Abstract: B-cell maturation antigen (BCMA) is expressed on malignant plasma cells. The present invention provides BCMA-specific chimeric antigen receptors and cells expressing such chimeric antigen receptors. In certain embodiments, engineered cells expressing the chimeric antigen receptors of the present invention are capable of inhibiting the growth of tumors expressing BCMA. The engineered cells of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced BCMA-targeted immune response is desired and/or therapeutically beneficial. For example, engineered cells expressing the BCMA-specific chimeric antigen receptors of the invention are useful for the treatment of various cancers, including multiple myeloma.

Abstract: B-cell maturation antigen (BCMA) is expressed on malignant plasma cells. The present invention provides BCMA-specific chimeric antigen receptors and cells expressing such chimeric antigen receptors. In certain embodiments, engineered cells expressing the chimeric antigen receptors of the present invention are capable of inhibiting the growth of tumors expressing BCMA. The engineered cells of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced BCMA-targeted immune response is desired and/or therapeutically beneficial. For example, engineered cells expressing the BCMA-specific chimeric antigen receptors of the invention are useful for the treatment of various cancers, including multiple myeloma.

Abstract: A hurdle with a riser assembly having a gate board attached to movable gate tubes that telescope upon uprights and with a cross support between the trailing ends of the legs has a height adjustment system that includes a pedal in the cross support. Depressing the pedal retracts spring loaded posts to allow a user to hold and move the gate board up or down with the hands.

Abstract: Methods and apparatus for estimating properties of a mixture of two or more surfactant species are provided. Multiple molecular dynamics simulations of the mixture are performed, each simulation using a particular total concentration of the surfactant species and a particular ratio of the surfactant species, such that the multiple simulations cover a plurality of such total concentrations and a plurality of such ratios, each simulation being carried out above the critical micelle concentration of the simulated mixture. For each simulation, and from the results of each simulation, a distribution of each surfactant species between at least a micellar pseudo-phase and a non-micellar pseudo-phase of the mixture at the particular total concentration and particular ratio for that simulation is determined.

Abstract: A security document, along with its methods of formation, is provided. The security document may include a base sheet, a colored coating on the base sheet, a foil laminate on at least a portion of the colored coating, and an outer lacquer coating over the colored coating such that the foil laminate is embedded between the colored coating and the outer lacquer coating. The outer lacquer coating may include a polymeric resin, and may also include a crosslinking agent and a wetting agent.

Abstract: A method and system for the issuance of Instant Credit has an Instant Credit engine that performs instantaneous analyses. The method and system can operate along side existing “batch” processes. In addition, the method and system offer various channels of distribution for the Instant Credit products. With the present invention, Instant Credit and other Instant services (e.g., instant account balance transfers, etc.) can be obtained via, Internet, point-of-sale and other distribution channels. The present system also enables highly dynamic product offerings, which can be generated “instantaneously” based on a variety of factors, such as, for example, the channels of distribution (e.g., telephone or Internet), the product sought and/or even the particular individual and/or entity that is applying for a line of credit.

Abstract: A security document, along with its methods of formation, is provided. The security document may include a base sheet, a colored coating on the base sheet, a foil laminate on at least a portion of the colored coating, and an outer lacquer coating over the colored coating such that the foil laminate is embedded between the colored coating and the outer lacquer coating. The outer lacquer coating may include a polymeric resin, and may also include a crosslinking agent and a wetting agent.

Abstract: The invention provides an ostomy bag assembly comprising outer (2) and inner (4) bags secured to one side of an adhesive flange (6); the adhesive flange (6) having means defining an orifice to enable bodily waste from a stomal opening to be received by the inner bag; wherein the adhesive flange is of laminar construction and comprises, in sequence, from a body-contacting surface outwards: (a) a bioadhesive layer (10) for securing the flange to a body surface of a patient about the stomal opening; (b) a first polymeric support layer (8) attached to the bioadhesive layer (a); (c) a heat sealable layer (16) having a heat sealable adhesive surface which releasably bonds the heat sealable layer to the first polymeric support surface; (d) a second polymeric support layer (14) bonded to the heat sealable layer; (e) a weldable polymeric layer (18) to which the inner and outer bags are attached, the weldable polymeric layer being bonded to the second polymeric support layer; the adhesive flange having an annular cha

Abstract: Described here is an integrated control system for crash-rated barriers and bollards, barrier products and software which will improve the operational safety characteristics of the barriers and ancillary equipment; identify potential security breaches of the barrier operating system, and predict potential failures in the system. Crash rated barriers and bollards are used to prevent a vehicle attempting to penetrate the secure perimeter of a facility with malicious intent. Installation and operation of crash rated barriers is utilized to protect both government, commercial and private facilities against such threats. Simultaneously it allows ingress and egress to the facility resulting in the end user having to determine tradeoffs for security versus safety. The barriers described here are designed and certified to withstand attacks from heavy vehicles traveling at high rates of speed.

