Patents by Inventor David A. Engers
David A. Engers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11299458Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.Type: GrantFiled: August 14, 2020Date of Patent: April 12, 2022Assignee: OTSUKA AMERICA PHARMACEUTICAL, INC.Inventors: Anthony Alexander McKinney, Franklin Bymaster, Walter Piskorski, Fred J. Fleitz, Yonglai Yang, David A. Engers, Valeriya Smolenskaya, Venkat Kusukuntla
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Publication number: 20210388532Abstract: A method of producing electrically conductive metallic structures in or on textiles, which has the following steps: (a) introducing at least one non-conducting precursor compound into a fibre or yarn material during or after the production thereof, wherein the at least one precursor compound is an inorganic metal phosphate compounds, a metal oxide or a spinel of the general formula AB2O4, (b) producing a textile from the fibre or yarn material, (c) irradiating the textile with electromagnetic radiation, preferably with laser light in the regions of the electrically conductive structures to be produced, with the release of metallisation seeds, and (d) electrical or non-electrical treatment of the textile with deposit of metals at the metallisation seeds with the production of conductive structures in the textile.Type: ApplicationFiled: September 26, 2019Publication date: December 16, 2021Applicant: Chemische Fabrik Budenheim KGInventors: David ENGERS, Thomas FUTTERER, Tobias MOSS, Gideon RATH, Rüdiger WISSEMBORSKI
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Publication number: 20210198198Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.Type: ApplicationFiled: August 14, 2020Publication date: July 1, 2021Inventors: Anthony Alexander MCKINNEY, Franklin BYMASTER, Walter PISKORSKI, Fred J. FLEITZ, Yonglai YANG, David A. ENGERS, Valeriya SMOLENSKAYA, Venkat KUSUKUNTLA
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Patent number: 10800740Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.Type: GrantFiled: March 11, 2019Date of Patent: October 13, 2020Assignee: OTSUKA AMERICA PHARMACEUTICAL, INC.Inventors: Anthony Alexander McKinney, Franklin Bymaster, Walter Piskorski, Fred J. Fleitz, Yonglai Yang, David A. Engers, Valeriya Smolenskaya, Venkat Kusukuntla
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Patent number: 10793437Abstract: A method for the manufacture of crystal water-free iron(II) orthophosphate of the general formula Fe3(PO4)2 or crystal water-free iron(II) metal orthophosphate, iron(II) metal pyrophosphate or iron(II) metal metaphosphate of the general formula FeaMetb(POc)d, where a is a number from 1 to 5, b is a number from >0 to 5, c is a number from 2.5 to 5, d is a number from 0.5 to 3 and Met represents one or more metals selected from the group consisting of K, Rb, Cs, Mg, Ca, Sr, Ba, the transition metals (d block), in particular Sc, Y, La, Ti, Zr, Hf, Nb, Ta, Cr, Mo, W, Mn, Cu, Zn and the metals and semimetals of the third, fourth and fifth main groups, in particular B, Al, Ga, In, Si, Sn, Sb, Bi and the lanthanoids.Type: GrantFiled: March 26, 2018Date of Patent: October 6, 2020Assignee: Chemische Fabrik Budenheim KGInventors: Joachim Adolf, Dominik Braun, Gerhard Eich, David Engers, Bastian Ewald, Christian Litterscheid, Rüdiger Wissemborski
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Publication number: 20200095127Abstract: A method for the manufacture of crystal water-free iron(II) orthophosphate of the general formula Fe3(PO4)2 or crystal water-free iron(II) metal orthophosphate, iron(II) metal pyrophosphate or iron(II) metal metaphosphate of the general formula FeaMetb(POc)d, where a is a number from 1 to 5, b is a number from >0 to 5, c is a number from 2.5 to 5, d is a number from 0.5 to 3 and Met represents one or more metals selected from the group consisting of K, Rb, Cs, Mg, Ca, Sr, Ba, the transition metals (d block), in particular Sc, Y, La, Ti, Zr, Hf, Nb, Ta, Cr, Mo, W, Mn, Cu, Zn and the metals and semimetals of the third, fourth and fifth main groups, in particular B, Al, Ga, In, Si, Sn, Sb, Bi and the lanthanoids.Type: ApplicationFiled: March 26, 2018Publication date: March 26, 2020Applicant: Chemische Fabrik Budenheim KGInventors: Joachim ADOLF, Dominik BRAUN, Gerhard EICH, David ENGERS, Bastian EWALD, Christian LITTERSCHEID, Rüdiger WISSEMBORSKI
