Abstract: This invention pertains to a method of preparing mixed phase co-crystals of active agents with one or more materials that allows the modification of the active agent to a new physical/crystal form with unique properties useful for the delivery of the active agent, as well as compositions comprising the mixed phase co-crystals.

Abstract: The invention is related to the discovery that a met66val polymorphism in the gene for brain-derived neurotrophic factor (BDNF) is correlated with hippocampal function and verbal memory and risk for neuropsychiatric disorders such as schizophrenia.

Abstract: A method and system are disclosed for automatically generating embroidery designs from a scanned image. An embroidery data generating mechanism generates accurate embroidery designs. The embroidery data generating mechanism first reads an image data file, which contains bitmapping information generated from a software scanning tool, the information being related to an embroidery pattern that has been scanned. The scanned pattern is broken up into pixels, each pixel in the scanned image having a bitmap associated with the color of the pattern. Each unique color in the scanned pattern has its own unique bitmap. The embroidery generating mechanism also includes a segmentation mechanism and a chain-encoding mechanism which perform operations to enhance the quality of the bitmapped information and to separate regions of the scanned image into objects. A distance transform evaluation mechanism classifies each object as being either a thick object or a thin, predominantly regular object.

Abstract: A method and system are disclosed for automatically generating embroidery designs from a scanned image. An embroidery data generating mechanism generates accurate embroidery designs. The embroidery data generating mechanism first reads an image data file, which contains bitmapping information generated from a software scanning tool, the information being related to an embroidery pattern that has been scanned. The scanned pattern is broken up into pixels, each pixel in the scanned image having a bitmap associated with the color of the pattern. Each unique color in the scanned pattern has its own unique bitmap. The embroidery generating mechanism also includes a segmentation mechanism and a chain-encoding mechanism which perform operations to enhance the quality of the bitmapped information and to separate regions of the scanned image into objects. A distance transform evaluation mechanism classifies each object as being either a thick object or a thin, predominantly regular object.

Abstract: A method and system are disclosed for automatically generating embroidery designs from a scanned image. An embroidery data generating mechanism generates accurate embroidery designs. The embroidery data generating mechanism first reads an image data file, which contains bitmapping information generated from a software scanning tool, the information being related to an embroidery pattern that has been scanned. The scanned pattern is broken up into pixels, each pixel in the scanned image having a bitmap associated with the color of the pattern. Each unique color in the scanned pattern has its own unique bitmap. The embroidery generating mechanism also includes a segmentation mechanism and a chain-encoding mechanism which perform operations to enhance the quality of the bitmapped information and to separate regions of the scanned image into objects. A distance transform evaluation mechanism classifies each object as being either a thick object or a thin, predominantly regular object.

Abstract: A method and system are disclosed for automatically generating embroidery designs from a scanned image. An embroidery data generating mechanism generates accurate embroidery designs. The embroidery data generating mechanism first reads an image data file, which contains bitmapping information generated from a software scanning tool, the information being related to an embroidery pattern that has been scanned. The scanned pattern is broken up into pixels, each pixel in the scanned image having a bitmap associated with the color of the pattern. Each unique color in the scanned pattern has its own unique bitmap. The embroidery generating mechanism also includes a segmentation mechanism and a chain-encoding mechanism which perform operations to enhance the quality of the bitmapped information and to separate regions of the scanned image into objects. A distance transform evaluation mechanism classifies each object as being either a thick object or a thin, predominantly regular object.

Abstract: A method and system are disclosed for automatically generating embroidery designs from a scanned image. An embroidery data generating mechanism generates accurate embroidery designs. The embroidery data generating mechanism first reads an image data file, which contains bitmapping information generated from a software scanning tool, the information being related to an embroidery pattern that has been scanned. The scanned pattern is broken up into pixels, each pixel in the scanned image having a bitmap associated with the color of the pattern. Each unique color in the scanned pattern has its own unique bitmap. The embroidery generating mechanism also includes a segmentation mechanism and a chain-encoding mechanism which perform operations to enhance the quality of the bitmapped information and to separate regions of the scanned image into objects. A distance transform evaluation mechanism classifies each object as being either a thick object or a thin, predominantly regular object.

Abstract: Apparatus and methods for generating embroidery data from image data automatically identify at least one image characteristic based on at least one of edge contour data and skeletal data. The identified at least one image characteristic includes at least one of a singularity, a discontinuity and a concavity. The methods and apparatus generate the embroidery data based on the at least one image characteristic.

Abstract: Compositions and methods based on a polymorphism in the gene encoding the &agr;6 subunit of the human GABAA neurotransmitter receptor are disclosed. This polymorphism results in the substitution of a serine residue for a proline residue ordinarily present at amino acid position 385 of the &agr;6 polypeptide sequence. Significantly, the polymorphism was associated with decreased sensitivity to ethanol and benzodiazepine drugs.

