Abstract: A trailer towable compact telehandler having an operator cab with an internal width greater than 700 mm and a curbside weight less than 2950 kg. Also included is a telehandler having a side-mounted engine which extends through a side wall of the chassis and under a lifting arm of the telehandler. Also included is a compact tool carrier having a reduced fore-aft dimension between an attachment plane and a principal pivot member.

Abstract: Disclosed herein are subcutaneously administered, immunogenic compositions (e.g., vaccines) and methods of using and preparing the same. In some embodiments, the immunogenic compositions generate IgG antibodies to the spike proteins of the Wuhan-Hu-1, Delta B.1.617.2, and Omicron BA.1 variants of SARS-CoV-2 and may be suitable for use in preventing an infectious disease, such as SARS-CoV-2.

Abstract: Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.

Abstract: There is provided a fan assembly comprising a motor-driven impeller arranged to generate an airflow, an air outlet arranged to emit the airflow, a plurality of sensors arranged to measure a value for each of a plurality of air quality characteristics, a display and a processor. The processor is configured to receive measured values for each of the plurality of air quality characteristics, identify one of a corresponding set of intervals within which the measured value falls and select an air quality index value associated with the identified interval. The processor is then configured to identify the highest of the selected air quality index values as a current overall air quality index value and to cause the display to display a time series plot of the current air quality index value and a number of preceding air quality index values.

Abstract: Techniques described herein are directed to analyzing intellectual-property data according to provide various intellectual property related services to organizations. In particular implementations, information related to products and/or services may be obtained from a number of data sources. Additionally, information related to intellectual-property assets, such as patents, trademarks, copyrights, trade secrets, and know-how, may be obtained. In various situations, the intellectual-property assets may be mapped to respective products and/or services. The mappings between the products and/or services and intellectual-property assets may be used to provide intellectual property related services that correspond to the intellectual-property assets, such as valuation services, strategy-related services, or risk-related services.

Abstract: Systems and methods for digital property authentication and management are disclosed. A document representing a trade secret may be requested to be registered with a trade secret registry. A document obfuscation value corresponding to the document may be generated and may be registered with a blockchain. A record of the registration may be generated for the trade secret registry. The registry may be searchable and/or offer functionality such as valuation, insurance provision, and/or verification, among other benefits and functionalities.

Abstract: The present disclosure is directed to systems and methods for developing an individual-specific patient baseline for a target patient. An exemplary method involves: determining one or more acuity scores for the target patient; identifying patient health data corresponding to one or more low acuity time periods; storing retrospective clinical data from a group of patients in a second database; comparing the patient health data corresponding to the one or more low acuity time periods with retrospective clinical data from a group of patients by identifying one or more patient subgroups; determining the individual-specific patient baseline using an adaptive baseline selection algorithm, wherein the adaptive baseline selection algorithm is used to determine whether to determine the individual-specific patient baseline using patient health data or using retrospective clinical data from one or more patient subgroups; and displaying, using a user interface, the individual-specific patient baseline.

Abstract: Disclosed herein are adjuvanted protein vaccines comprising: a SARS-CoV-2 variant C.1.2 modified S1 Spike protein sequence and a non-phospholipid liposome, wherein the protein is encapsulated within the non-phospholipid liposome. The adjuvanted protein vaccines are suitable for subcutaneous administration. Also disclosed herein are modified spike protein sequences containing SARS-CoV-2 variant C.1.2 modified S1 Spike proteins and methods of use of the vaccines and sequences.

Abstract: In some examples, a computing device creates an event log when an event occurs. If the event log includes a path comprising one or more components, the computing device may determine a hash, using a hash function and a salt, for each of the components and substitute each component in the path with an index to the hash stored in a dictionary. In this way, the computing device replaces each component of the path with an index to a hash in the dictionary to create a modified path. The resulting modified path can be traversed and searched. For example, a search term may be hashed using the hash function and salt, and the dictionary associated with the logs searched for a match. In this way, a particular file name or a particular folder name can be identified in the modified path.

