Abstract: Aspects relate to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: The invention provides aza-heterocyclyl carboxamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as bacterial infections, and in inhibiting LpxC activity.

Abstract: An example system for estimating a hydration level of an individual can include: a mechanism configured to apply mechanical pressure to a digit of the individual; an light detector configured to sense the light from the digit; and a controller programmed to perform functions including: send a first signal to the mechanism to apply the mechanical pressure to the digit; send a second signal to the mechanism to release the mechanical pressure on the digit; determine a capillary refill time based upon a third signal from the light detector indicating an amount of time for capillaries of the individual to refill with blood; and estimate the hydration level of the individual based upon the capillary refill time and one or more additional parameters.

Abstract: An optical coherence tomography image generation apparatus includes: an acquisition unit that acquires a stereoscopic 3D image of a target; a determination unit that determines a plurality of scan areas on the target, on the basis of the stereoscopic 3D image; and a control unit that relatively moves an irradiation position of light for capturing an optical coherence tomography image of the target with respect to the target, and that controls scanning by the light of each of the plurality of scan areas.

Abstract: Aspects relate to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: A computing platform may generate a schema to prompt for user access information, wherein the user access information includes: 1) a set of authorized users and 2) one or more portions of an information source to which the set of authorized users have access. The computing platform may send, to a first user device, the schema. The computing platform may receive, from the first user device, the user access information. The computing platform may translate the user access information to structured user information, which may include translating the user access information from a first format into a second format. The computing platform may send, to a second user device corresponding to one of the set of authorized users, the structured user information.

Abstract: Examples provide a brake pedal assembly including a pedal housing, a bracket for securement within a vehicle, and a pedal arm having a proximal portion pivotally supported by the pedal housing and a distal portion including a foot pad spaced from the bracket. The pedal arm pivots from an unactuated position to a fully actuated position in response to application of a force to the foot pad. A pedal emulator system provides variable operator feedback as the pedal arm pivots in response to the application of force. The pedal emulator system includes a first spring set engaged with the pedal arm at the unactuated position and operable to bias the pedal arm toward the unactuated position, and a second spring set engaged with the pedal arm only after the pedal arm pivots from the unactuated position to a first intercept position between the unactuated and fully actuated positions.

Abstract: Systems and methods for prescribing athletic activity to be performed by a user, and for adapting the prescribed athletic activity based on completed (e.g. ongoing) athletic performances by the user. A coaching plan may be automatically created that prescribes personalized athletic activities as a user trains towards a goal date. The athletic information may be received from one or more sensor devices associated with a user, and the coaching plan may be continuously or intermittently updated based on the received sensor data.

Abstract: An information processing apparatus includes: a detection unit that detects a target-to-target distance between an imaging target and a light irradiation unit that irradiates light for scanning the imaging target; and a scan control unit that starts irradiation with the light by the light irradiation unit in a case where the target-to-target distance is a desired distance.

Abstract: An assembly for offsite construction of a building, a connector for use in such an assembly, along with a method of manufacture of such a connector, and a method of construction using the assembly. The connector includes first and second buttress elements defining, respectively, a first location portion and a second location portion. The first location portion and the second location portion are configured, respectively, to receive first and second structural elements extending at transverse angles to each other. The first and second buttress elements each has first and second opposite side walls defining an access space between them for a connector to be accessed. The second side wall of the first buttress element and the second side wall of the second buttress element together define a third location portion configured to receive a third structural element extending transversely to the first and second structural elements.

Abstract: The present invention relates to compounds of Formula (II) that target the PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: wherein R2, R4, R6, Y1, Y2, A1, A2, A3, and A4 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PMS2 activity is implicated.

Abstract: The present invention relates to compounds of Formula (I) that target PMS2, a component of DNA Mismatch Repair (MMR): wherein R2, R4, R6, A1, A2, A4, L and Q are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PMS2 is implicated.

Abstract: In some embodiments, an electronic device performs techniques related to displaying personalized workout suggestions based on completed workouts. In some embodiments, an electronic device performs techniques related to starting an audio-based workout. In some embodiments, an electronic device performs techniques related to displaying information about a workout during playback of workout content. In some embodiments, an electronic device performs techniques related to displaying information about physical activity of a user relative to a group of users. In some embodiments, an electronic device performs techniques related to coordinating display of workout content among multiple devices.

Abstract: A method for manufacturing a semiconductor device and a semiconductor device produced thereby. For example and without limitation, various aspects of this disclosure provide a method for manufacturing a semiconductor device, and a semiconductor device produced thereby, that that comprises a transparent, translucent, non-opaque, or otherwise optically-transmissive, external surface.

Abstract: A system for including a chatbot into a group chat session is provided. The system receives a chatbot mention message from a user in the group chat session. The chatbot mention message includes a chatbot prompt for a chatbot. The system generates a prompt using the chatbot mention message and communicates the response as a chatbot response message to each user in the group chat session.

Abstract: A method at a server system for processing patient test data to provide a more automated method of inputting point of care test data into an electronic health record avoiding user intervention. Point of care test data can be automatically completed and uploaded into an electronic health record. If a point of care test order is required in an electronic health record, it can automatically be created or identified for the uploading of point of care test data to the electronic health record for association with the automatically created or identified order.

Abstract: A self-healing hydraulic seal is provided. The self-healing hydraulic seal is prepared from a water-swellable elastomeric composition comprising a base polymer and a plant-based polysaccharide.

Abstract: The present invention relates to compounds of Formula (I) that target the MLH1 or MLH1 and PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: Formula (I) wherein R6, Y1, Y2, A1, A2, A3, A4, R11, R12, R13 and R14 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which MLH1 or MLH1 and PMS2 activity is implicated.

Abstract: A chatbot system for filtering conversation content. A chatbot system receives, from a client system, a prompt of a user during an interactive session. The chatbot system filters the prompt of the user based on a set of platform policies and generates a response based on the filtering of the prompt of the user, and communicates the response to the client system.

Abstract: Methods and systems for creating a multi-applicant account profile are described. During a first remote session, a first applicant provides at least two pieces of contact data for second applicant. A unique link and a one-time password are transmitted to the second applicant using respective first and second pieces of contact data. A second remote session is initiated, in response to receipt of the one-time password, provided via the unique link. During the second remote session, identification information of the second applicant is provided. A new multi-applicant account profile is then created, after verifying the identification information of the first applicant and the second applicant.