Patents by Inventor David A. Ferrick

David A. Ferrick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD AND SYSTEM FOR DETERMINING INTEGRATED METABOLIC BASELINE AND POTENTIAL OF LIVING CELLS
    Publication number: 20240302355
    Abstract: The current technology is related to methods for rapidly determining the metabolic baseline and potential of living cells. Embodiments relate to measuring the activity of each of the two major energy-generating pathways within the cell: mitochondrial respiration and glycolysis, first under baseline conditions, and again after applying a stress to the cells to demand increased energy supply. In some embodiments the stress may be applied by exposing the cells to a combination of two chemical compounds: a mitochondrial uncoupler and an ATP synthase inhibitor. In one embodiment, the metabolic energy generating activity of the mitochondrial respiration pathway is determined by measuring the rate of oxygen consumption by the living cells, and the metabolic energy generating activity of the glycolysis pathway is determined from a measurement of extracellular acidification caused by secretion of protons from the cell.
    Type: Application
    Filed: March 19, 2024
    Publication date: September 12, 2024
    Inventors: David A. Ferrick, Brian Dranka
  • Method and system for determining integrated metabolic baseline and potential of living cells
    Patent number: 11940442
    Abstract: The current technology is related to methods for rapidly determining the metabolic baseline and potential of living cells. Embodiments relate to measuring the activity of each of the two major energy-generating pathways within the cell: mitochondrial respiration and glycolysis, first under baseline conditions, and again after applying a stress to the cells to demand increased energy supply. In some embodiments the stress may be applied by exposing the cells to a combination of two chemical compounds: a mitochondrial uncoupler and an ATP synthase inhibitor. In one embodiment, the metabolic energy generating activity of the mitochondrial respiration pathway is determined by measuring the rate of oxygen consumption by the living cells, and the metabolic energy generating activity of the glycolysis pathway is determined from a measurement of extracellular acidification caused by secretion of protons from the cell.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: March 26, 2024
    Assignee: Agilent Technologies, Inc.
    Inventors: David A. Ferrick, Brian Dranka
  • METHOD AND SYSTEM FOR DETERMINING INTEGRATED METABOLIC BASELINE AND POTENTIAL OF LIVING CELLS
    Publication number: 20200333327
    Abstract: The current technology is related to methods for rapidly determining the metabolic baseline and potential of living cells. Embodiments relate to measuring the activity of each of the two major energy-generating pathways within the cell: mitochondrial respiration and glycolysis, first under baseline conditions, and again after applying a stress to the cells to demand increased energy supply. In some embodiments the stress may be applied by exposing the cells to a combination of two chemical compounds: a mitochondrial uncoupler and an ATP synthase inhibitor. In one embodiment, the metabolic energy generating activity of the mitochondrial respiration pathway is determined by measuring the rate of oxygen consumption by the living cells, and the metabolic energy generating activity of the glycolysis pathway is determined from a measurement of extracellular acidification caused by secretion of protons from the cell.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 22, 2020
    Inventors: David A. Ferrick, Brian Dranka
  • METHOD AND SYSTEM FOR DETERMINING INTEGRATED METABOLIC BASELINE AND POTENTIAL OF LIVING CELLS
    Publication number: 20160281049
    Abstract: The current technology is related to methods for rapidly determining the metabolic baseline and potential of living cells. Embodiments relate to measuring the activity of each of the two major energy-generating pathways within the cell: mitochondrial respiration and glycolysis, first under baseline conditions, and again after applying a stress to the cells to demand increased energy supply. In some embodiments the stress may be applied by exposing the cells to a combination of two chemical compounds: a mitochondrial uncoupler and an ATP synthase inhibitor. In one embodiment, the metabolic energy generating activity of the mitochondrial respiration pathway is determined by measuring the rate of oxygen consumption by the living cells, and the metabolic energy generating activity of the glycolysis pathway is determined from a measurement of extracellular acidification caused by secretion of protons from the cell.
    Type: Application
    Filed: March 28, 2016
    Publication date: September 29, 2016
    Inventors: David A. Ferrick, Brian Dranka
  • Methods and compositions for screening for modulators of IgE synthesis, secretion and switch rearrangement
    Patent number: 7153665
    Abstract: The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: December 26, 2006
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: David A. Ferrick, Susan E. Swift, Randall Armstrong, Bryan Fox
  • Methods and compositions for screening for modulators of IgE synthesis, secretion and switch rearrangement
    Patent number: 7041467
    Abstract: The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: May 9, 2006
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: David A. Ferrick, Susan E. Swift, Randall Armstrong, Bryan Fox
  • Methods and compositions for screening for modulations of IgE synthesis, secretion and switch rearrangement
    Patent number: 7001733
    Abstract: The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: February 21, 2006
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: David A. Ferrick, Susan E. Swift, Randall Armstrong, Bryan Fox
  • Vector for screening for modulators of IgE synthesis, secretion and switch rearrangement
    Patent number: 6953688
    Abstract: The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: October 11, 2005
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: David A. Ferrick, Susan E. Swift, Randall Armstrong, Bryan Fox
  • Methods and compositions for screening for modulators of IgE synthesis, secretion and switch rearrangement
    Publication number: 20040214155
    Abstract: The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.
    Type: Application
    Filed: September 25, 2001
    Publication date: October 28, 2004
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: David A. Ferrick, Susan E. Swift, Randall Armstrong, Bryan Fox
  • Methods of screening for bioactive agents using cells transformed with self-inactivating viral vectors
    Publication number: 20040002056
    Abstract: The invention relates to cells transformed with self-inactivating retroviral vectors and their use in methods of screening for candidate bioactive agents that produce an altered phenotype in the cells.
    Type: Application
    Filed: May 15, 2002
    Publication date: January 1, 2004
    Inventors: James B. Lorens, David A. Ferrick
  • Retroviral vectors with separation sequences
    Publication number: 20030099932
    Abstract: The invention relates to retroviral vectors comprising fusion nucleic acids useful for expressing a plurality of separate proteins products encoded by genes of interest. The invention further relates to use of the compositions in methods for screening for candidate agents producing an altered phenotype in cells.
    Type: Application
    Filed: May 3, 2002
    Publication date: May 29, 2003
    Inventors: James B. Lorens, David A. Ferrick
  • Methods and compositions for screening for modulators of IgE synthesis, secretion and switch rearrangement
    Publication number: 20020168649
    Abstract: The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.
    Type: Application
    Filed: September 27, 2001
    Publication date: November 14, 2002
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: David A. Ferrick, Susan E. Swift, Randall Armstrong, Bryan Fox
  • Methods and compositions for screening for modulators of IgE synthesis, secretion and switch rearrangement
    Publication number: 20020123076
    Abstract: The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.
    Type: Application
    Filed: September 25, 2001
    Publication date: September 5, 2002
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: David A. Ferrick, Susan E. Swift, Randall Armstrong, Bryan Fox