Abstract: A communication circuitry for providing effective detection of tones in a communication network. The communication circuitry comprises filtration circuitry, summation circuitry, detection circuitry, and interface circuitry. The filtration circuitry is coupled to the summation circuitry and is configured to receive a communication, process the communication to estimate an echo return in the communication, and provide the estimated echo return to the summation circuitry. The summation circuitry is coupled to the detection circuitry and configured to receive the estimated echo return from the filtration circuitry, receive a tone transmission and echo return from the interface circuitry, subtract the estimated echo return from the tone transmission to generate a substantially pure tone, and provide the substantially pure tone to the detection circuitry. The detection circuitry is configured to receive the substantially pure tone and process the substantially pure tone to perform a programmed operation.

Abstract: Sequence variations, such as polymorphisms, are detected by detecting differences between or among melting profiles of plural nucleic acids. Melting profiles are produced by observing the nucleic acids during a temperature change over a period of time. If the nucleic acids are diluted into solutions for analysis, the nucleic acid concentrations between or among the solutions can be substantially the same. The melting profiles and sequence variation can be used to identify changes in a wild-type nucleic acid sequence, such as a single-nucleotide polymorphism (SNP), a small insertion or deletion, or a small inversion.

Abstract: Compositions and methods based on a polymorphism in the gene encoding the &agr;6 subunit of the human GABAA neurotransmitter receptor are disclosed. This polymorphism results in the substitution of a serine residue for a proline residue ordinarily present at amino acid position 385 of the &agr;6 polypeptide sequence. Significantly, the polymorphism was associated with decreased sensitivity to ethanol and benzodiazepine drugs.

Abstract: The invention provides a method of detecting impaired prefrontal cognitive function in an individual by determining the individual's COMT genotype, and associating a high activity Val allele with impaired prefrontal cognitive function (and a low activity Met allele with enhanced prefrontal cognitive function).

Abstract: In a preferred embodiment, a flash card unit, including: a housing; receiving means to receive in the housing a flash card having thereon at least first and second graphics; illuminating apparatus disposed in the housing to selectively illuminate at least one of the first and second graphics; the first graphic including a problem to be solved; and the second graphic including an answer to the problem.

Abstract: In a preferred embodiment, a shaft sensor for a machine, the shaft sensor including: first and second disks, fixedly orthogonally attached to a portion of a shaft of the machine, the portion of the shaft being subject to torsion, and the first and second disks being operatively attached to the portion of the shaft at spaced apart locations along the portion of the shaft; and a sensor assembly, including first and second sensors, disposed in sensing relationship with the first and second disks to sense relative position of the first and second disks resulting from torsion of the portion of the shaft and to output a signal representative of at least one parameter related to torsion of the shaft. In another preferred embodiment, the shaft is discontinuous and the first and second disks are attached, respectively, to first and second portions of the shaft and have a resilient member disposed therebetween.

Abstract: A user interface and method are disclosed for manipulating singular regions (termed singularities) for automatic embroidery data generation. A method is already known for automatically interpreting singular regions within an image so that embroidery data can be generated to recreate those singularities in an accurate and aesthetically pleasing manner. By using the present invention a user, with minimal effort, can gain greater control over the interpretation process. At the core of this extension is a single mouse click interface that allows the next best interpretation to be chosen easily. Additionally, the user may more precisely adjust interpretations, and provisions are made that allow automatic re-application of those adjustments to similar singularities encountered later.

Abstract: A method and system are disclosed for automatically generating embroidery designs from a scanned image. An embroidery data generating mechanism generates accurate embroidery designs. The embroidery data generating mechanism first reads an image data file, which contains bitmapping information generated from a software scanning tool, the information being related to an embroidery pattern that has been scanned. The scanned pattern is broken up into pixels, each pixel in the scanned image having a bitmap associated with the color of the pattern. Each unique color in the scanned pattern has its own unique bitmap. The embroidery generating mechanism also includes a segmentation mechanism and a chain-encoding mechanism which perform operations to enhance the quality of the bitmapped information and to separate regions of the scanned image into objects. A distance transform evaluation mechanism classifies each object as being either a thick object or a thin, predominantly regular object.

Abstract: The invention described herein is an apparatus for accessing an information repository, including computer readable program code stored on computer readable media, where the computer readable program code includes code for organizing information stored in the information repository into a hierarchy. The hierarchy is a hierarchy of a number of derived containers that are generated in conformance with an information model which is a hierarchy of container definition nodes. Each of the derived containers corresponds to a different one of the container definition nodes, represents a category of information in the information repository, and has contents which can be other derived containers and/or information extracted from the information repository.

Abstract: In a preferred embodiment, a display device, including: a front panel and/or a rear panel having defined therethrough at least two apertures; and an index panel(s) disposed behind the front panel and/or the rear panel and moveable between at least first and second positions to vary what can be viewed through the at least two apertures by an observer looking at the front panel and/or the rear panel. In one aspect of the invention, the display device is a book, with the front panel and/or the rear panel being a page(s) of the book and the index wheel(s) being disposed at the front and/or the rear of the book.