Abstract: Methods and apparatus for detecting false alarms are disclosed. An indication may be received that a sensor device has changed state. Data indicative of movement of the sensor device may also be received. Based on the received data indicative of movement of the sensor device, it may be determined whether the movement of the sensor device is abnormal. Based on the changed state of the sensor device and based on determining that the movement of the sensor device is abnormal, an indication of a false alarm may be caused to be output.

Abstract: The present invention encompasses antagonist anti-CD40 antibodies and antigen-binding portions thereof. Specifically, the invention relates to humanized anti-CD40 antibodies. In certain embodiments, antibodies of the invention neutralize human CD40 (hCD40) activity. Antibodies, or antibody portions, of the invention are useful for detecting CD40 and for inhibiting CD40 activity, e.g., in a human subject suffering from a disorder in which CD40 activity is detrimental.

Abstract: The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).

Abstract: The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).

Abstract: The present invention encompasses antagonist anti-CD40 antibodies and antigen-binding portions thereof. Specifically, the invention relates to humanized anti-CD40 antibodies. In certain embodiments, antibodies of the invention neutralize human CD40 (hCD40) activity. Antibodies, or antibody portions, of the invention are useful for detecting CD40 and for inhibiting CD40 activity, e.g., in a human subject suffering from a disorder in which CD40 activity is detrimental.

Abstract: An online system provides a social networking environment for a set of users, such as members of an organization. The online system allows generation of groups of users within the set to allow users to more easily communicate content with other users. When a user creates a new group, the online system identifies multiple categories to the user, and the user selects a category for association with the group. Categories are associated with access rights regulating user access to content associated with the group or users capable of performing various actions with the group. Additionally, a member of the group may invite entities outside of the online system, or outside of the set of users, to join the group. If the entity joins the group, the online system provides content associated with the group to the entity, allowing the entity to receive content from the group.

Abstract: The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).

Abstract: The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).

Abstract: An online system allows users to join groups and interact with other members of group that they have joined. The online system identifies relationships between users in an organization using information about the users, such as roles and connections from an organizational chart. The online system establishes inferred connections between the users based on information from the organizational chart. The online system then determines whether to make group content visible to a user by applying visibility criteria for a group to the inferred connections between a user and members of the group, if any. Depending on this determination, groups are then made visible to certain users by presenting content associated with the group to the user.

Abstract: Disclosed herein is a system and computer implemented method for detecting extraordinary demand of a consumable(s) for processing biological samples by laboratory instrument(s) in a plurality of laboratories based on exceptional deviations from usual demand levels of trigger laboratories in the proximity of a target laboratory.

Abstract: An online system provides a social networking environment for a set of users, such as members of an organization. The online system allows generation of groups of users within the set to allow users to more easily communicate content with other users. When a user creates a new group, the online system identifies multiple categories to the user, and the user selects a category for association with the group. Categories are associated with access rights regulating user access to content associated with the group or users capable of performing various actions with the group. Additionally, a member of the group may invite entities outside of the online system, or outside of the set of users, to join the group. If the entity joins the group, the online system provides content associated with the group to the entity, allowing the entity to receive content from the group.

Abstract: An online system allows users to join groups and interact with other members of group that they have joined. The online system identifies relationships between users in an organization using information about the users, such as roles and connections from an organizational chart. The online system establishes inferred connections between the users based on information from the organizational chart. The online system then determines whether to make group content visible to a user by applying visibility criteria for a group to the inferred connections between a user and members of the group, if any. Depending on this determination, groups are then made visible to certain users by presenting content associated with the group to the user.

Abstract: The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).

Abstract: Systems, computer implemented methods, and computer readable media select potential meeting times and meeting locations. Meeting parameters are generated for a meeting request. Scores for each of a plurality of meeting times are generated based on the meeting parameters. Scores for each of a plurality of meeting locations are generated based on the meeting parameters. One or more potential meeting time and meeting location pairs are selected based on the scores for each of the plurality of meeting times and the scores for each of the plurality of meeting locations.

Abstract: The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).

Abstract: A method of producing a high-density abrasive compact material includes the steps of providing an electrically conductive mixture of a bonding powder material and abrasive particles or grit; compressing the electrically conductive mixture; and subjecting the compressed electrically conductive mixture to one or more high current pulses to form the abrasive compact is provided.

Abstract: The invention relates to a process for the formation of pellets containing an ultra hard core coated with an encapsulating material, the process including the steps of suspending ultra hard core material in a flow of gas; contacting the ultra hard core material with encapsulating to form pellets, introducing the pellets into a rotating vessel and contacting the pellets with encapsulating material to form pellets of greater mass than the pellets introduced into the rotating vessel. The invention also relates to a pellet containing an ultra hard core coated with an encapsulating material whenever produced by a process as hereinbefore described.

Abstract: A method of producing a high-density abrasive compact material includes the steps of providing an electrically conductive mixture of a bonding powder material and abrasive particles or grit; compressing the electrically conductive mixture; and subjecting the compressed electrically conductive mixture to one or more high current pulses to form the abrasive compact is provided.

Abstract: A coated super-hard abrasive comprises a core of super-hard abrasive material, typically diamond or cBN based, an inner layer of a metal carbide, nitride, boride, carbonitride or boronitride chemically bonded to an outer surface of the super-hard abrasive material and an outer layer of a metal, metal alloy or a combination of metals or metal alloys deposited on the inner layer. Examples of metals or metal alloys that can be applied as an outer layer include metals from group IVa, Va or Vla transition metals, including tungsten, titanium, chromium, molybdenum, and zirconium, and metals from the first row transition metals (Ti to Cu), particularly the non magnetic metals or alloys of these that are amenable to magnetron sputtering, and elements from groups IIIb and IVb of the periodic table, such as B, Al, Si.

Abstract: A coated super-hard abrasive comprises a core of super-hard abrasive material, which is typically diamond or cBN based, an inner layer of a metal carbide, nitride, boride or carbonitride chemically bonded to an outer surface of the super-hard abrasive material and an outer layer of a metal carbonitride, in particular titanium carbonitride. The outer layer is preferably applied by physical vapour deposition. The inner layer is formed from an element capable of forming (singly or in combination) carbides, nitrides or borides to the surface(s) of the abrasive material when applied using a hot coating process.