Patents by Inventor David A. Canner

David A. Canner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for modified dendrimer nanoparticle delivery
    Patent number: 12419940
    Abstract: Compositions and methods for modified dendrimer nanoparticle (“MDNP”) delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to deliver two or more different repRNAs to modify expression kinetics of encoded antigens and to simultaneous deliver repRNAs and mRNAs including the same UTR elements that promote expression of encoded antigens.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: September 23, 2025
    Assignees: Massachusetts Institute of Technology, Whitehead Institute For Biomedical Research
    Inventors: Omar F. Khan, Jasdave S. Chahal, Daniel G. Anderson, Hidde Ploegh, Robert S. Langer, Tyler E. Jacks, David A. Canner
  • COMPOSITIONS AND METHODS FOR MODIFIED DENDRIMER NANOPARTICLE DELIVERY
    Publication number: 20210338789
    Abstract: Compositions and methods for modified dendrimer nanoparticle (“MDNP”) delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to deliver two or more different repRNAs to modify expression kinetics of encoded antigens and to simultaneous deliver repRNAs and mRNAs including the same UTR elements that promote expression of encoded antigens.
    Type: Application
    Filed: March 10, 2021
    Publication date: November 4, 2021
    Inventors: Omar F. Khan, Jasdave S. Chahal, Daniel G. Anderson, Hidde Ploegh, Robert S. Langer, Tyler E. Jacks, David A. Canner
  • COMPOSITIONS AND METHODS FOR MODIFIED DENDRIMER NANOPARTICLE DELIVERY
    Publication number: 20200155660
    Abstract: Compositions and methods for modified dendrimer nanoparticle (“MDNP”) delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to deliver two or more different repRNAs to modify expression kinetics of encoded antigens and to simultaneous deliver repRNAs and mRNAs including the same UTR elements that promote expression of encoded antigens.
    Type: Application
    Filed: November 22, 2019
    Publication date: May 21, 2020
    Inventors: Omar F. Khan, Jasdave S. Chahal, Daniel G. Anderson, Hidde Ploegh, Robert S. Langer, Tyler E. Jacks, David A. Canner
  • Compositions and methods for modified dendrimer nanoparticle delivery
    Patent number: 10548959
    Abstract: Compositions and methods for modified dendrimer nanoparticle (“MDNP”) delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to deliver two or more different repRNAs to modify expression kinetics of encoded antigens and to simultaneous deliver repRNAs and mRNAs including the same UTR elements that promote expression of encoded antigens.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: February 4, 2020
    Assignees: Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research
    Inventors: Omar F. Khan, Jasdave S. Chahal, Daniel G. Anderson, Hidde Ploegh, Robert S. Langer, Tyler E. Jacks, David A. Canner