Patents by Inventor David A. Driver

David A. Driver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for generating an immune response utilizing alphavirus-based vector systems
    Patent number: 8647864
    Abstract: Compositions and methods are provided for Eukaryotic Layered Vector Initiation Systems and Alphavirus replicon particles for introducing heterologous sequences into cells for generating immune responses.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: February 11, 2014
    Assignee: Novartis AG
    Inventors: John M Polo, Thomas W Dubensky, Jr., Ilya Frolov, Jason P Gardner, Gillis Otten, Susan Barnett, David A Driver
  • Eukaryotic layered vector initiation systems
    Patent number: 7977091
    Abstract: The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: July 12, 2011
    Assignee: Novartis Vaccines & Diagnostics, Inc.
    Inventors: Thomas W. Dubensky, Jr., John M Polo, Carlos E Ibanez, Stephen M. W. Chang, Douglas J Jolly, David A Driver, Barbara A Belli
  • Compositions and Methods for Generating an Immune Response Utilizing Alphavirus-Based Vector Systems
    Publication number: 20100266631
    Abstract: Compositions and methods are provided for Eukaryotic Layered Vector Initiation Systems and Alphavirus replicon particles for introducing heterologous sequences into cells for generating immune responses.
    Type: Application
    Filed: June 29, 2010
    Publication date: October 21, 2010
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS, INC.
    Inventors: John Polo, Thomas W. Dubensky, JR., Ilya Frolov, Jason P. Gardner, Gillis Otten, Susan Barnett, David A. Driver
  • Compositions and methods for generating an immune response utilizing alphavirus-based vector systems
    Patent number: 7771979
    Abstract: Methods are provided for generating immune responses utilizing alphavirus-based vector systems.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: August 10, 2010
    Assignee: Novartis Vaccines & Diagnostics, Inc.
    Inventors: John Polo, Thomas W. Dubensky, Jr., Ilya Frolov, Jason P. Gardner, Gillis Otten, Susan Barnett, David A. Driver
  • Eukaryotic Layered Vector Initiation Systems
    Publication number: 20100173412
    Abstract: The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors.
    Type: Application
    Filed: August 10, 2009
    Publication date: July 8, 2010
    Inventors: Thomas W. Dubensky, JR., John M. Polo, Carlos E. Ibanez, Stephen M.W. Chang, Douglas J. Jolly, David A. Driver, Barbara A. Belli
  • Eukaryotic layered vector initiation systems
    Patent number: 7572628
    Abstract: The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: August 11, 2009
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, Carlos E. Ibanez, Stephen M. W. Chang, Douglas J. Jolly, David A. Driver, Barbara A. Belli
  • Compositions and methods for generating an immune response utilizing alphavirus-based vector systems
    Publication number: 20080226598
    Abstract: Methods are provided for generating immune responses utilizing alphavirus-based vector systems.
    Type: Application
    Filed: February 27, 2007
    Publication date: September 18, 2008
    Inventors: John Polo, Thomas W. Dubensky, Ilya Frolov, Jason P. Gardner, Gillis Otten, Susan Barnett, David A. Driver
  • Eukaryotic layered vector initiation systems
    Publication number: 20040029278
    Abstract: The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Application
    Filed: May 17, 2002
    Publication date: February 12, 2004
    Applicant: Chiron Corporation
    Inventors: Thomas W. Dubensky, John M. Polo, Carlos E. Ibanez, Stephen M.W. Chang, Douglas J. Jolly, David A. Driver, Barbara A. Belli
  • Eukaryotic layered vector initiation systems
    Publication number: 20030232035
    Abstract: The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Application
    Filed: January 16, 2003
    Publication date: December 18, 2003
    Inventors: Thomas W. Dubensky, John M. Polo, Carlos E. Ibanez, Stephen M.W. Chang, Douglas J. Jolly, David A. Driver, Barbara A. Belli
  • Recombinant alphavirus particles
    Patent number: 6376236
    Abstract: Disclosed are recombinant alphavirus particles comprising a) an alphavirus vector construct which directs the expression of a heterologous nucleic acid molecule; b) a capsid protein; and c) an envelope glycoprotein from a virus different from said alphavirus vector.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: April 23, 2002
    Assignee: Chiron Corporation
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, Carlos E. Ibanez, David A. Driver
  • Eukaryotic layered vector initiation systems for production of recombinant proteins
    Patent number: 6342372
    Abstract: The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: January 29, 2002
    Assignee: Chiron Corporation
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, David A. Driver
  • Crossless retroviral vectors
    Patent number: 6333195
    Abstract: Retroviral vector constructs are described which have a 5′ LTR, a tRNA binding site, a packaging signal, one or more heterologous sequences, an origin of second strand synthesis and a 3′ LTR, wherein the vector construct lacks retroviral gag/pol or env coding sequences. In addition, gag/pol, and env expression cassettes are described wherein the expression cassettes lack a consecutive sequence of more than 8 nucleotides in common. The above-described retroviral vector constructs, gag/pol and env expression cassettes may be utilized to construct producer cell lines which preclude the formation of replication competent virus.
    Type: Grant
    Filed: January 7, 2000
    Date of Patent: December 25, 2001
    Assignee: Chiron Corporation
    Inventors: James G. Respess, Nicholas J. DePolo, Sunil Chada, Sybille Sauter, Mordechai Bodner, David A. Driver
  • Eukaryotic layered vector initiation systems
    Patent number: 6015686
    Abstract: The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Grant
    Filed: March 15, 1995
    Date of Patent: January 18, 2000
    Assignee: Chiron Viagene, Inc.
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, Douglas J. Jolly, David A. Driver
  • Crossless retroviral vectors
    Patent number: 6013517
    Abstract: Retroviral vector constructs are described which have a 5' LTR, a tRNA binding site, a packaging signal, one or more heterologous sequences, an origin of second strand synthesis and a 3' LTR, wherein the vector construct lacks retroviral gag/pol or env coding sequences. In addition, gag/pol, and env expression-cassettes are described wherein the expression cassettes lack a consecutive sequence of more than 8 nucleotides in common. The above-described retroviral vector constructs, gag/pol and env expression cassettes may be utilized to construct producer cell lines which preclude the formation of replication competent virus.
    Type: Grant
    Filed: May 5, 1997
    Date of Patent: January 11, 2000
    Assignee: Chiron Corporation
    Inventors: James G. Respess, Nicholas J. DePolo, Sunil Chada, Sybille Sauter, Mordechai Bodner, David A. Driver
  • Alphavirus vector constructs
    Patent number: 5843723
    Abstract: The present invention provides compositions and method,, for utilizing recombinant alphavirus vectors.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: December 1, 1998
    Assignee: Chiron Corporation
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, Carlos E. Ibanez, Stephen M. W. Chang, Douglas J. Jolly, David A. Driver, Barbara A. Belli
  • Eukaryotic layered vector initiation systems
    Patent number: 5814482
    Abstract: The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: September 29, 1998
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, Douglas J. Jolly, David A. Driver
  • Alphavirus structural protein expression cassettes
    Patent number: 5789245
    Abstract: The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: August 4, 1998
    Assignee: Chiron Corporation
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, Carlos E. Ibanez, Stephen M. W. Chang, Douglas J. Jolly, David A. Driver