Patents by Inventor David A. Estell

David A. Estell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240327814
    Abstract: Disclosed are compositions and methods relating to variant maltohexaose-forming alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.
    Type: Application
    Filed: January 5, 2024
    Publication date: October 3, 2024
    Inventors: Luis G. CASCAO-PEREIRA, David A. ESTELL, Marc Anton Bernhard KOLKMAN, Harm MULDER
  • Patent number: 12104187
    Abstract: Disclosed herein is one or more subtilisin variant useful for cleaning applications and in methods of cleaning. One embodiment is directed to one or more subtilisin variant, including one or more Bacillus sp. subtilisin polypeptide variant, and one or more cleaning composition comprising one or more such variant.
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: October 1, 2024
    Assignee: Dansico US Inc.
    Inventors: Lilia Maria Babe, Viktor Yuryevich Alekseyev, Neelam S Amin, Joshua Roy Basler, David A Estell, Victoria Huang, David Marquez, Jeffrey Wayne Munos, Rei Otsuka, Geetha Veeramuthu, David Edward Wildes, Michelle Jackson, Euan John Magennis, Eva Maria Perez-Prat Vinuesa, Philip F. Souter, David John Tarbit
  • Publication number: 20240309352
    Abstract: The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant subtilisins suitable for laundry cleaning applications.
    Type: Application
    Filed: May 23, 2024
    Publication date: September 19, 2024
    Inventors: JOSHUA R. BASLER, LUIS G. CASCAO-PEREIRA, DAVID A. ESTELL, JAMES T. KELLIS, JR.
  • Publication number: 20240301383
    Abstract: The present disclosure provides AprL-clade protease enzymes, including variant AprL-clade protease enzymes, nucleic acids encoding same, and compositions and methods related to the production and use thereof, including an AprL-clade variant subtilisin enzyme that has improved stability and/or soil removal compared to a parent AprL-clade subtilisin enzyme.
    Type: Application
    Filed: September 30, 2022
    Publication date: September 12, 2024
    Inventors: DAVID A ESTELL, FRITS GOEDEGEBUUR, MARC ANTON BERNHARD KOLKMAN, RIE MEJLDAL, KATHERINE AUGUSTYN, LILIA MARIA BABE, RICHARD R. BOTT, JIAN YAO, ROOPA SANTOSH GHIRNIKAR
  • Publication number: 20240279632
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability compared to one or more reference subtilisin.
    Type: Application
    Filed: April 19, 2024
    Publication date: August 22, 2024
    Inventors: Lilia Maria Babe, Viktor Yuryevich Alekseyev, Joshua Roy Basler, H. Billur Engin, David A. Estell, Roopa Santosh Ghirnikar, Frits Goedegebuur, Thijs Kaper, Mulder Harm, Sina Pricelius, Sander Van Stigt Thans, Gudrun Vogtentanz
  • Patent number: 12043853
    Abstract: The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus sp. In some more particularly preferred embodiments, the neutral metalloprotease is obtained from B. amyloliquefaciens. In still further preferred embodiments, the neutral metalloprotease is a variant of the B. amyloliquefaciens neutral metalloprotease. In yet additional embodiments, the neutral metalloprotease is a homolog of the the B. amyloliquefaciens neutral metalloprotease. The present invention finds particular use in applications including, but not limited to cleaning, bleaching and disinfecting.
    Type: Grant
    Filed: July 15, 2021
    Date of Patent: July 23, 2024
    Assignee: DANISCO US INC.
    Inventors: Andrew Shaw, David A Estell, Eugene S Sadlowski, Hiroshi Oh, Louise Wallace, Ronaldus Wilhelmus Joannes Hommes, Sang-Kyu Lee
  • Publication number: 20240191220
    Abstract: The present invention provides serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants.
    Type: Application
    Filed: October 9, 2023
    Publication date: June 13, 2024
    Inventors: Viktor Yuryevich Alekseyev, Neelam S. Amin, Luis G. Cascao-Pereira, Katherine D. Collier, David A. Estell, James T. Kellis, JR., Ayrookaran J. Poulose, Philiip F. Souter, Glenn S. Ward, Katherine Augustyn, Jian Yao
  • Publication number: 20240182880
    Abstract: Disclosed herein is one or more subtilisin variants, nucleic acids encoding same, and compositions and methods related to the production and uses thereof, including one or more subtilisin variants that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Application
    Filed: January 5, 2024
    Publication date: June 6, 2024
    Inventors: Richard R. Bott, David A. Estell, Frits Goedegebuur, Harm Mulder, Sina Pricelius
  • Patent number: 11946080
    Abstract: Disclosed herein is one or more subtilisin variants, nucleic acids encoding same, and compositions and methods related to the production and uses thereof, including one or more subtilisin variants that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Grant
    Filed: June 18, 2017
    Date of Patent: April 2, 2024
    Assignee: DANISCO US INC.
