Abstract: An intermittent flushing plunger packing assembly is described herein. The packing assembly includes a plurality of annular seals disposed about the plunger configured to reciprocate along a linear axis within the fluid bore of the pump, and an annular packing nut disposed circumferentially about the plunger and configured to retain the plurality of annular seals and adjust a combined height of the plurality of annular seals. A selected one of the plurality of annular seals proximate to the fluid cylinder of the pump has a flushing fluid chamber in fluid communication with a flushing fluid port coupled to a first one-way check valve allowing a pressurized flushing fluid to be introduced and retained within the flushing fluid chamber and creating a fluid barrier to prevent frac fluid in the fluid cylinder from bypassing the annular seals.

Abstract: The present invention provides compounds of Formula I?, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: Systems and methods for prescribing athletic activity to be performed by a user, and for adapting the prescribed athletic activity based on completed (e.g. ongoing) athletic performances by the user. A coaching plan may be automatically created that prescribes personalized athletic activities as a user trains towards a goal date. The athletic information may be received from one or more sensor devices associated with a user, and the coaching plan may be continuously or intermittently updated based on the received sensor data.

Abstract: An information processing apparatus includes: a detection unit that detects a target-to-target distance between an imaging target and a light irradiation unit that irradiates light for scanning the imaging target; and a scan control unit that starts irradiation with the light by the light irradiation unit in a case where the target-to-target distance is a desired distance.

Abstract: A method for monitoring an IoT network receives a first user input from a user, the first user input comprising a selection of a machine learning model associated with an activity, and a second user input from the user, the second user input comprising a selection of one or more attributes of a set of attributes associated with an asset. User created rules define an asset behavior. The rules are input by the user in a human-readable language. Information representing the asset type and asset behavior is associated with one or more physical devices associated with a node of the network. Data indicative of a current state of the asset, the current state of the asset indicative of at least one attribute of the asset, is received and processed in the machine learning model to determine whether a notification should be provided.

Abstract: A circuit for transposing a matrix comprising reversal circuitry configured, for each of one or more diagonals of the matrix, to receive elements of the matrix in a first vector and generate a second vector that includes the elements of the matrix in an order that is a reverse of an order of the elements of the matrix in the first vector, and rotation circuitry configured, for each of the one or more diagonals of the matrix, to determine a number of positions by which to rotate the elements of the matrix in the second vector, receive the second vector of elements of the matrix, and generate a third vector that includes the elements of the matrix in the second vector in an order that is a rotation of the elements of the matrix in the second vector by the determined number of positions.

Abstract: An assembly for offsite construction of a building, a connector for use in such an assembly, along with a method of manufacture of such a connector, and a method of construction using the assembly. The connector includes first and second buttress elements defining, respectively, a first location portion and a second location portion. The first location portion and the second location portion are configured, respectively, to receive first and second structural elements extending at transverse angles to each other. The first and second buttress elements each has first and second opposite side walls defining an access space between them for a connector to be accessed. The second side wall of the first buttress element and the second side wall of the second buttress element together define a third location portion configured to receive a third structural element extending transversely to the first and second structural elements.

Abstract: The present invention relates to compounds of Formula (II) that target the PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: wherein R2, R4, R6, Y1, Y2, A1, A2, A3, and A4 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PMS2 activity is implicated.

Abstract: A method includes determining one or more audio characteristics of a first digital signal representing a first portion of streaming media content provided by a media playback application to an audio output component; playing the first portion of the media content into an environment; capturing, by an audio output component, a second digital signal representing the first portion of the media content as played; determining, based on the captured second digital signal, one or more detected audio characteristics of the media content as played into the environment; determining a difference between the one or more audio characteristics of the media content and the one or more detected audio characteristics; calibrating a second portion of the media content based on the difference and based on a determination that the second portion is to be calibrated; and playing, by the audio output component into the environment, the second portion as calibrated.

Abstract: The present invention relates to compounds of Formula (I) that target PMS2, a component of DNA Mismatch Repair (MMR): wherein R2, R4, R6, A1, A2, A4, L and Q are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PMS2 is implicated.

