Patents by Inventor David A. BUSE
David A. BUSE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10464360Abstract: A printing module configured to print a label on a curved surface of an article includes an expandable printing mechanism configured to be expanded to an open configuration for receiving the article or contracted to a closed configuration placing the curved surface in an operative position with respect to a print head and an article moving assembly configured to grasp and hold the article and effect relative movement between the curved surface and the print head. The printing mechanism includes contact elements, such as rollers, that contact or otherwise engage the article when the printing mechanism is in the closed configuration and maintain the curved surface in the operative position with respect to the print head during relative movement between the curved surface and the print head.Type: GrantFiled: August 4, 2017Date of Patent: November 5, 2019Assignee: Gen-Probe IncorporatedInventors: Rolf Silbert, Robert Rosati, David Buse, Olev Tammer, Matthias Merten
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Publication number: 20190284612Abstract: An automated method for analyzing a plurality of samples within a housing of a self-contained system. The system is loaded with a plurality of samples, after which a first assay is performed on a first sample subset and a second assay performed on a second sample subset. The two assays include exposing the samples to a target capture reagent having a solid support for directly or indirectly immobilizing a target nucleic acid that may be present in one or more of the samples. The two assays may be performed with the same or different target capture reagents and target nucleic acids, but the receptacles for performing the exposing step have substantially identical geometries. Following the exposing step, an amplification reaction for amplifying a region of the target nucleic acid is performed with each sample. The amplification reactions of the two assays are performed in receptacles having different geometries.Type: ApplicationFiled: March 25, 2019Publication date: September 19, 2019Applicant: Gen-Probe IncorporatedInventors: David A. BUSE, David Opalsky, Jason F. Rhubottom, Norbert D. Hagen, Jennifer L. Tidd
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Publication number: 20190284614Abstract: A thermally conductive receptacle holder includes a plurality of wells that each receive a receptacle. A cross-brace is mounted to a support to exert a force onto an outer surface of a compressive housing such that the compressive housing exerts a force onto the receptacle holder. An optical fiber associated with each well provides optical communication between the receptacle well and an excitation signal source and/or an emission signal detector.Type: ApplicationFiled: June 7, 2019Publication date: September 19, 2019Applicant: Gen-Probe IncorporatedInventors: David BUSE, David Howard Combs, Norbert D. Hagen, David Opalsky, Bruce Richardson, Anita Prasad, Keith Moravick, Tyler Moore
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Publication number: 20180298426Abstract: A processing module is configured to extend the capabilities of an analyzer configured to process substances within each of a plurality of receptacles. The module includes a container transport configured to transport a container from a location within the processing module to a location within the analyzer that is accessible to a substance transfer device of the analyzer. A receptacle distribution system is configured to receive a receptacle from the analyzer, transfer the receptacle into the processing module, and to move the receptacle between different locations within the analyzer. A substance transfer device of the module is configured to dispense substances into or remove substances from the receptacle within the processing module. A reagent card exchanger provides an input device for inserting reagent cards into and removing reagent cards from the module, stores reagent cards within the module, and transfers reagent cards to different location within the module.Type: ApplicationFiled: June 18, 2018Publication date: October 18, 2018Inventors: David A. BUSE, David OPALSKY, Jason F. RHUBOTTOM, Norbert D. HAGEN, Jennifer L. TIDD
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Publication number: 20180298427Abstract: One or more temperature cycles are applied to the contents of a processing vial closed by an interlocked cap within a thermal cycler. The processing vial and the interlocked cap are transferred from the thermal cycler to a storage compartment within the instrument with a transfer mechanism with a probe engaged with the cap. In the storage compartment, the processing vial and interlocked cap are moved to an access opening in the instrument and are removed from the instrument through the access opening.Type: ApplicationFiled: June 22, 2018Publication date: October 18, 2018Applicant: Gen-Probe IncorporatedInventors: David A. BUSE, David Opalsky, Jason F. Rhubottom, Norbert D. Hagen, Jennifer L. Tidd