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Publication number: 20200039934Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.Type: ApplicationFiled: March 11, 2019Publication date: February 6, 2020Inventors: Anthony Alexander MCKINNEY, Franklin Bymaster, Walter Piskorski, Fred J. Fleitz, Yonglai Yang, David A. Engers, Valeriya Smolenskaya, Venkat Kusukuntla
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Patent number: 10280141Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.Type: GrantFiled: November 21, 2017Date of Patent: May 7, 2019Assignee: OTSUKA AMERICA PHARMACEUTICAL, INC.Inventors: Anthony Alexander McKinney, Franklin Bymaster, Walter Piskorski, Fred J. Fleitz, Yonglai Yang, David A. Engers, Valeriya Smolenskaya, Venkat Kusukuntla
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Publication number: 20180194726Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.Type: ApplicationFiled: November 21, 2017Publication date: July 12, 2018Inventors: Anthony Alexander MCKINNEY, Franklin Bymaster, Walter Piskorski, Fred J. Fleitz, Yonglai Yang, David A. Engers, Valeriya Smolenskaya, Venkat Kusukuntla
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Patent number: 9856217Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.Type: GrantFiled: June 1, 2017Date of Patent: January 2, 2018Assignee: NEUROVANCE, INC.Inventors: Anthony Alexander McKinney, Franklin Bymaster, Walter Piskorski, Fred J. Fleitz, Yonglai Yang, David A. Engers, Valeriya Smolenskaya, Venkat Kusukuntla
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Publication number: 20170334850Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.Type: ApplicationFiled: June 1, 2017Publication date: November 23, 2017Inventors: Anthony Alexander MCKINNEY, Franklin BYMASTER, Walter PISKORSKI, Fred J. FLEITZ, Yonglai YANG, David A. ENGERS, Valeriya SMOLENSKAYA, Venkat KUSUKUNTLA
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Patent number: 9708261Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.Type: GrantFiled: June 17, 2016Date of Patent: July 18, 2017Assignee: NEUROVANCE, INC.Inventors: Anthony Alexander McKinney, Franklin Bymaster, Walter Piskorski, Fred J. Fleitz, Yonglai Yang, David A. Engers, Valeriya Smolenskaya, Venkat Kusukuntla
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Publication number: 20160368871Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.Type: ApplicationFiled: June 17, 2016Publication date: December 22, 2016Inventors: Anthony Alexander MCKINNEY, Franklin BYMASTER, Walter PISKORSKI, Fred J. FLEITZ, Yonglai YANG, David A. ENGERS, Valeriya SMOLENSKAYA
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Publication number: 20160136148Abstract: The invention relates to solid dispersions containing paroxetine mesylate. One solid dispersion contains amorphous paroxetine mesylate and a methacrylic acid-methyl methacrylate copolymer, where the weight ratio of paroxetine mesylate to polymer ranges from about 30:70 to about 90:10. Another solid dispersion contains amorphous paroxetine mesylate and a-vinylpyrrolidone/vinylacetate copolymer (PVP-VA), where the weight ratio of paroxetine mesylate to copolymer ranges from about 30:70 to about 50:50. An amorphous solid dispersion of the invention may have a single glass transition temperature. An amorphous solid dispersion is stable for at least 48 hours at 60° C. and 75% relative humidity. A further embodiment of the invention relates to pharmaceutical compositions of paroxetine mesylate comprising a solid dispersion of the invention and at least one pharmaceutically acceptable excipient.Type: ApplicationFiled: November 10, 2015Publication date: May 19, 2016Applicant: NOVEN THERAPEUTICS, LLCInventors: David A. Engers, Yonglai Yang, Stephen Parent, Travis Houston, Bruce Charles Friedman
