Abstract: The present disclosure provides methods for treating, preventing, ameliorates, inhibits, or delaying the onset of Leigh syndrome as well as methods for ameliorating, inhibiting, ameliorates, inhibits, or delaying the onset of its associated signs and/or symptoms, such as exercise-induced acid acidosis, and increases in plasma levels of growth factor 15 (GDF-15) and/or fibroblast growth factor (FGF-21) in a subject in need thereof comprising administering to the subject various compounds, mixtures of compounds or compositions, formulations or medicaments derived therefrom.

Abstract: The disclosures herein relate to novel compounds of Formula (1a): and salts thereof, wherein W, Z, L, R1 and R2 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with CGRP receptors.

Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: Aspects of the present disclosure relate to an electric or hybrid vehicle. Aspects of the vehicle may be used to provide a variety of functionality, including power exporting and aggregation, power take off functionality, thermal signature reduction, and improved vehicle longevity, vehicle turning, and vehicle control techniques.

Abstract: Rechargeable electrochemical battery cells are disclosed. In particular, are disclosed discharge state assembled rechargeable electrochemical cells, which, when in discharged state, comprises an electrically conductive anodic current collector and a cathode that comprises metallic material as an active material.

Abstract: An electrode pad for electro-stimulation includes a first non-conductive flexible substrate, a primer, and a layer of conductive silicone. The first non-conductive flexible substrate includes at least one conductive track disposed on a first side of the first non-conductive flexible substrate. The primer is disposed on the first side of the first non-conductive flexible substrate in areas not covered by the at least one conductive track. The layer of conductive silicone is disposed over the at least one conductive track and the primer. The primer is bonding the first non-conductive flexible substrate to the layer of conductive silicone providing mechanical contact between the at least one conductive track and a first side of the layer of conductive silicone.

Abstract: Certain aspects pertain to a combination sensor comprising a set of physical sensors facing different directions proximate a structure, and configured to measure solar radiation in different directions. The combination sensor also comprises a virtual facade-aligned sensor configured to determine a combi-sensor value at a facade of the structure based on solar radiation readings from the set of physical sensors.

Abstract: Provided herein is a ribonucleic acid (RNA) encoding a spike (S) protein or an immunogenic fragment thereof of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) comprising at least one non-naturally occurring amino acid mutation. In some embodiments, the S protein is derived from an Omicron variant. Additionally provided are relevant polynucleotides, vectors, cells, compositions, kits, production methods and methods of use.

Abstract: Provided herein is a ribonucleic acid (RNA) encoding a spike (S) protein or an immunogenic fragment thereof of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) comprising at least one non-naturally occurring amino acid mutation. In some embodiments, the S protein is derived from a delta variant. Additionally provided are relevant polynucleotides, vectors, cells, compositions, kits, production methods and methods of use.

Abstract: A force absorbing device for a footwear appliance includes a shoe upper and a shoe sole having a planar sole surface, such that forces between the shoe upper and planar sole surface in ground contact are absorbed by storage and controlled release of kinetic energy in an elastic or resilient field. A footwear article such as a shoe or boot includes a split-sole system that redefines a shoe sole as coplanar surfaces having a force mitigating interface for receiving sudden forces and effectively mitigating these forces by storing kinetic energy and releasing it over time. An elastic field in the force mitigation interface is defined by a resilient material adapted to deform in response to the received force. Frictional engagement between the upper and lower sole may also be augmented by surface characteristics such as dimples, voids and lubricants, in addition to interference engagement with an elastic field.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: The invention relates to renewable hydrocarbons, and more particularly to biomass-based diesel fuel produced in a process including hydrodeoxygenation (HDO) of phenolic lipids. The process may generally include combining a phenolic lipid and a hydrocarbon diluent to provide a hydrocarbon-diluted phenolic lipid then subjecting the hydrocarbon-diluted phenolic lipid to hydrodeoxygenation in a reactor to provide a reactor effluent including a hydrodeoxygenated phenolic lipid. The hydrodeoxygenated phenolic lipid is separated from the reactor effluent.

Abstract: One embodiment provides an apparatus for displaying an image comprising: a first optical substrate comprising at least one waveguide layer configured to propagate light in a first direction, wherein the at least one waveguide layer of the first optical substrate comprises at least one grating lamina configured to extract the light from the first substrate along the first direction; and a second optical substrate comprising at least one waveguide layer configured to propagate the light in a second direction, wherein the at least one waveguide layer of the second optical substrate comprises at least one grating lamina configured to extract light from the second substrate along the second direction; wherein the at least one grating lamina of at least one of the first and second optical substrates comprises an SBG in a passive mode.

Abstract: Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR inhibitors, one or more solvents, one or more gelling agents, and one or more antioxidants. Also disclosed herein are methods to treat skin disorders using such compositions.

Abstract: In order to prevent relative movement between two shipping containers located in two adjacent columns of a stack of containers on a cargo ship and separated by a gap, a compression guide is placed at least partially in the gap. The compression guide includes a spacer, one or more attachment mechanisms suitable for partial insertion into a hole in a casting of a container or flat rack, and an interface. The spacer or the interface are preferably shaped to provide two adjacent contact surfaces angled at a lead-in angle so that one of the two adjacent contact surfaces can be used to adjust placement of the compression guide or one of the two shipping containers. Optionally, the width of the spacer can be adjusted, either remotely or manually.

Abstract: Embodiments described herein may be related to apparatuses, processes, and techniques related to packages that include CPUs and PICs electrically coupled via an interconnect bridge. In embodiments, the PIC are electrically coupled with the EMIB using a fan out RDL to extend reach of the PIC electrical connectors. EICs may be electrically coupled between the PIC and the interconnect bridge. The CPUs may be CPUS, graphical processing units (GPUs), field programmable gate arrays (FPGAs), or other processors. Other embodiments may be described and/or claimed.

Abstract: A method of discovering relationships between iris physiology and cognitive states and/or emotional states of a subject includes providing a computing device and a video camera to record a close-up view of the subject's eye. A first light is held to the lower eyelid skin and a second light a distance away illuminating the stroma of the eye. The first and second light are electronically synced together and configured to flash alternatively. The user engages in a plurality of tasks while recording ocular information which is processed to identify correlations between the responses in the iris musculature and the distortions in the stroma through the use optimized algorithms. One can then identifying at least one predictive distortion is identified in the stroma capturable solely with a visible-spectrum camera correlating to a predicted responses in the iris musculature.

Abstract: A method in a reconfigurable computing system includes connecting a plurality of tensor consumers to their corresponding tensor producers via skip-buffers, which generates a plurality of skip-buffers. The method includes determining that at least one skip-buffer of the plurality of skip-buffers corresponding to a first set of tensor consumers and at least one skip-buffer of the plurality of skip-buffers corresponding to a second set of tensor consumers, are compatible to wholly or partially merge. The method also includes merging, wholly or partially, the compatible skip-buffers to produce a merged skip-buffer having a minimal buffer depth. The described method may reduce memory unit consumption and latency.

Abstract: Systems and methods are provided, which relate to identification, troubleshooting, and maintenance/repair of water systems and water devices within such systems. A given water device may include an identifier which may be captured by an installation device when attempting to install the water device and sent to a remote server. The remote server may identify the water device and provide installation support, registration, and/or configuration of the water device. Configuration of the water device may be performed based on configurations of other highly-performing water devices that are similar to the water device, as identified by the server. Problem signatures associated with known possible problems that may arise within a water device may be generated and stored in memory, then may be referenced against real-time device operation data and/or configuration data of the water device in order to diagnose and recommend remediation of problems with the water device.