Patents by Inventor David A. Bullough

David A. Bullough has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR INCREASING SMN EXPRESSION
    Publication number: 20180312839
    Abstract: Aspects of the disclosure provide compositions or compounds for activating or enhancing expression of SMN. Further aspects provide compositions and kits, e.g., comprising single stranded oligonucleotides, for activating or enhancing expression of SMN that comprises exon 7. Methods for modulating expression of SMN are also provided.
    Type: Application
    Filed: October 26, 2016
    Publication date: November 1, 2018
    Applicant: Translate Bio MA, Inc.
    Inventors: Balkrishen Bhat, David Bullough
  • Adenosine kinase inhibitors
    Patent number: 5864033
    Abstract: Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various conditions which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: January 26, 1999
    Assignee: Metabasis Therapeutics, Inc.
    Inventors: Clinton E. Browne, Bheemarao G. Ugarkar, Kevin M. Mullane, Harry E. Gruber, David A. Bullough, Mark D. Erion, Angelo Castellino
  • AICA riboside analogs
    Patent number: 5777100
    Abstract: Analogs of 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide (AICA riboside) are provided which are useful in increasing extracellular levels of adenosine.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 7, 1998
    Assignee: Gensia Inc.
    Inventors: David A. Bullough, Harry E. Gruber, Ernest K. Metzker, Kevin M. Mullane, Bheemarao G. Ugarkar, Clinton E. Browne
  • Methods for treating adenosine kinase related conditions
    Patent number: 5646128
    Abstract: Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various inflammatory conditions, including arthritis and SIRS, which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: July 8, 1997
    Assignee: Gensia, Inc.
    Inventors: Gary S. Firestein, Bheemarao G. Ugarkar, Leonard P. Miller, Harry E. Gruber, David A. Bullough, Mark D. Erion, Angelo J. Castellino, Clinton E. Browne