Abstract: A process can be used for preparing nanoparticles containing at least one bio-resorbable polyester. The nanoparticles are in the form of a powder with a Z-Average particle size Dz in the range of 1 to 450 nm, and with a polydispersity index PDI in the range of 0.01 to 0.5. The process involves emulsion-solvent extraction or emulsion-solvent evaporation, and application of ultrasonic sound.

Abstract: A method for determining the position of a non-motorized road user including ascertaining a first geodetic position of the road user in a position determination device, which uses a global navigation satellite system, of the terminal, and transmitting the first geodetic position to a traffic device. In a control unit of the traffic device, ascertaining a second geodetic position of the road user from a geodetic traffic device position and a relative position ascertained from sensor data, showing the road user, of at least one surroundings sensor of the traffic device. At least if a limiting value for a deviation of the first position from the second position is exceeded, transmitting an item of deviation information describing the second position and/or the deviation from the traffic device to the mobile terminal, and using the deviation information to correct the position ascertainment in the position determination device.

Abstract: The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

Abstract: Devices, systems and methods for cutting openings in a wellbore tubular by a slot cutting assembly having an anchoring system and a slot cutting tool. The anchoring assembly anchors the slot cutting assembly within the wellbore. The slot cutting tool has an extendable cutting blade that is pushed into the wellbore tubular to cut an opening through the tubular. The slot cutting tool may have an extendable stabilizing arm to stabilize and assist with cutting by the blade. The slot cutting assembly may have azimuth and depth sensors to assist with positioning the tool at a desired position downhole. A surface system may be used to control the position of the slot cutting assembly downhole.

Abstract: Systems and methods presented herein provide for cutting in a borehole or casing. A cutting device can include a first arm having a cutting blade, wherein the cutting blade has side cutting teeth and an axis of rotation that is substantially at a right angle with respect to an axis of the tool body. The cutting device can also include a second arm with a bumper. The first and second arms articulate away from the elongate body in different directions to reduce vibrations while cutting. A control device can automate the cut based on hydraulic pressure measurements. Additionally, the cutting device can also be extended or rotated on a rotary index. The cutting device can rotate around a J slot, in an example.

Abstract: The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

Abstract: The present invention is related to an inhibitor or antagonist of SHP2 for the treatment and/or prevention of a neoplastic disease.

Abstract: An appliance pad that is applicable to protecting kitchen appliances, such as a range or stove, is described. The appliance pad is manufactured of a polymer such that a bottom surface of the pad has a hardness so that the pad adheres to at least a portion of a front shelf of the appliance. The front shelf of the appliance where the pad is installed is a portion of the appliance between a cooking section of the appliance and the user. The pad also provides protection of excess heat conducted by the front shelf.

Abstract: The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

Abstract: An intrusion detection system and methods thereof are provided. In exemplary embodiments, the system may comprise an upper scanner adapted to create a first detection layer; a lower scanner adapted to create a second detection layer, the second detection layer overlapping the first detection layer; signal lighting for producing a visual signal; at least one server adapted analyze data received from the upper scanner and the lower scanner to determine if an object is in the path of the vehicle; and wherein the at least one server is adapted to activate the signal lighting when it is determined by the server that an object is in the path of the vehicle.

Abstract: An electrical instrument swivel connector has a first housing part and a second housing part rotatably connected to each other. The connection enabling transfer of axial loading between the housing parts. A first insulator body is rotatably engaged with a second insulator body and respectively sealingly engageable with an interior surface of the first housing part and the second housing part. Electrical contact pins are formed into the first insulator body and the second insulator body. The electrical contact pins each terminate in a separate electrical contact wherein the first insulator body rotatably engages the second insulator body. A biased electrical contact is disposed between each respective separate electrical contact in the first insulator body and the second insulator body.

Abstract: An electrical instrument swivel connector has a first housing part and a second housing part rotatably connected to each other. The connection enabling transfer of axial loading between the housing parts. A first insulator body is rotatably engaged with a second insulator body and respectively sealingly engageable with an interior surface of the first housing part and the second housing part. Electrical contact pins are formed into the first insulator body and the second insulator body. The electrical contact pins each terminate in a separate electrical contact wherein the first insulator body rotatably engages the second insulator body. A biased electrical contact is disposed between each respective separate electrical contact in the first insulator body and the second insulator body.

