Abstract: Disclosed are methods of eliminating at least on target cell in a subject, comprising administering to the subject an effective amount of a composition comprising a plurality of immune cells, wherein each immune cell of the plurality expresses one or more chimeric ligand receptor(s) (CLR(s)) that each specifically bind to a target ligand on the at least one target cell, wherein specifically binding of the one or more CLR(s) to the target activates the immune cell, and wherein the activated immune cell induces death of the target cell. Exemplary target cells include, but are not limited to, hematopoietic stem cells (HSCs).

Abstract: The invention relates to compounds of formula (I) which are inhibitors of kinase activity, pharmaceutical formulations containing the compounds and their uses in treating and preventing viral infections and disorders caused or exacerbated by the viral infection wherein R1, R2, R3, R4a, R4b, R4c, R5, W, X, Y and Z are defined herein.

Abstract: The invention is directed to compounds of formula (I), and salts thereof. The compounds are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to compounds of formula (I), and salts thereof. The compounds are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention relates to compounds of formula (I) which are inhibitors of kinase activity, pharmaceutical formulations containing the compounds and their uses in treating and preventing viral infections and disorders caused or exacerbated by the viral infection wherein R1, R2, R3, R4a, R4b, R4c, R5, W, X, Y and Z are defined herein.

Abstract: A system for deploying a first object for capturing, immobilising or disabling a second object is provided. The system comprises the first object, a projectile for carrying the first object therein, and a launcher for launching the projectile towards the second object, wherein the projectile is configured for deploying the first object in the vicinity of the second object for capturing, immobilising or disabling the second object.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: Disclosed are methods of eliminating at least on target cell in a subject, comprising administering to the subject an effective amount of a composition comprising a plurality of immune cells, wherein each immune cell of the plurality expresses one or more chimeric ligand receptor(s) (CLR(s)) that each specifically bind to a target ligand on the at least one target cell, wherein specifically binding of the one or more CLR(s) to the target activates the immune cell, and wherein the activated immune cell induces death of the target cell. Exemplary target cells include, but are not limited to, hematopoietic stem cells (HSCs).

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: A system for inhibiting the electronic system of a target object is provided. The system comprises an Electronic Counter Measure (ECM) unit, and a projectile for carrying the ECM unit towards the target object.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: A method for acquiring a remote object is provided. The method comprises obtaining a sequence of position samples of the remote object, identifying one or more sets of spatially clustered position samples from among the obtained position samples, and applying curve-fitting to at least one set of spatially clustered position samples to obtain a trajectory of the set of spatially clustered position samples. Also provided is a method for tracking a remote object. The method comprising obtaining an estimated trajectory of the object, obtaining one or more position samples of the object, comparing the obtained position samples with positions computed based on the estimated trajectory, and determining that the object is being tracked based on whether the obtained position samples are consistent with the computed positions.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: A system for inhibiting the electronic system of a target object is provided. The system comprises an Electronic Counter Measure (ECM) unit, and a projectile for carrying the ECM unit towards the target object.

Abstract: A method for acquiring a remote object is provided. The method comprises obtaining a sequence of position samples of the remote object, identifying one or more sets of spatially clustered position samples from among the obtained position samples, and applying curve-fitting to at least one set of spatially clustered position samples to obtain a trajectory of the set of spatially clustered position samples. Also provided is a method for tracking a remote object. The method comprising obtaining an estimated trajectory of the object, obtaining one or more position samples of the object, comparing the obtained position samples with positions computed based on the estimated trajectory, and determining that the object is being tracked based on whether the obtained position samples are consistent with the computed positions.

Abstract: Friction reducers for hydraulic fracturing fluids, hydraulic fracturing fluids containing the friction reducers, and methods of making and using same are disclosed. The friction reducers comprise ethylene oxide polymers, propylene oxide polymers, ethylene oxide-propylene oxide co-polymers, and combinations thereof, and can further comprise a dispersant, such as polypropylene glycol. The friction reducer formulations can be active across a wide range of brine salinities, and tolerant of high levels of divalent cations in solution. The friction reducers can have a cloud point temperature, above which temperature they can precipitate out of solution and deposit on a surface of a hydrocarbon-bearing formation to inhibit hydration of the shale formations lining the fractures.

Abstract: A system for deploying a first object for capturing, immobilising or disabling a second object is provided. The system comprises the first object, a projectile for carrying the first object therein,and a launcher for launching the projectile towards the second object,wherein the projectile is configured for deploying the first object in the vicinity of the second object for capturing, immobilising or disabling the second object.

Abstract: Friction reducers for hydraulic fracturing fluids, hydraulic fracturing fluids containing the friction reducers, and methods of making and using same are disclosed. The friction reducers comprise ethylene oxide polymers, propylene oxide polymers, ethylene oxide-propylene oxide co-polymers, and combinations thereof, and can further comprise a dispersant, such as polypropylene glycol. The friction reducer formulations can be active across a wide range of brine salinities, and tolerant of high levels of divalent cations in solution. The friction reducers can have a cloud point temperature, above which temperature they can precipitate out of solution and deposit on a surface of a hydrocarbon-bearing formation to inhibit hydration of the shale formations lining the fractures.

Abstract: Processes for preparing extracts of natural products such as plant material, and for preparing purified extracts from crude extracts of natural products, by extraction with hot gas. Apparatus suitable for use in preparing extracts of natural products are also described.

Abstract: The present invention provides novel methods for enhancing the delivery of transduced cells to a subject, which include both methods of selecting for transduced cells and methods of enhancing the reconstitution by transduced cells in a transplant recipient. The present invention further provides transfer vectors, including lentiviral vectors, useful in practicing the methods of the present invention. The methods and vectors of the present invention may be used in gene therapy of a variety of diseases and disorders, including but not limited to hematological diseases and disorders.