Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with at least two bispecific T cell engagers each comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on an immune cell of interest, such as a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell activator comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: In a three-dimensional printing method example, a liquid functional agent is selectively applied. The liquid functional agent includes an alloying agent. A metallic build material is applied. The liquid functional agent is selectively applied before the metallic build material, after the metallic build material, or both before and after the metallic build material. The liquid functional agent patterns the metallic build material to form a composite layer. At least some of the metallic build material is exposed to energy to melt the at least some of the metallic build material to form a layer. Upon contact or after energy exposure, the alloying agent and the build material alter a composition of the composite layer.

Abstract: An electronic device applies a frequency offset function to a first signal having a first frequency. The device includes a delay element configured to output a second signal corresponding to the first signal delayed by a duration equal to a first period of said signal divided by four. A circuit branch includes a first circuit configured to divide the frequency of the first signal by a given number coupled in series with a second circuit configured to implement an integration. The circuit branch outputs a third signal and a fourth signal. A single side band mixing circuit processes the first signal, second signal, third signal and fourth signal to generate an output signal.

Abstract: In one example, a processor readable medium having instructions thereon that when executed cause an additive manufacturing machine to vary operating characteristics of a fusing laser beam at multiple different voxel locations in a layer of build material according to an energy dosage to be applied at each voxel location in an object slice, including multiple different energy dosages for corresponding multiple different voxel locations in the slice.

Abstract: An apparatus is disclosed to create a breakaway junction for 3D printed parts. Powder is spread along a target zone, such as a build bed. A liquid functional agent is selectively dispensed upon the powder to form a 3D object, a supporting part, and the breakaway junction between them.

Abstract: According to examples, an apparatus may include a processor and a memory on which are stored machine-readable instructions that when executed by the processor, cause the processor to determine physical characteristics of a build layer of build material particles. The instructions may also cause the processor to determine an adjustment to forming data based on the determined physical characteristics, the forming data to be used informing a subsequent build layer. The instructions may further cause the processor to apply the determined adjustment to the forming data for use in forming the subsequent build layer, in which portions of a three-dimensional (3D) object are to be formed in the build layer and the subsequent build layer.

Abstract: According to examples, an apparatus may include an agent delivery device to deliver a coalescing agent to selected locations of a build material layer and a plurality of microwave energy emitters, each of the microwave energy emitters including a tip to generate a focused microwave energy field onto a respective area near the tip, in which the tip is to be positioned to place a portion of the build material layer within the focused microwave energy field. The apparatus may also include a controller that may control the microwave energy emitters to direct microwave energy onto the build material layer.

Abstract: In some examples, a controller receives measurement data responsive to operation of a vibrated spreader for use in dispensing a build material onto a target surface, and controls a frequency of a vibration of the spreader based on the measurement data.

Abstract: An example sinter system includes a sinter gas inlet at a sinter furnace for a sinter gas, a tracer gas inlet at the sinter furnace for a tracer gas different from the sinter gas, and an outlet at the sinter furnace to output the sinter gas and the tracer gas. The example sinter system further includes: a support structure to support a sample green object in the sinter furnace, an opening at the support structure connected to the tracer gas inlet, the opening to output the tracer gas into the sinter furnace, and a detector to: determine an amount of the tracer gas flowing through the outlet during a sinter process as a sample green object positioned on the support structure changes shape during the sinter process with respect to the opening and modifies a flow rate of the tracer gas to the outlet; and determine when to stop the sinter process based on a determined amount of the tracer gas.

Abstract: In an example implementation, a sintering system includes a support structure in a sintering furnace to support a token green object during a sintering process. The system includes wires installed into the furnace and through the support structure to contact the object. An impedance meter is operatively coupled to the wires to determine electrical impedance of the object during the sintering process.

Abstract: In an example implementation, a sintering system includes a detection gas line to enable gas to flow into a sintering furnace from an external gas supply. The system includes a detection gas port inside the furnace through which gas from the detection gas line is to flow into the furnace, and a registration feature inside the furnace to enable positioning of a token green object proximate the gas detection port. The system includes a gas flow monitor to detect changes in gas flow through the detection gas line when the token green object shrinks during a sintering process in the furnace.

Abstract: Printers are disclosed. An example printer includes a build controller to access metrics of a layer on a work area and to select a dosing profile from a plurality of dosing profiles to fuse the layer based on the metrics.

Abstract: A three-dimensional (3D) printing system may include a build volume, a slurry reservoir to contain a slurry of build material and liquid, and a slurry dispenser to receive the slurry from the slurry reservoir and movable in a direction across the build volume to dispense slurry across the build volume.

Abstract: Techniques for using a pin array to support a 3D printed object during sintering are disclosed. An example method includes adjusting pins of a pin array to provide support for a bottom surface of the 3D printed object, and placing the 3D printed object on the pin array. The method also includes placing the 3D printed object and pin array in a sintering oven, and heating the 3D printed object in the sintering oven to sinter the 3D printed object while being supported by the pin array.

Abstract: In example implementations, a method for extracting layers of build material into a carrier. The method includes providing a layer of build material onto a bed. Portions of the layer of build material on the bed are digitally printed with a liquid functional material (LFM). The method repeats providing the layer of build material and digitally printing without applying energy to the LFM to define a structure in layers of build material on the bed. The layers of build material are extracted into a carrier and the carrier is removed.

Abstract: In a three-dimensional printing method example, a liquid functional agent is selectively applied. The liquid functional agent includes an alloying agent. A metallic build material is applied. The liquid functional agent is selectively applied before the metallic build material, after the metallic build material, or both before and after the metallic build material. The liquid functional agent patterns the metallic build material to form a composite layer. At least some of the metallic build material is exposed to energy to melt the at least some of the metallic build material to form a layer. Upon contact or after energy exposure, the alloying agent and the build material alter a composition of the composite layer.

Abstract: In an example implementation, a sintering system includes optical fiber installed into a sintering furnace. A support structure inside the furnace is to support a token green object in a predetermined position and to hold a distal end of the fiber adjacent to the predetermined position. A light source is operably engaged at a proximal end of the fiber to transmit light through the fiber into the furnace. A light detector is operably engaged at the proximal end of the fiber to receive reflected light through the fiber that scatters off a surface of the token green object.

Abstract: In example implementations, an apparatus includes a housing, a movable base, a tab portion and a coupling mechanism. The housing is comprised of a microwave transparent material. The movable base is coupled to the housing to receive build material that is digitally printed. The tab portion is coupled to a bottom portion of at least one wall of the housing. The tab portion stops the movable base. The coupling mechanism is coupled to the housing to removably attach the apparatus to a three dimensional printer.

Abstract: In a three-dimensional printing method example, a liquid functional agent is selectively applied. The liquid functional agent includes an alloying agent. A metallic build material is applied. The liquid functional agent is selectively applied before the metallic build material, after the metallic build material, or both before and after the metallic build material. The liquid functional agent patterns the metallic build material to form a composite layer. At least some of the metallic build material is exposed to energy to melt the at least some of the metallic build material to form a layer. Upon contact or after energy exposure, the alloying agent and the build material alter a composition of the composite layer.