Abstract: Pharmaceutical compositions including an active ingredient and a stabilizer, as well as methods of manufacture of the compositions, and methods of their use. The composition may include the active ingredient dispersed throughout a matrix of the stabilizer. In some embodiments, the active ingredient and the stabilizer are intimately mixed in a matrix formulation. In some embodiments, the active ingredient is selected from 4 amino-3-(4-chlorophenyl)butanoic acid) (“baclofen”) and its pharmaceutically acceptable salts.

Abstract: Baclofen formulations, including formulations that minimize variability between doses, that minimize variation in patient exposure to baclofen metabolites, and are bioequivalent in regards to baclofen versus M1 metabolite ratios of baclofen tablets.

Abstract: A CVT clutch is provided. A fixed sheave of the CVT clutch is statically mounted on an end of the post. A movable sheave assembly is dynamically mounted on the post. The movable sheave includes a recess cavity that is defined by a movable sheave housing. A spider is statically mounted on the post within the recess cavity of the movable sheave assembly. At least one interchangeable ramp is positioned within the recess cavity so that at least one space is provided between the at least one interchangeable ramp and a sheave face of the movable sheave housing. An engagement member is positioned to engage an associated interchangeable ramp and the spider. A main bias member is configured to assert a bias force on the spider and cover to position each engagement member at a select location on the associated interchangeable ramp when a countering force is not present.

Abstract: A CVT clutch is provided. A fixed sheave of the CVT clutch is statically mounted on an end of the post. A movable sheave assembly is dynamically mounted on the post. The movable sheave includes a recess cavity that is defined by a movable sheave housing. A spider is statically mounted on the post within the recess cavity of the movable sheave assembly. At least one interchangeable ramp is positioned within the recess cavity so that at least one space is provided between the at least one interchangeable ramp and a sheave face of the movable sheave housing. An engagement member is positioned to engage an associated interchangeable ramp and the spider. A main bias member is configured to assert a bias force on the spider and cover to position each engagement member at a select location on the associated interchangeable ramp when a countering force is not present.

Abstract: Techniques for configuring an entity are disclosed. The techniques include generating, based on multiple sets of features inputted into a machine learning model, predictions of multiple sets of performance metrics for multiple configurations of the entity. The techniques also include calculating a change in efficiency between each configuration in the multiple configurations and the base configuration based on a first set of performance metrics for the base configuration and a second set of performance metrics generated by the machine learning model for the configuration. The techniques further include determining, based on values of the change in efficiency calculated for the multiple configurations, a second set of configuration values with a highest increase in efficiency over the base configuration. The techniques additionally include causing the second set of configuration values to be outputted in association with the entity.

Abstract: The invention is a gap accessary device for elevated roller rails disposed on a platform floor. The device includes a housing, fingers, tangs, roller support structures, rollers, a first curved truncated inclined plane, and a second curved truncated inclined plane. The device allows cargo to enter a platform without catching on the platform threshold and requires less effort to load cargo onto a platform with elevated roller rails.

Abstract: The invention is a gap accessary device for elevated roller rails disposed on a platform floor. The device includes a housing, fingers, tangs, roller support structures, rollers, a first curved truncated inclined plane, and a second curved truncated inclined plane. The device allows cargo to enter a platform without catching on the platform threshold and requires less effort to load cargo onto a platform with elevated roller rails.

Abstract: A drive clutch including a primary post, a fixed sheave, a movable sheave, an activation assembly is provided. The fixed sheave is statically coupled to the primary post. The movable sheave is slidably mounted on the primary post. The activation assembly is in operational communication with the movable sheave to move the movable sheave on the primary post away from and towards the fixed sheave based on a centrifugal force experienced by the drive clutch. The activation assembly includes a spider, at least one trunnion slidably mounted on a spider arm and a main activation biasing member. The at least one trunnion has opposable extending trunnion arms. A roller is rotationally mounted on each trunnion arm. Each roller is positioned to engage a ramp profile associated with a sheave post extending from the movable sheave. The main activation biasing member is positioned to assert a biasing force on the spider.

Abstract: A drive clutch including a primary post, a fixed sheave, a movable sheave, an activation assembly is provided. The fixed sheave is statically coupled to the primary post. The movable sheave is slidably mounted on the primary post. The activation assembly is in operational communication with the movable sheave to move the movable sheave on the primary post away from and towards the fixed sheave based on a centrifugal force experienced by the drive clutch. The activation assembly includes a spider, at least one trunnion slidably mounted on a spider arm and a main activation biasing member. The at least one trunnion has opposable extending trunnion arms. A roller is rotationally mounted on each trunnion arm. Each roller is positioned to engage a ramp profile associated with a sheave post extending from the movable sheave. The main activation biasing member is positioned to assert a biasing force on the spider.