Abstract: An intrusion detection system and methods thereof are provided. In exemplary embodiments, the system may comprise an upper scanner adapted to create a first detection layer; a lower scanner adapted to create a second detection layer, the second detection layer overlapping the first detection layer; signal lighting for producing a visual signal; at least one server adapted analyze data received from the upper scanner and the lower scanner to determine if an object is in the path of the vehicle; and wherein the at least one server is adapted to activate the signal lighting when it is determined by the server that an object is in the path of the vehicle.

Abstract: The present invention discloses a method and apparatus for minimizing accelerations during impacts such as those encountered in motor vehicle accidents, helicopter and airplane crashes, explosions, and the like. The preferred embodiment takes the form of a helical spring-like member (100), designed to experience plastic deformation over a desired deformation length, under a given impact load threshold. The spring-like member is preferably installed in a mechanical linkage that is flattened under impact, straining the spring-like member in a predictable fashion. The operating characteristics of this system [namely the stress-strain curve, and thus the deformation length, impact load threshold, and acceptable load range for the system to be protected] can be easily controlled by varying the device dimensions and installation configuration.

Abstract: An intrusion detection system and methods thereof are provided. In exemplary embodiments, the system may comprise an upper scanner adapted to create a first detection layer; a lower scanner adapted to create a second detection layer, the second detection layer overlapping the first detection layer; signal lighting for producing a visual signal; at least one server adapted analyze data received from the upper scanner and the lower scanner to determine if an object is in the path of the vehicle; and wherein the at least one server is adapted to activate the signal lighting when it is determined by the server that an object is in the path of the vehicle.

Abstract: An energy absorbing device for carrying a passenger seat; the device comprises a base fixed to a vehicle; a member displaceable from base; at least one energy-absorbing arrangement interconnecting base and displaceable member. The energy-absorbing arrangement comprises a plastically deformable absorbing element in response to stresses greater than a predetermined threshold stress. In some embodiments the plastically deformable absorbing element is a helically configured ribbon having spaced-apart ribbon laps. In other embodiments the plastically deformable absorbing element is compressible, and/or extendable.

Abstract: An energy absorbing device for carrying a passenger seat; the device comprises a base fixed to a vehicle; a member displaceable from base; at least one energy-absorbing arrangement interconnecting base and displaceable member. The energy-absorbing arrangement comprises a plastically deformable absorbing element in response to stresses greater than a predetermined threshold stress. In some embodiments the plastically deformable absorbing element is a helically configured ribbon having spaced-apart ribbon laps. In other embodiments the plastically deformable absorbing element is compressible, and/or extendable.

Abstract: The present invention provides an energy absorbing element (200) (EAE) useful for limiting forces transmitted to an object attached thereto, said element comprising a hollow extruded member provided with threads (230), having a helical cut (210) through the wall of said member, said helical cut and the extrusion axis of said member being coaxial, said member being adapted to undergo deformation when under strain, whereby the force-displacement curve of said spacer when under strain is of a predetermined form and wherein said element may be stretched or compress by a length depending upon the pitch of said helical cut such that forces transmitted to said object are limited.

Abstract: A shock absorbing device adapted for mounting at a substantially vertical surface is disclosed. The aforesaid device comprises (a) vertically spaced-apart two pulleys being mechanically securable to the vertical surface; (b) an elongate member; the elongate member provided with two terminals; the member adapted for reciprocative motion along the elongate member; the member adapted for mechanically securing a subject to be protected; (c) a wire connected to the terminals of the member and tensioned through the pulleys. The device further comprises an energy absorber.

Abstract: Systems and methods for manufacturing a customized publication are provided. The method may comprise printing a first set of customized components for each publication. The first set may include a component customized to a recipient. The method may further provide for printing a second set of customized components for each publication. The second set may include a component that is customized to the recipient. The method may even further provide for associating the component from the first set with the component from the second set to form a customized publication section for the recipient. In various embodiments, the method may further comprise providing the customized publication section for associating with an uncustomized section. Accessing a database storing recipient data, wherein the recipient data is used to print the customized components from the first and second sets for the recipient may also be provided.