Abstract: Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with TREX1.

Abstract: A skin engaging member for a razor cartridge includes an erodible first layer and an erodible second layer below the first layer. Each layer includes a lubricious water soluble polymer and can include a water insoluble polymer. The second layer includes a fragrance that can be in the form of microcapsules or a suitable additive of the polymeric material(s). As the first layer erodes during normal use of the razor cartridge the second layer is eventually exposed dissolving or fracturing the microcapsules or otherwise releasing the fragrance. The fragrance is malodorous indicating to e.g. a vision impaired user that the optimal life of the razor cartridge is at or nearing its end. The first layer can also be provided with a non-malodorous fragrance. A third erodible layer can be provided between the first and second layer and can also include a fragrance. End-of-optimal-life indication can be rapid or gradual.

Abstract: A handle assembly and related methods of use and manufacture. According to one embodiment, the handle assembly can include a mount that is configured to be secured to an object, such as a wall of a drawer. The mount can include a spine. The spine, in turn, can include a top surface. A ramp can extend from a first side of the mount, and a handle can extend from a second side of the mount.

Abstract: A skin engaging member for a razor cartridge includes an erodible first layer and an erodible second layer below the first layer. Each layer includes a lubricious water soluble polymer and can include a water insoluble polymer. The second layer includes a fragrance that can be in the form of microcapsules or a suitable additive of the polymeric material(s). As the first layer erodes during normal use of the razor cartridge the second layer is eventually exposed dissolving or fracturing the microcapsules or otherwise releasing the fragrance. The fragrance is malodorous indicating to e.g. a vision impaired user that the optimal life of the razor cartridge is at or nearing its end. The first layer can also be provided with a non-malodorous fragrance. A third erodible layer can be provided between the first and second layer and can also include a fragrance. End-of-optimal-life indication can be rapid or gradual.

Abstract: A temporary safety railing system includes a plurality of upright support structures. Each support structure includes a base member configured for temporary attachment to a support surface, an upright member attached to the base member and a plurality of C-shaped mounting brackets rotatably attached to each upright member on the same side thereof in a longitudinally spaced relationship with an upper mounting bracket positioned proximate a top end of each upright member and a lower mounting bracket positioned a distance below the upper mounting bracket. A plurality of wood upper railing members are attached to the upper mounting brackets and lower railing members are attached to the lower mounting brackets. The upper and lower railing members span a distance between adjacent support structures.

Abstract: A replacement cartridge for a razor assembly is provided that includes a shaving aid body for use with the razor assembly. The shaving aid body includes an aperture disposed within a contact surface. The aperture is sized to receive a razor cartridge. Some embodiments of the present replacement cartridge include a base. In some of those embodiments the base includes one or more features for attaching the replacement cartridge to the razor assembly.

Abstract: The present invention relates to taste masked compositions of S-alkylisothiouronium derivatives, including, but not limited to, S-ethylisothiouronium diethylphosphate, in the form of a coated oral tablet having a desirable dissolution profile.

Abstract: A replacement cartridge for a razor assembly is provided that includes a shaving aid body for use with the razor assembly. The shaving aid body includes an aperture disposed within a contact surface. The aperture is sized to receive a razor cartridge. Some embodiments of the present replacement cartridge include a base. In some of those embodiments the base includes one or more features for attaching the replacement cartridge to the razor assembly.

Abstract: A replacement cartridge for a razor assembly is provided that includes a shaving aid body for use with the razor assembly. The shaving aid body includes an aperture disposed within a contact surface. The aperture is sized to receive a razor cartridge. Some embodiments of the present replacement cartridge include a base. In some of those embodiments the base includes one or more features for attaching the replacement cartridge to the razor assembly.

Abstract: A razor cartridge is provided that includes a frame, at least four razor blades, a guard that includes a contact surface, and a cap that includes a contact surface. The razor blades are supported by the frame. The guard is disposed forward of the razor blades and the cap is disposed aft of the razor blades. The razor blades are arranged so that the cutting edge of each razor blade is adjacent a plane that tangentially intersects the contact surfaces of the guard and the cap. As a result, each stroke of the razor exposes the surface being shaved to at least four razor blade cutting edges in succession. A unitary razor assembly that includes a head characterized in the same manner as the above-described cartridge is also provided.

