Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.

Abstract: An atherectomy system includes a handle having a handle housing, with a drive member extending through the handle housing and operably coupled to an atherectomy burr. A drive mechanism is disposed within the handle housing and is adapted to rotatably engage the drive member. The drive mechanism may include an electric drive motor, a drive gear that is rotatably engaged with the electric drive motor and a driven gear that is coupled with the drive member and is engaged with the drive gear such that rotation of the driven gear causes rotation of the drive member. The drive mechanism may be configured to enable a rotation speed of the atherectomy burr of up to at least about 200,000 revolutions per minute (rpm).

Abstract: A system and methods of an active protection system (or “APS”) for a platform. The APS has a threat cueing sensor provided at a first position on the platform where the threat cueing sensor detects a threat launched from a threat guidance system at a distance away from the platform. The APS also has a logic system operably connected to the threat cueing sensor where the logic system is adapted to determine an estimated location of the threat guidance system via a distance away from the platform. The APS also has a laser source operably connected to the logic system where the laser source emits a countermeasure beam directed at the estimated location of the threat guidance system to deter the threat away from the platform.

Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: A phosphate-free automatic dishwashing cleaning composition comprising i) a protease wherein the protease is a variant having at least 60% identity with the amino acid sequence of SEQ ID NO:1 and comprising at least one amino acid substitution (using the SEQ ID NO: 1 numbering) selected from the group consisting of X54T; X126A, D, G, V, E, K, I; X127E, S, T, A, P, G, C; and X128E, C, T, D, P, G, L, Y, N; and ii) from 10 to 50% by weight of the composition of a complexing agent system comprising from 0 to less than 30% by weight of the composition of citric acid.

Abstract: A smart sensor early warning notification system. Certain aspects of the present disclosure provide for a smart sensor early warning notification system comprising a smart sensor coupled to a door and configured to detect one or more unauthorized access events, including sawing, blunt force and other atypical vibrations to the door. A smart sensor may be communicably engaged with a local alarm to communicate sensor data received at the smart sensor. The local alarm may be configured to process the sensor data received from the smart sensor and trigger an alarm event and/or notification or pre-event detection alert in response to the sensor data. A door controller may be configured to send different pulses or messages to indicate the type of alarm event to an alarm management server and/or access control servers via public/private cloud.

Abstract: Techniques for collecting, synchronizing, and displaying various types of data relating to a road segment enable, via one or more local or remote processors, servers, transceivers, and/or sensors, (i) enhanced and contextualized analysis of vehicle events by way of synchronizing different data types, relating to a monitored road segment, collected via various different types of data sources; (ii) enhanced and contextualized analysis of filed insurance claims pertaining to a vehicle incident at a road segment; (iii) advantageous machine learning techniques for predicting a level of risk assumed for a given vehicle event or a given road segment; (iv) techniques for accounting for region-specific driver profiles when controlling autonomous vehicles; and/or (v) improved techniques for providing a GUI to display collected data in a meaningful and contextualized manner.

Abstract: An atherectomy system includes a handle and a drive motor that is adapted to rotate a drive cable extending through the handle and operably coupled to an atherectomy burr. A control system is adapted to regulate operation of the drive motor, including providing the drive motor with a high frequency pulse width modulation (PWM) drive signal in order to operate the drive motor. The control system monitors a motor performance parameter such as motor speed or motor torque, and when the motor performance parameter approaches a limit of a performance range, the control system adds a low frequency PWM signal to the high frequency PWM drive signal, thereby causing the drive motor to produce a tactile signal that signals to the user that the motor performance parameter is approaching the limit of the performance range.

Abstract: Disclosed are devices and methods for optimizing a protective helmet or other item of protective clothing with one or more enhanced principal impact zones and/or impact elements that incorporate protective features that can be particularized to a specific player-position and/or the individual behavior of a specific player or wearer.

Abstract: A hybrid electric vehicle charging station (EVCS) is provided. The EVCS includes a charging chassis that is configured to support a charging circuitry for providing a charge current to an electric vehicle and a multi-conductor cable that is attached to the charging chassis and that receives the charging current from the charging circuitry and that transmits the charging current to the electric vehicle. The EVCS further includes a user interface that is attached to the charging chassis and that is configured to provide digital content to a vehicle operator during a charging event of the electric vehicle. The charging chassis includes multiple user interface attachment structures that are each configured to support the user interface.

Abstract: Methods and devices for evaluating viability and/or degree of contamination of cells cultured in a reactor, which includes providing luminescent dye in the reactor whose luminescence anisotropy is influenced by the viability or the degree of contamination of the cells, exciting the luminescent dye to luminesce by irradiating polarized light into the medium. polarizing light emitted by the luminescent dye that leaves the medium, and detecting the polarized emitted light with a light sensor, where the polarized emitted light is detected as at least two luminescence values in at least two different polarization angles, and determining at least one anisotropy value from the at least two luminescence values by means of mathematical methods, which correlates with the viability or the degree of contamination of the cells.