Abstract: The present disclosure provides methods of differentiating pluripotent stem cells, including induced pluripotent stem cells, into lineage-specific floor plate midbrain progenitor cells, determined dopaminergic neuronal progenitor cells, committed dopaminergic neuronal progenitor cells and/or dopaminergic neuronal cells. Also provided are compositions uses thereof, such as for treating neurodegenerative diseases and conditions, including Parkinson's disease, and articles of manufacture and kits for use thereof.

Abstract: In some embodiments, an electronic device performs techniques related to displaying personalized workout suggestions based on completed workouts. In some embodiments, an electronic device performs techniques related to starting an audio-based workout. In some embodiments, an electronic device performs techniques related to displaying information about a workout during playback of workout content. In some embodiments, an electronic device performs techniques related to displaying information about physical activity of a user relative to a group of users. In some embodiments, an electronic device performs techniques related to coordinating display of workout content among multiple devices.

Abstract: The present disclosure provides an improved cogwheel permitting enhanced meshing of cogwheels when operating perpendicularly. Exemplary embodiments introduce a multi-cogwheel design with specific dimensions and tooth profiles to permit perpendicular engagement of cogwheels whilst permitting translation of such cogwheels.

Abstract: A method for manufacturing a semiconductor device and a semiconductor device produced thereby. For example and without limitation, various aspects of this disclosure provide a method for manufacturing a semiconductor device, and a semiconductor device produced thereby, that that comprises a transparent, translucent, non-opaque, or otherwise optically-transmissive, external surface.

Abstract: Methods and systems for facilitating group payment are disclosed. In one embodiment, a group payment system is configured to execute instructions to perform operations that include receiving, from a first computing device, a request to create a group payment event and, in response, providing to the first computing device a first interface associated with the group payment event. The operations further include receiving, from a second computing device, a request to join the group payment event and, in response, providing a second interface to the second computing device. The operations further include receiving, from the first and/or second computing devices, messages associated with the group payment event and modifying the first and second interfaces to display the messages. The operations further include receiving, from the first and/or second computing devices, financial contributions for the group payment event and modifying the first and second interfaces to display the financial contributions.

Abstract: A method for creating optical articles includes moving first and second mold portions relative to one another. This disclosure includes injection molds for reducing cycle times and related methods. Some molds include first and second mold portions movable relative to one another from open to closed positions in which each recess of the first mold portion cooperates with a respective recess of the second mold portion to define a chamber. Each chambers includes a first cooling body coupled to the first mold portion, a second cooling body coupled to the second mold portion, and first and second inserts removably coupled, respectively, to the first and second cooling bodies. The inserts cooperate to define a mold cavity within the chamber configured to receive a thermoplastic material. Each of the cooling bodies has an inlet, an outlet, and a fluid cavity in fluid communication with the inlet and the outlet.

Abstract: A system for including a chatbot into a group chat session is provided. The system receives a chatbot mention message from a user in the group chat session. The chatbot mention message includes a chatbot prompt for a chatbot. The system generates a prompt using the chatbot mention message and communicates the response as a chatbot response message to each user in the group chat session.

Abstract: A method at a server system for processing patient test data to provide a more automated method of inputting point of care test data into an electronic health record avoiding user intervention. Point of care test data can be automatically completed and uploaded into an electronic health record. If a point of care test order is required in an electronic health record, it can automatically be created or identified for the uploading of point of care test data to the electronic health record for association with the automatically created or identified order.

Abstract: Implementations set forth herein relate to an automated assistant and/or other application that can adapt settings of a foldable display interface of a computing device according to user interactions occurring during a multilingual conversation. During the multilingual conversation between at least two users, translated content of the conversation can be rendered at a portion of the display interface according to which user is actively speaking. When a user is actively speaking, a brightness level of a portion of the display interface that is facing another user in the conversation can be modified to emphasize that the user is speaking and that the translated content is being rendered. When the user who is speaking is also the owner of the computing device, a portion of the display interface that is facing the other user can exhibit a limited responsiveness to touch inputs.

Abstract: A self-healing hydraulic seal is provided. The self-healing hydraulic seal is prepared from a water-swellable elastomeric composition comprising a base polymer and a plant-based polysaccharide.