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Publication number: 20180282788Abstract: A fluid container holder includes a body having a receptacle configured to receive a container. The body has a conductive outer surface for connection to an electrical ground or voltage source, and the holder is not formed solely of an electrically conductive metal. A fluid container handling assembly includes a drawer having a holder supporting a fluid container, and a frame supporting the holder. The frame is movable between a first position providing access to the holder and a second position positioning the holder within the instrument. The assembly also includes a first lock securing the holder to the frame when the frame is at the first frame position and unlocking the holder from the frame when the frame is at the second frame position. The assembly also includes a holder transporter configured to move the holder between a first holder position and a second holder position within the instrument.Type: ApplicationFiled: March 23, 2018Publication date: October 4, 2018Inventors: David OPALSKY, David BUSE, James T. TUGGLE, Alexander NAVARRO, Patrick SHEEHAN
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Publication number: 20180275028Abstract: A method for mixing fluids in containers may include performing a mixing procedure on a plurality of containers on a container support, at least a portion of the plurality of containers being differently sized. The mixing procedure may include a plurality of mixing phases, wherein in each mixing phase the container support may be subjected to a mixing motion at a single rate for a period of time of about 5 seconds or longer, and wherein the single rate for at least one mixing phase of the plurality of mixing phases may differ from the single rate for at least one other mixing phase of the plurality of mixing phases. The mixing procedure also may include at least one non-mixing phase, wherein the container support may not be subjected to the mixing motion.Type: ApplicationFiled: March 23, 2018Publication date: September 27, 2018Applicant: Gen-Probe IncorporatedInventor: David A. BUSE
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Publication number: 20180272343Abstract: A cover assembly may include a tray assembly frame, a first cover supported by the tray assembly frame, the first cover extending in a first plane and defining one or more first openings; a second cover supported by the tray assembly frame, the second cover extending in a second plane and defining one or more second openings, wherein the first and second planes are different planes, and wherein the second cover is disposed above the first cover. The cover assembly may include one or more tray holders, each tray holder being configured to hold at least one tray in an upright orientation, wherein each tray holder is moveable between an open position and a closed position, the tray holders being accessible for loading or removing the trays in the open position, and the tray holders being positioned beneath the first and second covers in the closed position.Type: ApplicationFiled: March 23, 2018Publication date: September 27, 2018Applicant: Gen-Probe IncorporatedInventor: David A. BUSE
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Publication number: 20180250970Abstract: A printing module configured to print a label on a curved surface of an article includes an expandable printing mechanism configured to be expanded to an open configuration for receiving the article or contracted to a closed configuration placing the curved surface in an operative position with respect to a print head and an article moving assembly configured to grasp and hold the article and effect relative movement between the curved surface and the print head. The printing mechanism includes contact elements, such as rollers, that contact or otherwise engage the article when the printing mechanism is in the closed configuration and maintain the curved surface in the operative position with respect to the print head during relative movement between the curved surface and the print head.Type: ApplicationFiled: May 4, 2018Publication date: September 6, 2018Applicant: Gen-Probe IncorporatedInventors: Rolf SILBERT, Robert ROSATI, David BUSE, Olev TAMMER, Matthias MERTEN
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Patent number: 10065190Abstract: System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.Type: GrantFiled: May 25, 2017Date of Patent: September 4, 2018Assignee: Gen-Probe IncorporatedInventors: David Buse, Byron J. Knight, Julian Groeli
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Publication number: 20180230517Abstract: First and second sets of receptacles containing reagents for first and second amplification reactions, respectively, are placed in first and second receptacle holders, each associated with a thermal element. The receptacles are subjected to different first and second incubation processes resulting in the first and second amplification reactions in each of the first and second sets of receptacles that contain a first or a second target nucleic acid, respectively. The presence or absence of the first or second target nucleic acid, if any, is determined for each receptacle of the first and second sets of receptacles.Type: ApplicationFiled: April 12, 2018Publication date: August 16, 2018Applicant: Gen-Probe IncorporatedInventors: David Buse, David Howard Combs, Norbert D. Hagen, David Opalsky, Bruce Richardson, Anita Prasad, Keith Moravick, Tyler Moore
