Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A new and distinct Neoregelia cultivar named ‘VD001’ is disclosed, characterized by very bright pink foliage margins and significant contrasting foliage color which is maintained under a variety of conditions. The new variety is a Neoregelia, suitable for ornamental plant purposes.

Abstract: A system comprising: a first user terminal comprising a television receiver for receiving a selected television channel, the television channel being selected by a first user activation and comprising a main video stream, and the first terminal further comprising a first controller and an output for outputting the main video stream of the selected television channel to a first screen; and a second user terminal comprising a second screen, a wireless transceiver operable to establish a wireless connection with the first terminal, and a second controller configured to communicate with the first controller via the wireless connection; wherein the television receiver of the first terminal is arranged to receive metadata relating to interactive content associated with the main video stream, and the first controller is operable to forward at least a portion of the metadata to the second terminal via said wireless connection; and the second controller is configured to process said portion of metadata and to output t

Abstract: An absorbent garment includes an extensible backsheet having opposite side regions, a liquid permeable topsheet having opposite side portions, and a retention portion having opposite side edges and an inner surface defining an area. The retention portion is disposed between the topsheet and the backsheet with the inner surface facing the topsheet and with the opposite side portions of the backsheet and the topsheet extending beyond the side edges of the retention portion. The opposite side portions of the topsheet are attached to the opposite side portions of the backsheet on opposite sides of the retention portion. Less than 30% of the area of the inner surface of the retention portion is attached to the topsheet. A method for absorbing bodily exudates with an absorbent garment is also provided.

Abstract: Disposable adult-incontinence product designs tailored to the differing anatomical features of a man's body and a woman's body are disclosed. The designs take into account differing ways in which men and women age and typically distribute weight. For example, a disposable, adult-incontinence article adapted to be worn by women may employ different leg-opening shapes, absorbent placement, ornamental features, and/or other characteristics compared to a corresponding article adapted to be worn by men. Also disclosed are ways of packaging and marketing said products to help create public awareness of the disclosed arrays of gender-specific, disposable, adult-incontinence articles, as well as individual, gender-specific, disposable, adult-incontinence articles.

Abstract: A technique for incorporating odor control agent particles into an absorbent article is provided. More specifically, the odor control particles are “homogenously” distributed (e.g., in a substantially uniform manner) within an airformed fiber matrix of an absorbent core of an absorbent article. An absorbent core containing such a homogeneously distributed odor control particles may possess a greater surface area for contacting malodorous compounds, thereby increasing the likelihood of odor reduction.

Abstract: The present invention provides a translucent absorbent composite having a substrate with a light transmittance of at least about 60% and an absorbent material applied to the substrate. The absorbent layer contains an absorbent prepared from a water soluble ionic polymer having about 15 to about 99.9% by mass monoethylenically unsaturated polymer units having at least one functional group and about 0.1 to about 20% by mass ester units selected from the group consisting of acrylate and methacrylate ester units having an alkoxysilane functionality, wherein the absorbent composite has a light transmittance of at least 45%. Also provided are absorbent articles containing the absorbent composite.

Abstract: A method of assembling an expandable absorbent garment includes providing an absorbent composite having a length, opposite ends and opposite side regions. The absorbent composite includes a backsheet, a topsheet and a retention portion disposed between the backsheet and topsheet. The backsheet includes at least one fold formed along at least one of the opposite side regions, wherein the absorbent composite is laterally expandable at least at the opposite ends thereof. The at least one fold of the backsheet is unfoldable along at least the opposite ends of the absorbent composite.

Abstract: An absorbent structure has a macro absorbent structure with a plurality of aggregate clusters intermixed therein. The aggregate clusters have a periphery, an interior, and thermoplastic binder fibers. The thermoplastic binder fibers have thermoplastic binder fiber ends. The thermoplastic binder fiber ends are located at the periphery of the aggregate clusters. The interior of the aggregate clusters are substantially free of thermoplastic binder fiber ends. The macro absorbent structure and the aggregate clusters may also include thermoplastic binder fibers, staple fibers, superabsorbent particles and the like. A method of making absorbent structures includes a first absorbent structure, dividing the first absorbent structure to create aggregate clusters, providing a stream of the aggregate clusters, providing polymeric fibers, merging the aggregate cluster stream and polymeric fiber stream into a single product stream, and making a second absorbent structure.

Abstract: An absorbent core for use in an absorbent article, the absorbent article and a method of forming the absorbent core and article are disclosed. The absorbent core includes at least three absorbent layers. The first absorbent layer is formed from a stabilized material containing a superabsorbent and has a predetermined basis weight. The two remaining absorbent layers are positioned below the first absorbent layer. Each of the two remaining absorbent layers is formed from a stabilized material containing a superabsorbent and each has a basis weight which is at least equal to the basis weight of the first absorbent layer. The absorbent article includes a liquid permeable bodyside liner and a liquid-impermeable baffle enclosing the above described absorbent core. The method describes forming the absorbent layers into an absorbent core and using the absorbent core to form an absorbent article.