Abstract: In a razor cartridge, a frame has an opening defined in part by a leading surface and a trailing surface. Positioned within the opening are a plurality of cutting edges, each cutting edge defined by a blade. In a shaving operation, a hirsute surface contacts in turn the leading surface, cutting edges, and the trailing surface. A contact plane is defined between the leading surface and the trailing surface that provides a reference for determining whether a cutting edge has a neutral, positive, or negative exposure. All of the cutting edges within the razor cartridge have an exposure relative to the contact plane that is one of all positive or all negative.

Abstract: A razor assembly is provided that includes a razor cartridge with one or more razor blades, a shaving aid body, a handle, and a linkage pivotally connected to the handle. The linkage is connected to the razor cartridge and the shaving aid body in a manner such that the razor cartridge and the shaving aid body are moveable relative to the handle. Movement of one of the razor cartridge or the shaving aid body in a first direction causes the other of the razor cartridge or the shaving aid body to move in a second direction substantially opposite the first direction. As a result, the positions of the shaving aid body and the razor cartridge are continuously adjusted to maintain the contact surface of the shaving aid body approximately co-planar with the cutting edges of the razor blades within the razor cartridge.

Abstract: A replacement cartridge container is provided that includes a tub and a selectively removable lid. The tub includes a base panel attached to a side panel. The base panel and the side panel each have an interior surface and an exterior surface. A cavity is formed contiguous with the interior surfaces of the base panel and the side panel. The selectively removable lid attaches to the tub and forms a seal with the tub.

Abstract: In a razor cartridge, a platform portion has a first cartridge section that includes at least one first pair of razor blades position therein. Each of the first pair or razor blades has an at least partially exposed cutting edge. A second cartridge section is also provided and is coupled to the platform portion. The second cartridge section includes at least one pair of second razor blades positioned therein, each of the second pair of razor blades also has an at least partially exposed cutting edge. The razor cartridge can be mounted either temporarily or permanently to a handle and the cutting edges of each of the first and second pair of razor blades face one another so that during a shaving operation, the razor cartridge can cut hair when drawn over a user's skin in either of two generally opposite directions.

Abstract: A razor assembly is provided that includes a razor cartridge with one or more razor blades, a shaving aid body, a handle, and a linkage pivotally connected to the handle. The linkage is connected to the razor cartridge and the shaving aid body in a manner such that the razor cartridge and the shaving aid body are moveable relative to the handle. Movement of one of the razor cartridge or the shaving aid body in a first direction causes the other of the razor cartridge or the shaving aid body to move in a second direction substantially opposite the first direction. As a result, the positions of the shaving aid body and the razor cartridge are continuously adjusted to maintain the contact surface of the shaving aid body approximately co-planar with the cutting edges of the razor blades within the razor cartridge.

Abstract: The present invention provides a shaving device that includes a razor cartridge and a handle. The razor cartridge includes one or more razor blades and a liquid material storage element disposed within a reservoir. A dispensing medium extends between the liquid material storage element and an outer surface of the razor cartridge. During the act of shaving, the dispensing medium operates to draw the liquid from the reservoir to a user contact end of the dispensing medium, where the liquid is the applied to the area being shaved adjacent to the cutting edge(s).

Abstract: A razor blade and support assembly is provided which flexes in response to shaving forces near slots in the blade support. A razor cartridge includes one or more of the aforementioned razor blade and support assemblies positioned in a housing. The razor cartridge may be permanently or removably coupled to a handle to provide a shaving razor.

Abstract: A razor cartridge is provided that includes a frame, at least four razor blades, a guard that includes a contact surface, and a cap that includes a contact surface. The razor blades are supported by the frame. The guard is disposed forward of the razor blades and the cap is disposed aft of the razor blades. The razor blades are arranged so that the cutting edge of each razor blade is adjacent a plane that tangentially intersects the contact surfaces of the guard and the cap. As a result, each stroke of the razor exposes the surface being shaved to at least four razor blade cutting edges in succession. A unitary razor assembly that includes a head characterized in the same manner as the above-described cartridge is also provided.

Abstract: A blade cartridge for a wet shaving device comprises a housing including a lower housing member and an upper housing member cooperating to define a cavity. First and second blade assemblies are disposed within the cavity. Each of the first and second blade assemblies includes at least one blade defining a cutting edge, wherein the cutting edge of the blade of the first blade assembly generally faces the cutting edge of the blade of the second blade assembly to permit bidirectional shaving.