Patents by Inventor David A. Flockhart

David A. Flockhart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS TO EVALUATE CYTOCHROME P450 2C19 ISOENZYME ACTIVITY USING A BREATH TEST
    Publication number: 20110111510
    Abstract: The present invention relates, generally to a method of determining and assessing cytochrome P450 2C19-related (CYP2C19) metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhaled by the subject upon intravenous or oral administration of a 13C-labeled CYP2C19 substrate compound. The present invention is useful as anon-invasive, in vivo assay for evaluating CYP2C19 enzyme activity in a subject using the metabolite 13CO2 in expired breath, to phenotype individual subjects and to determine the selection, optimal dosage and timing of drug administration.
    Type: Application
    Filed: November 9, 2010
    Publication date: May 12, 2011
    Inventors: David A. Flockhart, Zeruesenay Desta, Anil S. Modak, Yasuhisa Kurogi
  • Methods to evaluate cytochrome P450 2C19 isoenzyme activity using a breath test
    Patent number: 7833744
    Abstract: The present invention relates, generally to a method of determining and assessing cytochrome P450 2C19-related (CYP2Cl9) metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhaled by the subject upon intravenous or oral administration of a 13C-labeled CYP2C19 substrate compound. The present invention is useful as a non-invasive, in vivo assay for evaluating CYP2C19 enzyme activity in a subject using the metabolite 13CO2 in expired breath, to phenotype individual subjects and to determine the selection, optimal dosage and timing of drug administration.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: November 16, 2010
    Assignee: Cambridge Isotope Laboratories, Inc.
    Inventors: David A. Flockhart, Zeruesenay Desta, Anil S. Modak, Yasuhisa Kurogi