Abstract: Multi-compartment insulated container systems and methods of using the same are described. In one embodiment, a container system includes a frame. The frame may include perimeter walls and interior walls interconnecting the perimeter walls, thereby forming a plurality of container sections having openings. At least one interior wall may be configured to facilitate heat transfer between neighboring container sections via heat conducting material. The system may include a plurality of access hatches covering at least some of the openings. The plurality of access hatches may be configured to retard heat transfer between the exterior of the frame and the interior via heat insulating material. In some embodiments, the frame may be configured to be housed within an exterior container. The exterior container may be thermally insulated.

Abstract: A method and system for the issuance of Instant Credit has an Instant Credit engine that performs instantaneous analyses. The method and system can operate along side existing “batch” processes. In addition, the method and system offer various channels of distribution for the Instant Credit products. With the present invention, Instant Credit and other Instant services (e.g., instant account balance transfers, etc.) can be obtained via, Internet, point-of-sale and other distribution channels. The present system also enables highly dynamic product offerings, which can be generated “instantaneously” based on a variety of factors, such as, for example, the channels of distribution (e.g., telephone or Internet), the product sought and/or even the particular individual and/or entity that is applying for a line of credit.

Abstract: Described here is an integrated control system for crash-rated barriers and bollards, barrier products and software which will improve the operational safety characteristics of the barriers and ancillary equipment; identify potential security breaches of the barrier operating system, and predict potential failures in the system. Crash rated barriers and bollards are used to prevent a vehicle attempting to penetrate the secure perimeter of a facility with malicious intent. Installation and operation of crash rated barriers is utilized to protect both government, commercial and private facilities against such threats. Simultaneously it allows ingress and egress to the facility resulting in the end user having to determine tradeoffs for security versus safety. The barriers described here are designed and certified to withstand attacks from heavy vehicles traveling at high rates of speed.

Abstract: A method and system for the issuance of Instant Credit has an Instant Credit engine that performs instantaneous analysis. The method and system can operate along side existing “batch” processes. In addition, the method and system offer various channels of distribution for the Instant Credit products. With the present invention, Instant Credit and other Instant services (e.g., instant account balance transfers, etc.) can be obtained via, Internet, point-of-sale and other distribution channels. The present system also enables highly dynamic product offerings, which can be generated “instantaneously” based on a variety of factors, such as, for example, the channels of distribution (e.g., telephone or Internet), the product sought and/or even the particular individual and/or entity that is applying for a line of credit.

Abstract: A security document comprising a printed security feature having a tactile feel, said security feature comprising a printed layer with particles protruding at least 10 ?m therefrom in an amount of at least 3 particles per mm2 of said layer.

Abstract: A method and apparatus for providing improved electromagnetic compatibility between a power source (20) and a switching element (22) in a switched mode power supply includes a device (24) for measuring an electrical variable, for example current, that fluctuates as the switching element (22) switches power received from the power source (20). A signal injector (28) is arranged to generate an electrical signal, for example current, of substantially the same amplitude, but opposite polarity, as the measured current, and to inject it between the power source (20) and the switching element (22) so as to tend to minimize fluctuations in the electrical variable.

Abstract: This invention relates to a printing-writing sheet comprising a medium for which at least one face has a surface on which at least one type of dry erasable marking can be made, the said surface being formed by a composition comprising a film-forming agent and a release agent not containing any coating pigments. It also relates to a reusable article comprising at least the said sheet.

Abstract: The additives, in particulate solid form, are conveyed pneumatically in a divergent stream from a pneumatic gun to impinge upon the molten iron and mix therewith. The gun is spaced above a surface of molten iron such that the pneumatically conveyed stream including the additive has a central axis which is either horizontal (or at an acute angle to the horizontal). The gun is prefereably adjustable for adjustment of the stream angle, and the stream may be either added to pouring metal or to cover a surface of the molten iron.