Patents by Inventor David A. Bolten

David A. Bolten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6878557
    Abstract: A method for constructing an array of synthetic molecular constructs, by forming a plurality of molecular constructs having a scaffold backbone of a chemical molecule comprising a linear, branched or cyclic organic compound having at least atoms of carbon, nitrogen, sulfur, phosphorus, or combinations thereof, and at least one location on the molecule capable of undergoing reaction with other molecules for attachment of at least one structural diversity element; laying out an array possessing a logical ordering of sub-arrays of the molecular constructs; providing each sub-array with molecular constructs having the scaffold backbone and at least one structural diversity element which is different from the others; and relating each sub-array within the array to all other sub arrays by the difference in the structural diversity elements.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: April 12, 2005
    Assignee: ArQule, Inc.
    Inventors: Robert Zambias, David A. Bolten, Joseph C. Hogan, Paul Furth, David Casebier, Cheng Tu
  • Patent number: 5962736
    Abstract: A logically ordered array of 10,240 different compounds, each compound prepared from the reaction product of an oxazolone, aldehyde and amine.
    Type: Grant
    Filed: January 26, 1998
    Date of Patent: October 5, 1999
    Assignee: Arqule, Inc.
    Inventors: Robert Zambias, David A. Bolten, Joseph C. Hogan, Paul Furth, David Casebier, Cheng Tu
  • Patent number: 5807754
    Abstract: An n.times.m.times.p array of different chemical compounds, each having the following scaffold structure: ##STR1## wherein n, m and p are integers, A, B and C are organic structural moieties representing diversity elements. The novel compounds present in this array are useful as inhibitors of binding of Rev protein to a Rev response element.
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: September 15, 1998
    Assignee: Arqule, Inc.
    Inventors: Robert Zambias, David A. Bolten, Joseph C. Hogan, Paul Furth, David Casebier, Cheng Tu, Jaime E. Arenas
  • Patent number: 5736412
    Abstract: This invention is directed to an m.times.n array of different chemical compounds wherein each of said compounds has at least one structural diversity element selected from a group of amines and ketones and wherein the scaffold structure is selected from a group consisting of aminimide, imidazolone, sulfonylaminimide and phosphonylaminimide.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: April 7, 1998
    Assignee: ArQule, Inc.
    Inventors: Robert Zambias, David A. Bolten, Joseph C. Hogan, Paul Furth, David Casebier, Cheng Tu
  • Patent number: 5712171
    Abstract: A method for constructing an array of synthetic molecular constructs, by forming a plurality of molecular constructs having a scaffold backbone of a chemical molecule comprising a linear, branched or cyclic organic compound having at least atoms of carbon, nitrogen, sulfur, phosphorus, or combinations thereof, and at least one location on the molecule capable of undergoing reaction with other molecules for attachment of at least one structural diversity element; laying out an array possessing a logical ordering of sub-arrays of the molecular constructs; providing each sub-array with molecular constructs having the scaffold backbone and at least one structural diversity element which is different from the others; and relating each sub-array within the array to all other sub arrays by the difference in the structural diversity elements.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: January 27, 1998
    Assignee: ArQule, Inc.
    Inventors: Robert Zambias, David A. Bolten, Joseph C. Hogan, Paul Furth, David Casebier, Cheng Tu