Abstract: Described in embodiments herein are thiol-ene polymeric compositions that exhibit photo-induced, reversible switching between a solid (e.g., elastomeric) state and a liquid (e.g., flowable) state. The thiol-ene polymeric compositions may comprise a vinyl oligomer comprising at least two vinyl groups, a thiol oligomer comprising at least two thiol groups, and a Type I photoinitiator. In some embodiments, the composition comprises an excess of thiol groups relative to vinyl groups (e.g., a ratio of thiol groups to vinyl groups in the composition is at least 3:1). Reversible switching between the solid state and the liquid state may be induced through exposure of the composition to electromagnetic radiation (e.g., ultraviolet (UV) radiation). In some cases, reversible switching may be induced by a relatively low amount of energy (e.g., about 1 J/cm2 or less).

Abstract: In some embodiments, a dielectric elastomer device may include at least first and second dielectric elastomer layers, and a first layer of conductive particles disposed between the first and second dielectric elastomer layers and forming a first electrode of the device, wherein portions of the second dielectric elastomer layer are directly bonded with portions of the first dielectric elastomer layer through the first layer of the conductive particles. The dielectric elastomer layer may, for example, comprise a cured acrylic elastomer precursor with an additive including urethane, polybutadiene, or silicone. Electrodes in different layers may be interconnected by infusing a liquid or semi-liquid conductive material in contact with each of a plurality of the electrodes of the actuator or sensor device, and solidifying the conductive material to form a conductive path that interconnects the plurality of electrodes.

Abstract: The invention relates to protein building block named the Self-Assembling Kelch (SAKe) protein. The protein has a stable, symmetric design with readily accessible loops that can be varied in both sequence and length to later bind larger molecules or scaffold a catalytic site.

Abstract: Using multiple overlays with a data processing array includes loading an application in a data processing array. The data processing array includes a plurality of compute tiles each having a processor. The application specifies kernels executable by the processors and implements stream channels that convey data to the plurality of compute tiles. During runtime of the application, a plurality of overlays are sequentially implemented in the data processing array. Each overlay implements a different mode of data movement in the data processing array via the stream channels. For each overlay implemented, a workload is performed by moving data to the plurality of compute tiles based on the respective mode of data movement.

Abstract: Aspects of the disclosure relate to “wet” transcatheter prosthetic heart valve or other implant packaging and assemblies in which a prosthetic heart valve or other implant is loaded into a first portion of a delivery device and positioned within a container in which sterilizing fluid is retained to sterilize interior portions of the container as well as provide moisture to prevent the implant from drying out. The disclosure also relates to methods of sterilizing the disclosed assemblies. Some disclosed methods include at least two sterilizing steps and adjustment of a mechanical seal member or formation of multiple seals so that areas proximate the seals are also sterilized during the sterilization process.

Abstract: Packaging systems and methods for wet storage and/or shipping of prosthetic heart valve or other medical devices are disclosed.

Abstract: A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.

Abstract: A device includes a data processing engine array having a plurality of data processing engines organized in a grid having a plurality of rows and a plurality of columns. Each data processing engine includes a core, a memory module including a memory and a direct memory access engine. Each data processing engine includes a stream switch connected to the core, the direct memory access engine, and the stream switch of one or more adjacent data processing engines. Each memory module includes a first memory interface directly coupled to the core in the same data processing engine and one or more second memory interfaces directly coupled to the core of each of the one or more adjacent data processing engines.

Abstract: An apparatus includes a data processing array having a plurality of array tiles. The plurality of array tiles include a plurality of compute tiles. The compute tiles include a core coupled to a random-access memory (RAM) in a same compute tile and to a RAM of at least one other compute tile. The data processing array is subdivided into a plurality of partitions. Each partition includes a plurality of array tiles including at least one of the plurality of compute tiles. The apparatus includes a plurality of clock gate circuits being programmable to selectively gate a clock signal provided to a respective one of the plurality of partitions.

Abstract: Methods and apparatus for modulating light using a tunable light modulation device. The tunable light modulation devices comprises an elastomer structure including at least one elastomer layer, a compliant electrode network of conducting fibers arranged on a first surface of the at least one elastomer layer, a patterned electric conductor arranged on a second surface of the at least one elastomer layer opposite the first surface. The patterned electric conductor includes a plurality of individually-addressable sections, and the compliant electrode network is configured to compress the at least one elastomer layer in the presence of an electric field between the compliant electrode network and one or more of the individually-addressable sections of the patterned electric conductor to produce a voltage-dependent roughening of the at least one elastomer layer.

Abstract: Aspects of the disclosure relate to “wet” transcatheter prosthetic heart valve or other implant packaging and assemblies in which a prosthetic heart valve or other implant is loaded into a first portion of a delivery device and positioned within a container in which sterilizing fluid is retained to sterilize interior portions of the container as well as provide moisture to prevent the implant from drying out. The disclosure also relates to methods of sterilizing the disclosed assemblies. Some disclosed methods include at least two sterilizing steps and adjustment of a mechanical seal member or formation of multiple seals so that areas proximate the seals are also sterilized during the sterilization process.