Abstract: An absorbent system includes a packaging component and an absorbent article that is removably disposed in the packaging component. The absorbent article includes at least first and second portions, each defining a body side surface. The absorbent article is independently movable from a folded condition, wherein the body side surfaces of the first and second portions face each other in a substantially parallel relationship under an applied pressure applied to the first and second portions, to an unfolded condition, wherein no pressure is applied to the first and second portions. The body-side surfaces of the first and second portions form at least one angle greater than 90° in the unfolded condition when the absorbent article is positioned in the folded condition under 2800 psi of applied pressure for about 5 seconds and then is released to the unfolded condition for about 20 seconds. In yet another aspect, the absorbent article further includes a third portion having a body-side surface.

Abstract: An absorbent core for use in an absorbent article such as a diaper, training pant, feminine hygiene product, or an incontinence product includes a stabilized first absorbent layer and a second absorbent layer that contains a superabsorbent and absorbent fibers treated with a non-fugitive densification agent.

Abstract: An absorbent article, such as a thin incontinence pad or pantyliner, is disclosed which has an absorbent core formed from multiple layers of blended material for providing protection against involuntary urine loss. A method of forming the absorbent article is also disclosed. The absorbent article includes a liquid permeable bodyside liner, a liquid-impermeable baffle, and first and second absorbents positioned between the liner and the baffle. The first absorbent is a stabilized material containing a superabsorbent and has a predetermined basis weight. The second absorbent is also a stabilized material containing a superabsorbent. The second absorbent is positioned below the first absorbent and has a basis weight that is at least equal to the basis weight of the first absorbent.

Abstract: An absorbent core for use in an absorbent article such as a diaper, training pant, feminine hygiene product, or an incontinence product includes a three dimensionally patterned stabilized first absorbent layer and a second absorbent layer adjacent the first layer. An upper surface of the first three dimensionally patterned stabilized absorbent layer has a three-dimensional topography relative to the longitudinal and lateral axes and defines a plurality of peaks and valleys of the upper surface relative to the z-direction. A lower surface of the first three dimensionally patterned stabilized absorbent layer has a three-dimensional topography relative to the longitudinal and lateral axes and defines a plurality of the peaks and valleys of the lower surface relative to the z-direction.

Abstract: An absorbent core for use in an absorbent article such as a diaper, training pant, feminine hygiene product, or an incontinence product includes a stabilized first absorbent layer and a second absorbent layer that contains a superabsorbent and absorbent fibers treated with a non-fugitive densification agent.

Abstract: An absorbent garment includes an extensible backsheet having opposite side regions, a liquid permeable topsheet having opposite side portions, and a retention portion having opposite side edges and an inner surface defining an area. The retention portion is disposed between the topsheet and the backsheet with the inner surface facing the topsheet and with the opposite side portions of the backsheet and the topsheet extending beyond the side edges of the retention portion. The opposite side portions of the topsheet are attached to the opposite side portions of the backsheet on opposite sides of the retention portion. Less than 30% of the area of the inner surface of the retention portion is attached to the topsheet. A method for absorbing bodily exudates with an absorbent garment is also provided.

Abstract: An absorbent garment comprising a longitudinally extending and laterally expandable absorbent composite having opposite ends and opposite side regions. The absorbent composite comprises a backsheet, a topsheet and a retention portion disposed between the backsheet and the topsheet. In one preferred embodiment, the backsheet and retention portion each comprise at least one fold formed along at least one of the opposite side regions, with the folds being interfolded. A pair of front body panels are attached to the opposite side regions of the absorbent composite adjacent one of the opposite ends of said absorbent composite and a pair of rear body panels are attached to the opposite side regions adjacent the other of the opposite ends of the absorbent composite. In a preferred embodiment, the front and rear body panels are joined to form a pair of side body panels. A method for using the absorbent garment also is provided, together with a method for assembling the absorbent garment.

Abstract: A method of assembling an expandable absorbent garment includes providing an absorbent composite having a length, opposite ends and opposite side regions. The absorbent composite includes a backsheet, a topsheet and a retention portion disposed between the backsheet and topsheet. The backsheet includes at least one fold formed along at least one of the opposite side regions, wherein the absorbent composite is laterally expandable at least at the opposite ends thereof. The at least one fold of the backsheet is unfoldable along at least the opposite ends of the absorbent composite.

Abstract: An absorbent garment includes an extensible backsheet, a liquid permeable topsheet, a retention portion, and an outer surface. The retention portion is between the topsheet and the backsheet with the outer surface facing the backsheet and with the opposite side portions of the backsheet and the topsheet extending beyond the side edges of the retention portion. The opposite side portions of the topsheet are attached to the opposite side portions of the backsheet on opposite sides of the retention portion. Less than 30% of the area of the outer surface of the retention portion is attached to the backsheet. In one embodiment, the retention portion is freefloating between the backsheet and topsheet. In one embodiment, the topsheet is extensible. In another embodiment, less than 30% of an inner surface of the retention portion is attached to the topsheet. In another embodiment, the retention portion includes at least one fold.

Abstract: A new and distinct Neoregelia cultivar named ‘VD001’ is disclosed, characterized by very bright pink foliage margins and significant contrasting foliage color which is maintained under a variety of conditions. The new variety is a Neoregelia, suitable for ornamental plant purposes.