO3(NH4)2, PO3(RNH3)2, PO3(R2NH2)2, PO3(R4N)2, PO(OR)2, H, COZ and BHPP, where R is benzyl or alkyl of 1 to 6 carbon atoms and Z is an alkyl or arylalky group providing a cleavable protecting group; R5 is one of H, benzyl, 4-methoxybenzyl, COZ, PO3H2, PO3Na2, PO3K2, PO3Li2, PO3Ca, PO3Mg, PO3(NH4)2, PO3(RNH3)2, PO3(R2NH2)2, PO3(R4N)2, PO(OR)2, and BHPP, where R is benzyl or alkyl of 1 to 6 carbon atoms and Z is an alkyl or arylalky group providing a cleavable protecting group; X is one of CH2, CH2CH2O, and CH2CH2CH2O; n is an integer from 1 to 8; L1 is a single bond or CH2; L2 is one of a single bond, CONH, CH2CONH, CH2CH2CONH, CH2CH2NHCO, CH2CH2NHCONH, CH2CH2NHCSNH, CH2CH2NHSO2, CH2CH2CH2NHCO, CH2CH2CH2NHCONH, CH2CH2CH2NHCSNH, CH2CH2CH2NHSO2, NHCO, NHCONH, NHCSNH, OCONH, CH2, CH2CH2, CH2CH2O, CH2CH2S, CH2CH2NH, CH2CH2CH2, CH2CH2CH2O, CH2CH2CH2S, CH2CH2CH2NH, and NH—SO2; and R6 is a U

Abstract: A system is provided. The system includes a media server that provides a media file to a computing device. Further, the system includes a metadata server that provides metadata corresponding to the media file to the computing device. The metadata includes (i) a plurality of x and y coordinates that indicate an interactive region of a display of the media file at a predetermined time and (ii) an instruction that is automatically triggered upon user interaction within the interactive region of the display of the media file. The interactive region includes an interactive region unique identifier. In addition, the system includes an interaction tracking server that receives interaction data and the interactive region unique identifier from the computing device. The interaction data including data corresponds to user interaction in the interactive region of the display of the media file.

Abstract: This invention relates, in part, to methods and compositions that modulate the stem cell environment. More specifically, the invention relates, in part, to methods and compositions for modulating stem cell differentiation. Therefore, methods and compositions are provided for modulating glycosaminoglycan moieties, e.g., heparan sulfate glycosaminoglycan (HSGAG) moieties, in the microenvironment of stem cells. Methods and compositions for promoting or inhibiting embryonic stem cell differentiation (e.g., differentiation into endothelial cells) are also provided. This invention also relates, therefore, in part, to cell populations (e.g., endothelial cell populations or impoverished endothelial cell populations) that can be produced with the methods and compositions provided. Furthermore, the invention relates, in part, to tissues, and uses thereof, formed by the methods and compositions provided. Moreover, the invention also relates, in part, to methods of treatment using the methods and compositions provided.

Abstract: Fluorous-tagged oligonucleotide reagents and an oligonucleotide purification methodology making use thereof, the method comprising: Synthesizing oligonucleotides using oligonucleotide reagents each bearing at least one fluorous group to yield a mixture of synthesis products and reagents, the mixture including at least one target synthesized oligonucleotide bearing at least one fluorous group; passing the mixture through a separation medium having an affinity for the at least one fluorous group so that the target synthesized oligonucleotide bearing at least one fluorous group is adsorbed by the separation medium; washing the separation medium with at least a first solvent to selectively dissociate therefrom substantially all synthesis products and reagents of the heterogenous mixture other than the at least one target synthesized oligonucleotide bearing at least one fluorous group; and subsequently dissociating the at least one synthesized oligonucleotide from the separation medium, with or without the fluorou

Abstract: This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.

Abstract: A retractor for use in surgery, has arms (2, 4) pivotal into a V-shaped configuration. Blades (16) are carried by the arms via mounting portions (16a) which can slide along the arms to provide adjustment in position with the blades being locked in that position simply by skewing the mounting portions on the arms.