Abstract: An apparatus includes a data processing array having a plurality of array tiles. Each array tile can include a random-access memory (RAM) having a local memory interface accessible by circuitry within the array tile and an adjacent memory interface accessible by circuitry disposed within an adjacent array tile. Each adjacent memory interface of each array tile can include isolation logic that is programmable to allow the circuitry disposed within the adjacent array tile to access the RAM or prevent the circuitry disposed within the adjacent array tile from accessing the RAM. The data processing array can be subdivided into a plurality of partitions wherein the isolation logic of the adjacent memory interfaces is programmed to prevent array tiles from accessing RAMs across a boundary between the plurality of partitions.

Abstract: An apparatus includes a data processing array having a plurality of array tiles. Each array tile can include a random-access memory (RAM) having a local memory interface accessible by circuitry within the array tile and an adjacent memory interface accessible by circuitry disposed within an adjacent array tile. Each adjacent memory interface of each array tile can include isolation logic that is programmable to allow the circuitry disposed within the adjacent array tile to access the RAM or prevent the circuitry disposed within the adjacent array tile from accessing the RAM. The data processing array can be subdivided into a plurality of partitions wherein the isolation logic of the adjacent memory interfaces is programmed to prevent array tiles from accessing RAMs across a boundary between the plurality of partitions.

Abstract: Examples herein describe techniques for communicating between data processing engines in an array of data processing engines. In one embodiment, the array is a 2D array where each of the DPEs includes one or more cores. In addition to the cores, the data processing engines can include streaming interconnects which transmit streaming data using two different modes: circuit switching and packet switching. Circuit switching establishes reserved point-to-point communication paths between endpoints in the interconnect which routes data in a deterministic manner. Packet switching, in contrast, transmits streaming data that includes headers for routing data within the interconnect in a non-deterministic manner. In one embodiment, the streaming interconnects can have one or more ports configured to perform circuit switching and one or more ports configured to perform packet switching.

Abstract: A flexible, sterilizable pouch includes a first gas-impermeable web, a second gas-permeable web, and the third gas-impermeable web. The webs are arranged and sealed to form a cavity portion of the pouch and a header portion of the pouch. The header portion of the pouch is gas-permeable through the second gas-permeable web. The cavity portion of the pouch is configured to hold a medical device for sterilization and is configured to be sealed from the header portion after sterilization, thereby making the cavity portion gas-impermeable. The header is also configured to be removed from the pouch, leaving the cavity portion.

Abstract: The present invention relates to the use of receptor tyrosine kinase (RTK) oligomers as markers of RTK activation and signalling. Methods are described based upon determining the presence of RTK oligomers and/or determining the nanometre spatial separation between RTK molecules assembled as RTK oligomers at the cell surface. Such methods are directed to the monitoring of RTK activation in cells and the detection of mutations in RTKs. Methods are also described for determining prognosis for subjects having diseases characterised by aberrant RTK activation and for selecting subjects for treatment with RTK inhibitors.

Abstract: Examples herein describe performing non-sequential DMA read and writes. Rather than storing data sequentially, a DMA engine can write data into memory using non-sequential memory addresses. A data processing engine (DPE) controller can submit a first job using first parameters that instruct the DMA engine to store data using a first non-sequential write pattern. The DPE controller can also submit a second job using second parameters that instruct the DMA engine to store data using a second, different non-sequential write pattern. In this manner, the DMA engine can switch to performing DMA writes using different non-sequential patterns. Similarly, the DMA engine can use non-sequential reads to retrieve data from memory. When performing a first DMA read, the DMA engine can retrieve data from memory using a first sequential pattern and then perform a second DMA read where data is retrieved from memory using a second non-sequential read pattern.

Abstract: A device includes a data processing engine array having a plurality of data processing engines organized in a grid having a plurality of rows and a plurality of columns. Each data processing engine includes a core, a memory module including a memory and a direct memory access engine. Each data processing engine includes a stream switch connected to the core, the direct memory access engine, and the stream switch of one or more adjacent data processing engines. Each memory module includes a first memory interface directly coupled to the core in the same data processing engine and one or more second memory interfaces directly coupled to the core of each of the one or more adjacent data processing engines.

Abstract: A method of delivering and deploying a prosthetic valve includes percutaneously advancing a catheter to a treatment site, proximally retracting an outer shaft relative to an inner shaft to expose the prosthetic valve such that the prosthetic valve self-expands to a radially expanded configuration, disconnecting a tip retractor from a handle of the catheter, and proximally retracting the tip retractor to proximally retract the inner shaft and a nosecone attached to a distal end of the inner shaft relative to the outer shaft and/or the handle.