    Inventors: Richard R. Bott, David A. Estell, Frits Goedegebuur, Harm Mulder, Sina Pricelius
  • Publication number: 20240093124
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Application
    Filed: April 17, 2023
    Publication date: March 21, 2024
    Inventors: Joshua Roy Basler, Michael Stoner, James T. Kellis, Jr., Adam Garske, David Marquez, Katherine Augustyn, Priyanka Chandrasekaran, Miles Christopher Scotcher, Lilia Maria Babe, Richard R. Bott, David A. Estell, Gudrun Vogtentanz, Sina Pricelius, Jian Yao
  • Patent number: 11898177
    Abstract: Disclosed are compositions and methods relating to variant maltohexaose-forming alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: February 13, 2024
    Assignee: DANISCO US INC.
    Inventors: Luis G Cascao-Pereira, David A Estell, Marc Anton Bernhard Kolkman, Harm Mulder
  • Publication number: 20230257728
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Application
    Filed: February 9, 2023
    Publication date: August 17, 2023
    Inventors: Lilia Maria Babe, Lydia Dankmeyer, David A. Estell, Frits Goedegebuur, Thijs Kaper, Harm Mulder, Sina Pricelius
  • Publication number: 20230203191
    Abstract: Provided herein, inter alia, are engineered antibodies or antigen-binding fragments thereof that exhibit one or more improved properties relating to manufacturability, thermostability, and/or protease resistance as well as methods for making and using the same.
    Type: Application
    Filed: March 30, 2021
    Publication date: June 29, 2023
    Inventors: David A. ESTELL, Amy Deming LIU, Michael C. MILLER, Jeffrey Wayne MUNOS, Jonathan David PETERSON
  • Patent number: 11661567
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: May 30, 2023
    Assignee: Danisco US Inc.
    Inventors: David Marquez, Michael Stoner, James T. Kellis, Jr., Adam Garske, Joshua Roy Basler, Katherine Augustyn, Priyanka Chandrasekaran, Miles Christopher Scotcher, Lilia Maria Babe, Richard R. Bott, David A. Estell, Gudrun Vogtentanz, Sina Pricelius, Jian Yao
  • Publication number: 20230159937
    Abstract: Provided herein, inter alia, are fusion DNA constructs comprising improved protease recognition sequences for expressing and purifying one or more polypeptides of interest as well as methods for producing one or more polypeptides of interest in a recombinant host cell.
    Type: Application
    Filed: March 9, 2020
    Publication date: May 25, 2023
    Inventors: Jimmy CHAN, David A. ESTELL, Amy Deming LIU, Michael C. MILLER, Igor NIKOLAEV
  • Publication number: 20230049452
    Abstract: The present disclosure provides lipolytic enzyme variants having two or more modifications as compared to a parent lipolytic enzyme. Specifically, the present disclosure provides one or more lipolytic enzyme variants that has at least one improved performance when compared to one or more reference lipolytic enzymes. In addition, the present disclosure provides compositions comprising a lipolytic enzyme variant of the disclosure. The present disclosure also provides methods of cleaning using compositions comprising a lipolytic enzyme variant of the disclosure.
    Type: Application
    Filed: January 13, 2021
    Publication date: February 16, 2023
    Applicant: DANISCO US INC
    Inventors: Felipe BENDEZU OSEAS, Angel ELIZABETH GRAC D'OLIVIERA, David A. ESTELL, Brian PAUL LAMB, Wilmelys MENZEZ, Jahnavi CHANDRA PRASAD, Yixin REN
  • Publication number: 20230028935
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability compared to one or more reference subtilisin.
    Type: Application
    Filed: November 25, 2019
    Publication date: January 26, 2023
    Inventors: Lilia Maria BABE, Viktor Yuryevich ALEKSEYEV, Joshua Roy BASLER, H. Billur ENGIN, David A. ESTELL, Roopa Santosh GHIRNIKAR, Frits GOEDEGEBUUR, Thijs KAPER, Harm MULDER, Sina PRICELIUS, Nils Henning REDESTIG, Sander VAN STIGT THANS
  • Patent number: 11499146
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more Bacillus gibsonii-clade subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: November 15, 2022
    Assignee: DANISCO US INC.
    Inventors: Lilia Maria Babe, Richard R. Bott, David A. Estell, Harm Mulder, Frits Goedegebuur, Jian Yao, Sina Pricelius, Miles Scotcher
  • Patent number: 11473075
    Abstract: The present disclosure provides AprL-clade protease enzymes, including variant AprL-clade protease enzymes, nucleic acids encoding same, and compositions and methods related to the production and use thereof, including an AprL-clade variant subtilisin enzyme that has improved stability and/or soil removal compared to a parent AprL-clade subtilisin enzyme.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: October 18, 2022
    Assignee: DANISCO US INC.
    Inventors: David A. Estell, Frits Goedegebuur, Marc Anton Bernhard Kolkman, Rie Mejldal, Katherine Augustyn, Lilia Maria Babe, Richard R Bott, Jian Yao, Roopa Santosh Ghirnikar
  • Patent number: 11447762
    Abstract: The present invention provides serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: September 20, 2022
    Assignee: Danisco US Inc.
    Inventors: Viktor Yuryevich Alekseyev, Neelam S. Amin, Luis G. Cascao-Pereira, Katherine D. Collier, David A. Estell, James T. Kellis, Jr., Ayrookaran J. Poulose, Philip F. Souter, Glenn S. Ward, Katherine Augustyn, Jian Yao