Abstract: Methods and apparatuses for tiered customization for an application with a plurality of users. In one embodiment, an application with various options for different users has a tiered system for customization to provide cost efficiency. For example, in a tiered system for customization, multiple option values can be specified for one option at multiple tiers of user group hierarchy and resolved based on the tier hierarchy to balance the capability for deep customizability, and the efficiency of resource usage. For example, a deep customizable hosted Customer Relationship Management (CRM) application allows customization from company level to individual user level.

Abstract: Embodiments of systems, methods, and software applications, which are configured to manage marketing templates that are to be used in e-mail marketing campaigns, are described in the present disclosure. According to one embodiment, among many, a computer readable medium is configured to store instructions that are executable by a processing device. The computer readable medium includes logic adapted to enable a user to create a marketing template and logic adapted to enable the user to publish the marketing template on one or more social networks. The computer readable medium also includes logic adapted to enable the user to incorporate the marketing template into an e-mail marketing campaign. Furthermore, the computer readable medium comprises logic that is adapted to track statistics related to recipients' responses to the e-mail marketing campaign.

Abstract: Methods and apparatuses for tiered customization for an application with a plurality of users. In one embodiment, an application with various options for different users has a tiered system for customization to provide cost efficiency. For example, in a tiered system for customization, multiple option values can be specified for one option at multiple tiers of user group hierarchy and resolved based on the tier hierarchy to balance the capability for deep customizability, and the efficiency of resource usage. For example, a deep customizable hosted Customer Relationship Management (CRM) application allows customization from company level to individual user level.

Abstract: Methods and apparatuses for grouped customization for an application with a plurality of users. In one embodiment, option values for options are grouped (e.g., to represent best practices) for selection by groups of users, such as users of companies of different industries of a hosted Customer Relationship Management (CRM) application. For example, serialized best practices can be grouped for use in the tiered system to provide option values for certain users or user groups.

Abstract: Enabling a transalkylation process to handle both C10 alkylaromatics and unextracted toluene permits the following improvements to be realized. No longer extracting toluene allows a reformate-splitter column to be eliminated. The extraction unit can be moved to the overhead of a benzene column that is also closely integrated with the transalkylation unit. No longer requiring a rigorous split between C9 and C10 alkylaromatics allows a heavy aromatics column to be eliminated. Such an enabled transalkylation process requires stabilization of a transalkylation catalyst through the introduction of a metal function. These improvements result in an aromatics complex apparatus with savings on inside battery limits curve costs and an improvement on the return on investment in such a complex.

Abstract: Enabling a transalkylation process to handle both C10 alkylaromatics and unextracted toluene permits the following improvements to be realized. No longer extracting toluene allows a reformate-splitter column to be eliminated. The extraction unit can be moved to the overhead of a benzene column and integrated together with the transalkylation unit to reduce costs. No longer requiring a rigorous split between C9 and C10 alkylaromatics allows a heavy aromatics column to be eliminated. Such an enabled transalkylation process requires stabilization of a transalkylation catalyst through the introduction of a metal function. These improvements result in an aromatics complex apparatus with savings on inside battery limits curve costs and an improvement on the return on investment in such a complex.

Abstract: Enabling a transalkylation process to handle both C10 alkylaromatics and unextracted toluene permits the following improvements to be realized. No longer extracting toluene allows a reformate-splitter column to be eliminated. The extraction unit can be moved to the overhead of a benzene column. No longer requiring a rigorous split between C9 and C10 alkylaromatics allows a heavy aromatics column to be eliminated. Such an enabled transalkylation process requires stabilization of a transalkylation catalyst through the introduction of a metal function. A further enhancement to the flow scheme is accomplished through the elimination of clay treaters in favor of selective olefin saturation at the exits of a reforming unit and an isomerization unit. These improvements result in an aromatics complex with savings on inside battery limits curve costs and an improvement on the return on investment in such a complex.

Abstract: Construction and operational costs of recovering the extract or raffinate product of a simulated moving bed adsorptive separation process units are reduced by employing a dividing wall column to perform the separation. The raffinate or extract stream is passed into the column at an intermediate point on the first side of the dividing wall, with the column delivering the adsorptive separation product as a sidedraw from the opposite side of the dividing wall. A stream of co-adsorbed impurity is removed as an overhead stream and desorbent is recovered as a net bottoms stream.