Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.

Abstract: The invention relates to an umbilical for use between an offshore construction (10) and a seabed installation (20), comprising one or more of longitudinal umbilical elements, such as one or more filler element, one or more signal cable, one or more fiber optic, one or more electrical power cable, and/or one or more load carrying element like carbon fiber rod, the umbilical further comprises at least one fluid pipe (1a, 1b) arranged within the umbilical (1), the longitudinal umbilical elements (1a, 1b) and the at least one fluid pipe (1a, 1b) are either laid in a continuous helix, or alternatingly/oscillatory laid within the umbilical. The at least one fluid pipe (1a, 1b) is a mix of at least one seamless pipe (1a) and at least one seam-welded pipe (1b), the at least one seamless pipe (1a) and the at least one seam-welded pipe (1b) are spliced together at one or more predetermined locations in the longitudinal direction of the umbilical (1).

Abstract: Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.

Abstract: Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.

Abstract: Power umbilical (1) comprising a plurality of power cables (7) for electric power transmission, elongated filler elements (5), and an outer sheath (3). The elongated filler elements (5) abut against each other at abutment faces (5a), thereby forming a complete ring enclosing the power cables (7). The elongated filler elements (5) comprise cable recesses (5b) within which the power cables (7) are embedded. The power umbilical (1) further comprises one or more friction control profiles (13, 15, 116), wherein the material of the friction control profile (13, 15, 116) is softer than the material of the elongated filler elements (5). The one or more friction control profiles (13, 15) are arranged in a deformed state.

Abstract: A method of treating symptoms of a subtype of epilepsy, e.g., Dravet syndrome, in a patient diagnosed with a subtype of epilepsy, by administering to the patient an effective dose of a fenfluramine formulation in combination with a ketogenic diet over a period of time sufficient to reduce or completely eliminate seizures in the patient. Also provided are compositions and kits finding use in practicing embodiments of the methods.

Abstract: An article of manufacture for providing a quick and dry decoy retrieval device includes a decoy body shaped as a waterfowl, an anchor line having an upper end and a lower end, an anchor weight coupled to the lower end of the anchor line, the anchor weight and the lower end are below the underside surface, and a finger retrieval loop coupled to the upper end. The decoy body having an upper surface, a head, an underside surface, and a waterfowl decoy keel, and a concealment cavity located in the top surface behind the head, an anchor line channel running from an entry point within the concealment cavity to an exit point on the underside surface about the waterfowl decoy keel. The anchor line being routed through the anchor line channel. The finger retrieval loop being concealed within the concealment cavity when the upper end e is about the entry.

Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.

Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.

Abstract: Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.

Abstract: A method of treating symptoms of a subtype of epilepsy, e.g., Dravet syndrome, in a patient diagnosed with a subtype of epilepsy, by administering to the patient an effective dose of a fenfluramine formulation in combination with a ketogenic diet over a period of time sufficient to reduce or completely eliminate seizures in the patient. Also provided are compositions and kits finding use in practicing embodiments of the methods.

Abstract: A method of treating symptoms of a subtype of epilepsy, e.g., Dravet syndrome, in a patient diagnosed with a subtype of epilepsy, by administering to the patient an effective dose of a fenfluramine formulation in combination with a ketogenic diet over a period of time sufficient to reduce or completely eliminate seizures in the patient. Also provided are compositions and kits finding use in practicing embodiments of the methods.

Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.

Abstract: A method of treating symptoms of a subtype of epilepsy, e.g., Dravet syndrome, in a patient diagnosed with a subtype of epilepsy, by administering to the patient an effective dose of a fenfluramine formulation in combination with a ketogenic diet over a period of time sufficient to reduce or completely eliminate seizures in the patient. Also provided are compositions and kits finding use in practicing embodiments of the methods.

Abstract: A cart transportation assembly includes a frame including at least one upright and a top rail supported by the upright(s). The top rail includes a main body portion, an actuation rod, and at least one cart latch coupled to the actuation rod. The actuation rod is movable relative to the main body portion to transition the cart latch(es) between release and restrain positions. A platform provides structural support for the frame and includes a deck for supporting at least one cart. The cart latch(es), when in the release position, is/are adapted to allow movement of the at least one cart on the deck of the platform. The cart latch(es), when in the restrain position, is/are adapted to restrain movement of the at least one cart on the deck of the platform by pulling the at least one cart towards and against or in close proximity to the frame.

Abstract: The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion protein, P170 glycoprotein. The novel compositions of the invention comprise supramolecular antigenic constructs generally comprising a peptide sequence, covalently attached to pegylated lysine resulting in modified and enhanced peptide presentation. The unique modification methodology of the present invention is applicable to a variety of peptides and can ultimately be employed in therapeutic formulations and vaccines for diseases and disorders such as Alzheimer's disease.

Abstract: The present application discloses a pallet truck backrest assembly for handling half-size pallets. A first half-size pallet support is pivotally coupled to a backrest of the backrest assembly at a first height and a second half-size pallet support is pivotally coupled to the backrest at a second height with the second height being less than the first height. The half-size pallet supports pivot between first positions against the backrest and second positions extending over the forks of the pallet truck to accommodate half-size pallets.

Abstract: A cart transportation assembly includes a frame including at least one upright and a top rail supported by the upright(s). The top rail includes a main body portion, an actuation rod, and at least one cart latch coupled to the actuation rod. The actuation rod is movable relative to the main body portion to transition the cart latch(es) between release and restrain positions. A platform provides structural support for the frame and includes a deck for supporting at least one cart. The cart latch(es), when in the release position, is/are adapted to allow movement of the at least one cart on the deck of the platform. The cart latch(es), when in the restrain position, is/are adapted to restrain movement of the at least one cart on the deck of the platform by pulling the at least one cart towards and against or in close proximity to the frame.

Abstract: The present invention relates to method for preparing liposome-based constructs comprising a peptide, particularly an antigenic peptide, of interest modified through hydrophobic moieties reconstituted in liposomes and to the antigenic constructs obtained with said method. The invention further relates to the use of said constructs for the therapeutic and diagnostic use in the treatment of diseases and disorders, which are caused by or associated with proteopathy such as Alzheimer's Disease.

Abstract: The present application discloses a pallet truck backrest assembly for handling half-size pallets. A first half-size pallet support is pivotally coupled to a backrest of the backrest assembly at a first height and a second half-size pallet support is pivotally coupled to the backrest at a second height with the second height being less than the first height. The half-size pallet supports pivot between first positions against the backrest and second positions extending over the forks of the pallet truck to accommodate half-size pallets.