Abstract: Systems may evaluate a claim or patent with respect to a related set of claims or patent documents. The systems may perform linguistic analyses of claims included in the patent and the related set of patent documents. Based on the linguistic analyses, the systems may identify claim limitations, and/or claim elements. The systems may generate a claim profile for each claim being evaluated. The claim profile may include ratings or scores for various metrics related to the claims being evaluated. The systems may also generate a peer group profile that provides an overall measure of metrics for claims included in a peer group of patent documents.

Abstract: Systems and methods for generation and use of document analysis architectures are disclosed. A model builder component may be utilized to receiving user input data for labeling a set of documents as in class or out of class. That user input data may be utilized to train one or more classification models, which may then be utilized to predict classification of other documents. Trained models may be incorporated into a model taxonomy for searching and use by other users for document analysis purposes.

Abstract: Systems and methods are provided for evaluating performance of a heat exchanger, such as a condenser, using rules-based logic. A plurality of sensors can measure various operating properties of the heat exchanger and transmit corresponding measurement information to a controller. The controller can (i) evaluate the measurement information for a plurality of rules in which each rule considers an operating parameter of the heat exchanger that is based on the measurement information to provide a set of operating values; compare the set of operating values to a rules matrix in which each of a plurality of possible diagnoses for the heat exchanger are associated with a corresponding set of predetermined values from a set of the plurality of rules; and (iii) based on the comparison, determine at least one likely diagnosis for the heat exchanger from among the plurality of possible diagnoses.

Abstract: Techniques described herein are directed to analyzing intellectual-property data according to provide various intellectual property related services to organizations. In particular implementations, information related to products and/or services may be obtained from a number of data sources. Additionally, information related to intellectual-property assets, such as patents, trademarks, copyrights, trade secrets, and know-how, may be obtained. In various situations, the intellectual-property assets may be mapped to respective products and/or services. The mappings between the products and/or services and intellectual-property assets may be used to provide intellectual property related services that correspond to the intellectual-property assets, such as valuation services, strategy-related services, or risk-related services.

Abstract: Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.

Abstract: Disclosed herein are compounds of Formula I: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.

Abstract: This invention relates to a light weight microtube heat exchanger that meets all the performance requirements of more conventional plate-fin heat exchangers (thermal performance, shock and vibration, and weight, etc.) while providing significant improvements with respect to air-side fouling due to sand and dirt or weight reduction.

Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a patient with one or more of the above compounds.

Abstract: Systems and methods for dataset distinctiveness modeling are disclosed. For example, databases may be queried for datasets associated with intellectual property assets, particularly trademarks. A vector representation may be generated for the mark in question, and a vector representation may be generated for the description of goods and/or services associated with the mark. A machine learning model may be trained to predict a distinctiveness score based on the vector representations, similarity metrics between the trademark and other marks, goods and services of the other marks, and context data associated with the trademarks.

Abstract: Systems and methods for dataset distinctiveness modeling are disclosed. For example, databases may be queried for datasets associated with intellectual property assets, particularly trademarks. A vector representation may be generated for the mark in question, and a vector representation may be generated for the description of goods and/or services associated with the mark. A machine learning model may be trained to predict a distinctiveness score based on the vector representations, similarity metrics between the trademark and other marks, goods and services of the other marks, and context data associated with the trademarks.

Abstract: Techniques described herein are directed to analyzing intellectual-property data according to provide various intellectual property related services to organizations. In particular implementations, information related to products and/or services may be obtained from a number of data sources. Additionally, information related to intellectual-property assets, such as patents, trademarks, copyrights, trade secrets, and know-how, may be obtained. In various situations, the intellectual-property assets may be mapped to respective products and/or services. The mappings between the products and/or services and intellectual-property assets may be used to provide intellectual property related services that correspond to the intellectual-property assets, such as valuation services, strategy-related services, or risk-related services.