Patents by Inventor David A. Gewirtz

David A. Gewirtz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination of radiation and vitamin D3 analogs for the treatment of cancer
    Publication number: 20020137731
    Abstract: The present invention is drawn to the use of a vitamin D3 analogs in combination with radiation therapy for the treatment of hyperproliferative diseases, including cancer. Such combination therapies may be combined with additional therapies such as chemotherapy, immunotherapy, gene therapy or surgery.
    Type: Application
    Filed: May 30, 2001
    Publication date: September 26, 2002
    Inventor: David A. Gewirtz
  • Pharmaco-gene delivery in human breast cancer cells
    Patent number: 5962667
    Abstract: Estradiol facilitates non-viral gene delivery to breast tumor cells. The effect is dose dependent, and is independent of the gene construct, temperature, and tumor cell line. Thus, compositions and treatment regimens that use estradiol, or other estrogen pharmacologic agents, in combination with genes of interest can be used to provide targeted delivery and expression of genetic products in target cells and tissues of estrogen, such as breast cells. The compositions and treatment regimens have particular application to the enhanced delivery of genetic constructs useful in killing breast tumor cells and preventing tumor recurrence.
    Type: Grant
    Filed: November 3, 1997
    Date of Patent: October 5, 1999
    Assignee: Virginia Commonwealth University
    Inventors: Pramod Jain, David Gewirtz