Patents by Inventor David A. Botstein

David A. Botstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRO357 nucleic acids
    Patent number: 7368558
    Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: May 6, 2008
    Assignee: Genetech, Inc.
    Inventors: David Botstein, Audrey Goddard, Paul J. Godowski, Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Margaret Ann Roy, William I. Wood
  • Classification of patients having diffuse large B-cell lymphoma based upon gene expression
    Patent number: 7332280
    Abstract: Methods and kits for classifying patients having diffuse large B-cell lymphoma (DLBCL) based upon expression of a plurality of genes are disclosed. Real-time quantitative RT-PCR can be used to measure expression values. Correlating expression values of the plurality of genes in a tumor sample from the patient to reference expression values obtained from DLBCL patients can stratify patients in the classification groups. The methods and kits can be used to predict overall patient survival.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: February 19, 2008
    Inventors: Ronald Levy, Mark A. Wechser, Izidore S. Lossos, Robert J. Tibshirani, Ash A. Alizadeh, David Botstein
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7317092
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: January 8, 2008
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Kevin P. Baker, David A. Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Ivar J. Kljavin, Jennie P. Mather, Mary A. Napier, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Zemin Zhang
  • CARDIOTROPHIN-1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR
    Publication number: 20070274995
    Abstract: The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
    Type: Application
    Filed: September 29, 2006
    Publication date: November 29, 2007
    Applicant: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, David Lawrence, Diane Pennica, Margaret Roy, William Wood
  • Cardiotrophin-1 compositions and methods for the treatment of tumor
    Patent number: 7258983
    Abstract: The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: August 21, 2007
    Assignee: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, David A. Lawrence, Diane Pennica, Margaret Ann Roy, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7244816
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: July 17, 2007
    Assignee: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Margaret Ann Roy, Colin K. Watanabe, William I. Wood
  • CARDIOTROPHIN-1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR
    Publication number: 20070160618
    Abstract: The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
    Type: Application
    Filed: September 26, 2006
    Publication date: July 12, 2007
    Inventors: David Botstein, Audrey Goddard, David Lawrence, Diane Pennica, Margaret Roy, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7208308
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: April 24, 2007
    Assignee: Genentech, Inc.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Giang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Jennie P. Mather, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, P. Mickey Williams, William I. Wood
  • POLYPEPTIDES SHARING SEQUENCE IDENTITY WITH A FIBROBLAST GROWTH FACTOR POLYPEPTIDE AND NUCLEIC ACIDS ENCODING THE SAME
    Publication number: 20070077626
    Abstract: The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention. The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis and/or autocrine signaling.
    Type: Application
    Filed: December 14, 2006
    Publication date: April 5, 2007
    Applicant: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, Austin Gurney, Kenneth Hillan, David Lawrence, Margaret Roy
  • PRO363 polypeptides
    Patent number: 7196165
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: March 27, 2007
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Kevin P. Baker, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Sophia S. Kuo, Mary A. Napier, James Pan, Nicholas F. Paoni, Margaret Ann Roy, David L. Shelton, Timothy A. Stewart, Daniel Tumas, P. Mickey Williams, William I. Wood
  • PRO792 nucleic acids
    Patent number: 7189529
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: March 13, 2007
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Kevin P. Baker, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Sophia S. Kuo, Mary A. Napier, James Pan, Nicholas F. Paoni, Margaret Ann Roy, David L. Shelton, Timothy A. Stewart, Daniel Tumas, P. Mickey Williams, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7189530
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: March 13, 2007
    Assignee: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Margaret Ann Roy, Colin K. Watanabe, William I. Wood
  • PRO347 nucleic acids
    Patent number: 7189566
    Abstract: The present invention is directed to novel polypeptides having homology to cysteine-rich secretory protein-3 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cell comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: March 13, 2007
    Assignee: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, Paul Godowski, J. Christopher Grimaldi, Austin Gurney, Margaret Ann Roy, William Wood
  • Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity
    Publication number: 20070042395
    Abstract: The present invention is directed to novel polypeptides belonging to the fibroblast growth factor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Furthermore, methods of treating obesity are provided.
    Type: Application
    Filed: January 25, 2006
    Publication date: February 22, 2007
    Applicant: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, Austin Gurney, Kenneth Hillan, David Lawrence, Margaret Roy
  • WISP polypeptides and nucleic acids encoding same
    Publication number: 20070041964
    Abstract: Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
    Type: Application
    Filed: July 17, 2006
    Publication date: February 22, 2007
    Inventors: David Botstein, Robert Cohen, Audrey Goddard, Austin Gurney, Kenneth Hillan, David Lawrence, Arnold Levine, Diane Pennica, Margaret Roy, William Wood
  • Classification of patients having diffuse large B-cell lymphoma based upon gene expresson
    Publication number: 20070026453
    Abstract: Methods and kits for classifying patients having diffuse large B-cell lymphoma (DLBCL) based upon expression of a plurality of genes are disclosed. Real-time quantitative RT-PCR can be used to measure expression values. Correlating expression values of the plurality of genes in a tumor sample from the patient to reference expression values obtained from DLBCL patients can stratify patients in the classification groups. The methods and kits can be used to predict overall patient survival.
    Type: Application
    Filed: October 3, 2006
    Publication date: February 1, 2007
    Inventors: Ronald Levy, Mark Wechser, Izidore Lossos, Robert Tibshirani, Ash Alizadeh, David Botstein
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7166282
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: January 23, 2007
    Assignee: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Margaret Ann Roy, Colin K. Watanabe, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7157247
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: January 2, 2007
    Assignee: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Margaret Ann Roy, Colin K. Watanabe, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060275864
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: October 20, 2004
    Publication date: December 7, 2006
    Applicant: GENENTECH, INC.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Jennie Mather, James Pan, Nicholas Paoni, Margaret Roy, Timothy Stewart, Daniel Tumas, P. Williams, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060246540
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: September 29, 2005
    Publication date: November 2, 2006
    Inventors: Avi Ashkenazi, Kevin Baker, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, Austin Gurney, Ivar Kljavin, Jennie Mather, Mary Napier, James Pan, Nicholas Paoni, Margaret Roy, Timothy Stewart, Daniel Tumas, Colin Watanabe, P. Williams, William Wood, Zemin Zhang