Abstract: A fluid sensor cartridge that can be used to monitor composition of constituent materials or characteristics of a sample fluid or a patient's blood. The fluid sensor cartridge can be connected in-line with a medical device during a medical treatment. The fluid sensor cartridge can utilize one or more valves, one or more channels, and one or more reservoirs to enable sampling, sensing, and calibrating of a sample fluid or a patient's blood in one container with minimal amounts of sample/blood and calibration fluid.

Abstract: To reduce the total amount of linear sequence (DNA, RNA or other medium) required to encode a set of genetic elements, the present disclosure describes a computational method for compressing genetic information by finding one or more sequences that each mutually encode multiple genetic elements in the same stretch of sequence (a “co-encoding”). The computational method encodes each of the genetic elements in respective directed acyclic graphs (DAGs) or finite automatons (FAs), then encodes overlapping sequences between the DAGs or FAs in a second DAG or FA. Additional DAGs or FAs may be encoded for overlapping sequences that result from shifting the reading frame of the genetic elements relative to one another and switching the orientation of the elements.

Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: Techniques for collecting, synchronizing, and displaying various types of data relating to a road segment enable, via one or more local or remote processors, servers, transceivers, and/or sensors, (i) enhanced and contextualized analysis of vehicle events by way of synchronizing different data types, relating to a monitored road segment, collected via various different types of data sources; (ii) enhanced and contextualized analysis of filed insurance claims pertaining to a vehicle incident at a road segment; (iii) advantageous machine learning techniques for predicting a level of risk assumed for a given vehicle event or a given road segment; (iv) techniques for accounting for region-specific driver profiles when controlling autonomous vehicles; and/or (v) improved techniques for providing a GUI to display collected data in a meaningful and contextualized manner.

Abstract: Techniques for collecting, synchronizing, and displaying various types of data relating to a road segment enable, via one or more local or remote processors, servers, transceivers, and/or sensors, (i) enhanced and contextualized analysis of vehicle events by way of synchronizing different data types, relating to a monitored road segment, collected via various different types of data sources; (ii) enhanced and contextualized analysis of filed insurance claims pertaining to a vehicle incident at a road segment; (iii) advantageous machine learning techniques for predicting a level of risk assumed for a given vehicle event or a given road segment; (iv) techniques for accounting for region-specific driver profiles when controlling autonomous vehicles; and/or (v) improved techniques for providing a GUI to display collected data in a meaningful and contextualized manner.

Abstract: The present disclosure relates to configuring and operating Internet of things (IoT) elements connected by a network. A computing device receives an interface component corresponding to an IoT element. The computing device retrieves a description of the interface component at least describing a set of restrictions of an operation of the IoT element. The computing device deploys the interface component in the computing device to at least translate events and commands specific to the IoT element to common events and commands for processing in the computing device. The computing device sends at least a subset of the description of the interface component to a user device to cause the user device to generate a user interface for configuring the operation of the IoT element.

Abstract: A load sensor includes a compressible body positionable between two surfaces. The compressible body has a plurality of aligned layers including first and second outer shims with a middle shim positioned therebetween and with a resilient material interposed between each adjacent shim. The second outer shim has a gap that exposes an unsupported area of the middle shim. A strain gauge is coupled to the middle shim in the unsupported area. When the compressible body is uncompressed, the resilient material interposed between the first outer shim and the middle shim has a substantially uniform thickness. When the compressible body is compressed between the two surfaces, the resilient material aligned with the unsupported area and interposed between the first outer shim and the middle shim has a nonuniform thickness such that the middle shim deflects away from the first outer shim in the unsupported area, thereby deforming the strain gauge.

Abstract: A sensor module is disclosed. The sensor module can include a housing body that is disposed about a cavity that is sized and shaped to receive a container in which a substance is disposed in an operational configuration of the sensor module. The sensor module can include a first electrode that is coupled to or formed with the housing body. The first electrode is disposed at a first peripheral position on the housing body. The sensor module can include a second electrode that is coupled to or formed with the housing body. The second electrode is disposed at a second peripheral position on the housing body that is opposite the first peripheral position. The cavity is disposed between the first and second electrodes in the operational configuration of the housing body.

Abstract: Techniques for collecting, synchronizing, and displaying various types of data relating to a road segment enable, via one or more local or remote processors, servers, transceivers, and/or sensors, (i) enhanced and contextualized analysis of vehicle events by way of synchronizing different data types, relating to a monitored road segment, collected via various different types of data sources; (ii) enhanced and contextualized analysis of filed insurance claims pertaining to a vehicle incident at a road segment; (iii) advantageous machine learning techniques for predicting a level of risk assumed for a given vehicle event or a given road segment; (iv) techniques for accounting for region-specific driver profiles when controlling autonomous vehicles; and/or (v) improved techniques for providing a GUI to display collected data in a meaningful and contextualized manner.