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Publication number: 20180022129Abstract: A printing module configured to print a label on a curved surface of an article includes an expandable printing mechanism configured to be expanded to an open configuration for receiving the article or contracted to a closed configuration placing the curved surface in an operative position with respect to a print head and an article moving assembly configured to grasp and hold the article and effect relative movement between the curved surface and the print head. The printing mechanism includes contact elements, such as rollers, that contact or otherwise engage the article when the printing mechanism is in the closed configuration and maintain the curved surface in the operative position with respect to the print head during relative movement between the curved surface and the print head.Type: ApplicationFiled: August 4, 2017Publication date: January 25, 2018Applicant: GEN-PROBE INCORPORATEDInventors: ROLF SILBERT, ROBERT ROSATI, DAVID BUSE, OLEV TAMMER, MATTHIAS MERTEN
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Publication number: 20170335373Abstract: An automated method for analyzing a plurality of samples within a housing of a self-contained system. The system is loaded with a plurality of samples, after which a first assay is performed on a first sample subset and a second assay performed on a second sample subset. The two assays include exposing the samples to a target capture reagent having a solid support for directly or indirectly immobilizing a target nucleic acid that may be present in one or more of the samples. The two assays may be performed with the same or different target capture reagents and target nucleic acids, but the receptacles for performing the exposing step have substantially identical geometries. Following the exposing step, an amplification reaction for amplifying a region of the target nucleic acid is performed with each sample. The amplification reactions of the two assays are performed in receptacles having different geometries.Type: ApplicationFiled: August 11, 2017Publication date: November 23, 2017Inventors: David A. BUSE, David OPALSKY, Jason F. RHUBOTTOM, Norbert D. HAGEN, Jennifer L. TIDD
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Patent number: 9817011Abstract: System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.Type: GrantFiled: February 13, 2017Date of Patent: November 14, 2017Assignee: GEN-PROBE INCORPORATEDInventors: David Buse, Byron J. Knight
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Publication number: 20170259258Abstract: System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.Type: ApplicationFiled: May 25, 2017Publication date: September 14, 2017Applicant: GEN-PROBE INCORPORATEDInventors: David BUSE, Byron J. KNIGHT, Julian GROELI
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Patent number: 9732374Abstract: A diagnostic system performs a first nucleic acid amplification reaction and a second, different nucleic acid amplification reaction. The diagnostic system includes a compartment configured to store at least a first bulk reagent container comprising a first bulk reagent for performing a sample preparation process, and a second bulk reagent container comprising a second bulk reagent for performing the first reaction. The system including a compartment configured to store at least one unit-dose pack comprising a plurality of unit-dose reagents for performing the second reaction. The diagnostic system is configured to perform the sample preparation process using the first bulk reagent on each of a plurality of samples provided to the diagnostic system. The system is configured to perform the first reaction using the second bulk reagent on a first sample subset, and perform the second reaction using the plurality of first unit-dose reagents on a second sample subset.Type: GrantFiled: March 14, 2014Date of Patent: August 15, 2017Assignee: GEN-PROBE INCORPORATEDInventors: David A. Buse, David Opalsky, Jason F. Rhubottom, Norbert D. Hagen, Jennifer L. Tidd
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Patent number: 9724948Abstract: A printing module configured to print a label on a curved surface of an article includes an expandable printing mechanism configured to be expanded to an open configuration for receiving the article or contracted to a closed configuration placing the curved surface in an operative position with respect to a print head and an article moving assembly configured to grasp and hold the article and effect relative movement between the curved surface and the print head. The printing mechanism includes contact elements, such as rollers, that contact or otherwise engage the article when the printing mechanism is in the closed configuration and maintain the curved surface in the operative position with respect to the print head during relative movement between the curved surface and the print head.Type: GrantFiled: October 21, 2015Date of Patent: August 8, 2017Assignee: GEN-PROBE INCORPORATEDInventors: Rolf Silbert, Robert Rosati, David Buse, Olev Tammer, Matthias Merten
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Patent number: 9718059Abstract: System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.Type: GrantFiled: March 13, 2014Date of Patent: August 1, 2017Assignee: GEN-PROBE INCORPORATEDInventors: David Buse, Byron J. Knight, Julian Groeli
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Publication number: 20170153264Abstract: System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.Type: ApplicationFiled: February 13, 2017Publication date: June 1, 2017Applicant: GEN-PROBE INCORPORATEDInventors: David BUSE, Byron J. KNIGHT
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Patent number: D855826Type: GrantFiled: July 10, 2017Date of Patent: August 6, 2019Assignee: Gen-Probe IncorporatedInventor: David A. Buse