Abstract: This invention relates to a therapeutic composition comprising i) at least two immune checkpoint inhibitors, ii) at least one drug selected from a cytokine a cytotoxic or cytostatic chemotherapeutic drug, and combinations thereof, and iii) a cancer vaccine prepared from tumor or cancer cells, or derivatives thereof, that have been prepared through an ex vivo treatment that creates necrotic and/or necroptotic cancer cells while minimizing destruction of cancer antigens. This invention also relates to a method of treating a tumor or a cancer in a patient comprising administering to a patient in need thereof the therapeutic composition in an amount effective to treat the tumor or cancer.

Abstract: This invention relates to a pharmaceutical composition comprising at least two immune checkpoint inhibitors, at least one cytotoxic or cytostatic chemotherapeutic drug. This invention also relates to a method of treating a tumor or a cancer in a patient comprising administering to a patient in need thereof the pharmaceutical composition in an amount effective to treat the tumor or cancer, and optionally a step of ablating at least a portion of the tumor or cancer.

Abstract: An intramedullary device, having a first longitudinal axis extending between a proximal end and a distal end thereof, is provided. The intramedullary device may include a first bore and a second bore. The first bore may include a second longitudinal axis and may extend through the intramedullary device between a first opening and a second opening. The second longitudinal axis may define a first angle (?1) with the first longitudinal axis. The second bore may include a third longitudinal axis and may extend through the intramedullary device between the first opening and a third opening. The third longitudinal axis may define a second angle (?2) with the first longitudinal axis.

Abstract: An intramedullary device, having a first longitudinal axis extending between a proximal end and a distal end thereof, is provided. The intramedullary device may include a first bore and a second bore. The first bore may include a second longitudinal axis and may extend through the intramedullary device between a first opening and a second opening. The second longitudinal axis may define a first angle (?1) with the first longitudinal axis. The second bore may include a third longitudinal axis and may extend through the intramedullary device between the first opening and a third opening. The third longitudinal axis may define a second angle (?2) with the first longitudinal axis.

Abstract: An air freshener system includes a roll paper assembly and an air freshener assembly coupled with the roll paper assembly. The air freshener assembly includes an integrated air freshener element in the form of a single, continuous gel component.

Abstract: An assembly for evaporation and dispensing of a volatile liquid. The assembly includes an emanator element and a body member. The emanator element has an open structure with a high surface area and is made of a material that is able to absorb and evaporate volatile liquids. The body member includes a tubular portion which has an interior wall for receiving the emanator element, the latter possibly being therein spaced from the interior wall to allow air flow therethrough. A reservoir of volatile liquid and a wicking member are also provided with the wicking element extending from the emanator element into the volatile liquid. The assembly is further associated with an air moving component for directing air flow though the tubular portion and around and through the open structure of the emanator element, thus carrying evaporated liquid volatiles out of the body member.

Abstract: An air freshener system includes a roll paper assembly and an air freshener assembly coupled with the roll paper assembly. The air freshener assembly includes an integrated air freshener element in the form of a single, continuous gel component.

Abstract: An assembly for evaporation and dispensing of a volatile liquid. The assembly includes an emanator element and a body member. The emanator element has an open structure with a high surface area and is made of a material that is able to absorb and evaporate volatile liquids. The body member includes a tubular portion which has an interior wall for receiving the emanator element, the latter possibly being therein spaced from the interior wall to allow air flow therethrough. A reservoir of volatile liquid and a wicking member are also provided with the wicking element extending from the emanator element into the volatile liquid. The assembly is further associated with an air moving component for directing air flow though the tubular portion and around and through the open structure of the emanator element, thus carrying evaporated liquid volatiles out of the body member.

Abstract: A device for distributing a volatile fluid into a surrounding environment. In one exemplary embodiment, the distribution device includes a dual centrifugal blower having a first blower and a second blower, both of which are driven by a common motor. Additionally, in one exemplary embodiment, substantially identical components may be used to form both the first and second blowers of the dual centrifugal blower, which reduces manufacturing costs. The dual centrifugal blower may be incorporated into air freshener devices having replaceable canisters or cartridges.

Abstract: A distribution device for distributing volatile fluids in air. In an exemplary embodiment, the distribution device includes a wick formed of a solid material which is impregnated with a volatile fluid, such as a scented liquid, a disinfectant, a fungicide, an anti-allergenic substance, an insect repellant, or an insecticide, for example. In another embodiment, the device includes a substantially hollow, tubular shaped wick which includes a portion that is exposed to the surrounding environment and a portion that is in liquid communication with a liquid reservoir containing a volatile fluid. The wick is positioned in the liquid reservoir and in a close fitting engagement with an open end of the liquid reservoir. The hollow configuration of the wick provides a greater exposed surface area to enhance the evaporation of the liquid into the surrounding environment.

Abstract: A distribution device for distributing volatile fluids in air. In an exemplary embodiment, the distribution device includes a wick formed of a solid material which is impregnated with a volatile fluid, such as a scented liquid, a disinfectant, a fungicide, an anti-allergenic substance, an insect repellant, or an insecticide, for example. In another embodiment, the device includes a substantially hollow, tubular shaped wick which includes a portion that is exposed to the surrounding environment and a portion that is in liquid communication with a liquid reservoir containing a volatile fluid. The wick is positioned in the liquid reservoir and in a close fitting engagement with an open end of the liquid reservoir. The hollow configuration of the wick provides a greater exposed surface area to enhance the evaporation of the liquid into the surrounding environment.

Abstract: A method and apparatus for calibrating the temperature/color correspondence of thermal paint. A strip of metal is heated at both ends independently to achieve a predetermined temperature differential measured by thermocouples. Heat flow from the hot end to the cooler end is constrained to the test piece by enclosing it in insulation material. A linear temperature gradient is thus achieved so providing a more accurate and flexible calibrating arrangement.