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Patent number: 9211290Abstract: The invention relates to solid dispersions containing paroxetine mesylate. One solid dispersion contains amorphous paroxetine mesylate and a methacrylic acid-methyl methacrylate copolymer, where the weight ratio of paroxetine mesylate to polymer ranges from about 30:70 to about 90:10. Another solid dispersion contains amorphous paroxetine mesylate and a -vinylpyrrolidone/vinylacetate copolymer (PVP-VA), where the weight ratio of paroxetine mesylate to copolymer ranges from about 30:70 to about 50:50. An amorphous solid dispersion of the invention may have a single glass transition temperature. An amorphous solid dispersion is stable for at least 48 hours at 60° C. and 75% relative humidity. A further embodiment of the invention relates to pharmaceutical compositions of paroxetine mesylate comprising a solid dispersion of the invention and at least one pharmaceutically acceptable excipient.Type: GrantFiled: March 15, 2013Date of Patent: December 15, 2015Assignee: NOVEN THERAPEUTICS, LLCInventors: David A. Engers, Yonglai Yang, Stephan Parent, Travis Houston, Bruce Charles Friedman
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Publication number: 20140194510Abstract: The subject invention provides a solid dispersion of rasagiline citrate, a composition and a process for the manufacture thereof.Type: ApplicationFiled: March 10, 2014Publication date: July 10, 2014Applicant: Teva Pharmaceutical Industries Ltd.Inventors: Keith Lorimer, David Engers
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Publication number: 20140187582Abstract: The invention relates to solid dispersions containing paroxetine mesylate. One solid dispersion contains amorphous paroxetine mesylate and a methacrylic acid-methyl methacrylate copolymer, where the weight ratio of paroxetine mesylate to polymer ranges from about 30:70 to about 90:10. Another solid dispersion contains amorphous paroxetine mesylate and a -vinylpyrrolidone/vinylacetate copolymer (PVP-VA), where the weight ratio of paroxetine mesylate to copolymer ranges from about 30:70 to about 50:50. An amorphous solid dispersion of the invention may have a single glass transition temperature. An amorphous solid dispersion is stable for at least 48 hours at 60° C. and 75% relative humidity. A further embodiment of the invention relates to pharmaceutical compositions of paroxetine mesylate comprising a solid dispersion of the invention and at least one pharmaceutically acceptable excipient.Type: ApplicationFiled: March 15, 2013Publication date: July 3, 2014Inventors: David A. ENGERS, Yonglai YANG, Stephan PARENT, Travis HOUSTON, Bruce Charles FRIEDMAN
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Patent number: 8691872Abstract: The subject invention provides a solid dispersion of rasagiline citrate, a composition and a process for the manufacture thereof.Type: GrantFiled: July 27, 2011Date of Patent: April 8, 2014Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Keith Lorimer, David Engers
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Publication number: 20130158264Abstract: Polymorphic forms of the tyrosine kinase inhibitor OSI-906, preparation, pharmaceutical compositions, and uses thereof. The invention includes methods of treating diseases such as cancer, including cancer mediated at least in part by IGF-1 R and/or IR, with the polymorphs and compositions. This Abstract is not limiting of the invention.Type: ApplicationFiled: June 23, 2011Publication date: June 20, 2013Inventors: Arlindo L. Castelhano, David A. Enger, Jason A. Hanko, Josef A. Rechka, Jing Teng, Yonglai Yang
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Publication number: 20120190817Abstract: The present disclosure provides solid forms of a compound of formula I. In some embodiments, the present disclosure provides crystalline forms of Compound I. In some embodiments, the present disclosure provides solvate forms of Compound I. In some embodiments, the present disclosure provides amorphous Compound I.Type: ApplicationFiled: July 12, 2011Publication date: July 26, 2012Applicant: Celgene CorporationInventors: Jason Hanko, David Engers, Eric Hagen, Valeriya Smolenskaya, Jeffrey Stults